The
premise
of
this
volume
is
that
there
a
continuum
semiotic
agents
across
biology,
extending
from
the
first
individually
competent
cells
to
their
colonial
aggregations
and
then
further
becoming
functioning
tissue
ecologies,
multicellular
eukaryotic
organisms,
holobionic
species.
This
same
agency
propels
collective
human
thought
our
organizations,
including
nations
or
political
movements.
Our
contribution
explains
causal
chain
by
focusing
on
conscious
cell.
In
recent
publications,
we
have
argued
presented
empirical
evidence
for
sentience/cognition
in
all
unicellular
prokaryotes
Homo
sapiens
.
Put
simply,
life
sentience
are
coterminous.
All
living
biological
entities,
feel,
learn,
remember,
choose,
react,
communicate.
biosemiotic
agents.
Therefore,
evolutionary
development
directly
related
intelligent
suite
sentient,
problem-solving
behaviors.
perspective
has
been
codified
as
Cellular
Basis
Consciousness
(CBC),
its
particulars
chapter.
Several
critical
ramifications
derive
within
parameters
cellular
sentience.
Notably,
consciousness
exists
an
organized
whole
such
even
meaningful
experiences
at
scale
include
semantic
elements.
requires
interactive
external
membrane,
separating
internal
milieu
cell
environment.
That
perceptive
membrane
must
link
retrievable
deployable
memory
enable
learning
effective
problem-solving.
complex
receptive
apparatus
supporting
termed
senome,
representing
pivotal
architecture
connecting
interior
CBC,
aspects
coordinate
support
sentience,
architecture,
genes,
tools.
Because
any
information
about
environment
travel
media
interact
with
transit
intervening
environmental
degraded
compared
source.
inescapable
informational
ambiguity
means
measure
gauge
validity.
Consequently,
self-generated
interior.
create
own
reality.
So
do
other
CBC
asserts
creatures
conscious,
plants.
On
hand,
non-biological
cannot
be
since
they
not
living.
Creating
creating
life,
which,
date,
unable
do.
Entropy,
Journal Year:
2023,
Volume and Issue:
25(1), P. 131 - 131
Published: Jan. 9, 2023
Biological
genotypes
do
not
code
directly
for
phenotypes;
developmental
physiology
is
the
control
layer
that
separates
genomes
from
capacities
ascertained
by
selection.
A
key
aspect
cellular
competency,
since
cells
are
passive
materials
but
descendants
of
unicellular
organisms
with
complex
context-sensitive
behavioral
capabilities.
To
probe
effects
different
degrees
competency
on
evolutionary
dynamics,
we
used
an
simulation
in
context
minimal
artificial
embryogeny.
Virtual
embryos
consisted
a
single
axis
positional
information
values
provided
cells’
‘structural
genes’,
operated
upon
cycle
which
embryos’
fitness
was
proportional
to
monotonicity
axial
gradient.
Evolutionary
dynamics
were
evaluated
two
modes:
hardwired
development
(genotype
encodes
phenotype),
and
more
realistic
mode
interact
prior
evaluation
function
(“regulative”
development).
We
find
even
ability
improve
their
position
embryo
results
better
performance
search.
Crucially,
observed
increasing
masks
raw
encoded
structural
genes,
selection
favoring
improvements
its
problem-solving
over
genome.
This
suggests
existence
powerful
ratchet
mechanism:
evolution
progressively
becomes
locked
intelligence
agential
substrate,
reduced
pressure
kind
feedback
loop
increasingly
puts
effort
into
software
than
perfecting
hardware
explains
very
puzzling
divergence
genome
anatomy
species
like
planaria.
In
addition,
it
identifies
possible
driver
scaling
time,
strategies
engineering
novel
systems
silico
bioengineering.
Animal Sentience,
Journal Year:
2022,
Volume and Issue:
7(32)
Published: Jan. 1, 2022
We
are
in
basic
agreement
with
Crump
et
al.
that
animal
welfare,
particularly
regard
to
the
experience
of
pain,
is
a
topic
importance.
However,
we
come
issue
from
different
perspective,
one
which
all
species
sentient
and
can
feel
pain.
The
implications
this
theory
discussed.
