Recent Advances on the Production of Itaconic Acid via the Fermentation and Metabolic Engineering

Fermentation, Journal Year: 2023, Volume and Issue: 9(1), P. 71 - 71

Published: Jan. 14, 2023

Itaconic acid (ITA) is one of the top 12 platform chemicals. The global ITA market expanding due to rising demand for bio-based unsaturated polyester resin and its non-toxic qualities. Although bioconversion using microbes main approach in current industrial production ITA, ecological faces several issues to: low efficiency, difficulty employ inexpensive raw materials, high manufacturing costs. As metabolic engineering advances, microorganisms offers a novel strategy promotion bio-production. In this review, most recent developments through fermentation are compiled from variety perspectives, including identification synthesis pathway, natural producers, design construction pathway model chassis, creation, as well application, new strategies production. challenges encountered bio-production microbial cell factories discussed, some suggestions future study also proposed, which it hoped insightful views promote cost-efficient sustainable ITA.

Language: Английский

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Engineering Microorganisms to Produce Bio-Based Monomers: Progress and Challenges

Fermentation, Journal Year: 2023, Volume and Issue: 9(2), P. 137 - 137

Published: Jan. 31, 2023

Bioplastics are polymers made from sustainable bio-based feedstocks. While the potential of producing monomers in microbes has been investigated for decades, their economic feasibility is still unsatisfactory compared with petroleum-derived methods. To improve overall synthetic efficiency microbial cell factories, three main strategies were summarized this review: firstly, implementing approaches to utilization ability cheap and abundant substrates; secondly, developing methods at enzymes, pathway, cellular levels enhance production performance; thirdly, building technologies pH, osmotic, metabolites stress tolerance. Moreover, challenges of, some perspectives on, exploiting microorganisms as efficient factories also discussed.

Language: Английский

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Determining the Metabolic Processes of Metal-Tolerant Fungi Isolated from Mine Tailings for Bioleaching

Minerals, Journal Year: 2024, Volume and Issue: 14(3), P. 235 - 235

Published: Feb. 26, 2024

This study examined the metal tolerance and organic acid-producing capabilities of fungal isolates from South African tailings to assess their potential for future bioleaching applications. Four were chosen additional examination based on capacity generate acids metals. In terms Al, Zn, Ni, Cr, these four isolates—Trichoderma, Talaromyces, Penicillium_3, Penicillium_6—displayed varying degrees resistance, with Trichoderma displaying a better index. The growth rates under stress varied among isolates, highest rates. high-performance liquid chromatography results, citric acid emerged as primary produced by achieving yield in shortest timeframe. Gas chromatography–mass spectrometry results showed that cycle is one main pathways production, though other related lipid biosynthesis carbohydrate metabolism also play significant roles. Three compounds involved furfural breakdown abundant. Using KEGG, link between was established, where generates an intermediate cycle.

Language: Английский

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Fumaric acid production by Rhizopus species from acid hydrolysate of oil palm empty fruit bunches

Brazilian Journal of Microbiology, Journal Year: 2024, Volume and Issue: 55(2), P. 1179 - 1187

Published: April 26, 2024

Language: Английский

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Shortening electron transfer distance to enhance chemicals and electric energy production in Escherichia coli

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154932 - 154932

Published: Aug. 17, 2024

Language: Английский

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