Plants,
Journal Year:
2022,
Volume and Issue:
11(23), P. 3203 - 3203
Published: Nov. 23, 2022
This
review
highlights
the
relationship
between
metabolism
of
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
and
H2S-reactive
sulfur
(RSS).
These
three
metabolic
pathways,
collectively
termed
oxygen,
nitrogen,
(RONSS),
constitute
a
conglomerate
reactions
that
function
as
an
energy
dissipation
mechanism,
in
addition
to
allowing
environmental
signals
be
transduced
into
cellular
information.
information,
form
proteins
with
posttranslational
modifications
or
signaling
metabolites
derived
from
RONSS,
serves
inducer
many
processes
for
redoxtasis
adjustment
changing
conditions
which
plants
are
subjected.
Although
it
is
thought
role
chemical
was
originally
dissipation,
during
evolution
they
seem
cluster
RONSS
that,
dissipating
excess
excitation
potential
reducing
potential,
also
fulfils
essential
functions
play
vital
stress
acclimation
plants.
Signaling
occurs
by
synthesizing
biomolecules
modify
activity
transcription
factors
through
thiol
groups
enzymes.
The
result
series
adjustments
plants’
gene
expression,
biochemistry,
physiology.
Therefore,
we
present
overview
synthesis
considering
importance
implications
agronomic
management,
particularly
on
biostimulation
crops.
Many
applications
in
biomedicine
and
synthetic
bioengineering
rely
on
understanding,
mapping,
predicting,
controlling
the
complex
behavior
of
chemical
genetic
networks.
The
emerging
field
diverse
intelligence
investigates
problem-solving
capacities
unconventional
agents.
However,
few
quantitative
tools
exist
for
exploring
competencies
non-conventional
systems.
Here,
we
view
gene
regulatory
networks
(GRNs)
as
agents
navigating
a
problem
space
develop
automated
to
map
robust
goal
states
GRNs
can
reach
despite
perturbations.
Our
contributions
include:
(1)
Adapting
curiosity-driven
exploration
algorithms
from
AI
discover
range
reachable
GRNs,
(2)
Proposing
empirical
tests
inspired
by
behaviorist
approaches
assess
their
navigation
competencies.
data
shows
that
models
inferred
biological
wide
spectrum
steady
states,
exhibiting
various
physiological
network
dynamics
without
requiring
structural
changes
properties
or
connectivity.
We
also
explore
applicability
these
‘behavioral
catalogs’
comparing
evolved
across
networks,
designing
drug
interventions
biomedical
contexts
bioengineering.
These
emphasis
behavior-shaping
open
new
paths
efficiently
For
interactive
version
this
paper,
please
visit
https://developmentalsystems.org/curious-exploration-of-grn-competencies
.
The Journal of Physiology,
Journal Year:
2023,
Volume and Issue:
602(11), P. 2491 - 2501
Published: Oct. 17, 2023
Cells
evolved
some
4
billion
years
ago,
and
since
then
the
integrity
of
structural
functional
continuity
cellular
life
has
been
maintained
via
highly
conserved
ancient
processes
cell
reproduction
division.
The
plasma
membrane
as
well
all
cytoplasmic
structures
are
reproduced
inherited
uninterruptedly
by
each
two
daughter
cells
resulting
from
every
Although
our
understanding
evolutionary
emergence
very
first
is
obscured
extremely
long
timeline
that
revolutionary
event,
generally
accepted
position
de
novo
formation
not
possible;
present
products
other
prior
cells.
This
essential
biological
principle
was
discovered
Robert
Remak
effectively
coined
Omnis
Cellula
e
(every
cell)
Rudolf
Virchow:
currently
living
have
direct
connections
to
Based
on
previous
theoretical
analysis,
endowed
with
individual
sentient
cognition
guides
their
agency,
behaviour
evolution.
There
a
vital
consequence
this
new
cognitive
view
cells:
when
assemble
tissue
ecologies
organs
within
multicellular
organisms,
including
plants,
animals
humans,
these
aggregates
display
derivative
versions
aggregate
tissue-
organ-specific
sentience
consciousness.
innovative
evolution
physiology
organisms
supports
singular
principle:
organismal
based
extends
unicellular
roots.
