Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 265 - 290
Published: Dec. 17, 2024
Synthetic
biology
and
artificial
intelligence
are
ushering
in
a
new
era
of
healthcare.
In
the
specific
context
bioengineering,
organoids,
brain-computer
interfaces,
ethical
considerations
particularly
salient.
Challenges
such
as
data
inadequacy,
unintended
bias
can
undermine
reliability
fairness
decision
making.
Additionally,
cultural
barriers
concerns
related
to
nonmaleficence,
autonomy,
justice
must
be
carefully
considered.
To
fully
realize
benefits
this
technological
synergy,
multidisciplinary
approach
is
necessary,
involving
scientists,
engineers,
ethicists,
policymakers.
Transparent
accountable
AI
systems
essential
mitigate
biases,
protect
privacy,
avoid
consequences.
By
proactively
addressing
developing
robust
regulatory
frameworks,
we
harness
power
these
technologies
for
betterment
humanity.
The Innovation,
Journal Year:
2024,
Volume and Issue:
5(5), P. 100658 - 100658
Published: June 18, 2024
Disagreements
about
language
use
are
common
both
between
and
within
fields.
Where
interests
require
multidisciplinary
collaboration
or
the
field
of
research
has
potential
to
impact
society
at
large,
it
becomes
critical
minimize
these
disagreements
where
possible.
The
development
diverse
intelligent
systems,
regardless
substrate
(e.g.,
silicon
vs.
biology),
is
a
case
conditions
met.
Significant
advancements
have
occurred
in
technology
progressing
toward
intelligence
systems.
Whether
progress
based,
such
as
large
models,
through
synthetic
biology
methods,
organoids,
clear
need
for
community-based
approach
seeking
consensus
on
nomenclature
now
vital.
Here,
we
welcome
from
wider
scientific
community,
proposing
pathway
forward
achieving
this
intention,
highlighting
key
terms
fields
relevance,
suggesting
consensus-making
methods
be
applied.
Oxford Open Neuroscience,
Journal Year:
2024,
Volume and Issue:
3
Published: Jan. 1, 2024
Abstract
Human
brain
organoids
equipped
with
complex
cytoarchitecture
and
closed-loop
feedback
from
virtual
environments
could
provide
insights
into
neural
mechanisms
underlying
cognition.
Yet
certain
cognitive
capacities
might
also
merit
moral
consideration.
A
precautionary
approach
has
been
proposed
to
address
these
ethical
concerns
by
focusing
on
the
epistemological
question
of
whether
possess
structures
for
morally-relevant
that
bear
resemblance
those
found
in
human
brains.
Critics
challenge
this
similarity
philosophical,
scientific,
practical
grounds
but
do
so
without
a
suitable
alternative.
Here,
I
introduce
an
architectural
infers
potential
cognitive-like
processing
based
pattern
information
flow
through
system.
The
kind
computational
architecture
acquired
organoid
then
informs
could,
theoretically,
be
supported
empirically
investigated.
implications
considerability
are
discussed.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Culturing
neuronal
networks
in
vitro
is
a
tedious
and
time-consuming
endeavor.
In
addition,
how
the
composition
of
culture
medium
environmental
variables
such
as
temperature,
osmolarity,
pH
affect
spiking
behavior
cultures
difficult
to
study
using
electrophysiology.
this
work,
we
present
“inkube”,
an
incubation
system
that
has
been
combined
with
electrophysiology
setup
fully
automatic
perfusion
system.
This
allows
for
precise
measurement
control
temperature
up
4
microelectrode
arrays
(MEAs)
parallel.
activity
can
be
electrically
induced
recorded
from
MEAs.
inkube
continuously
monitor
level
automatically
readjust
osmolarity.
Using
inkube’s
unique
capability
precisely
neural
culture,
found
evaporation
influences
response.
Moreover,
decreasing
by
only
1.5°C
significantly
affected
spike
latency,
measure
commonly
used
show
plasticity
experiments.
We
finally
provide
proof-of-concept
experiment
drug
screening
applications,
where
varies
concentration
magnesium
ions
medium.
Given
its
high
autonomy,
record,
stimulate,
without
user
intervention.
Both
hardware
software
are
completely
open-source.
Highlights
Low-cost,
open-hardware/open-software
Full
solution:
Temperature,
CO
2
,
humidity
Perfusion
fluidic
exchange
testing
volume
feedback
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 265 - 290
Published: Dec. 17, 2024
Synthetic
biology
and
artificial
intelligence
are
ushering
in
a
new
era
of
healthcare.
In
the
specific
context
bioengineering,
organoids,
brain-computer
interfaces,
ethical
considerations
particularly
salient.
Challenges
such
as
data
inadequacy,
unintended
bias
can
undermine
reliability
fairness
decision
making.
Additionally,
cultural
barriers
concerns
related
to
nonmaleficence,
autonomy,
justice
must
be
carefully
considered.
To
fully
realize
benefits
this
technological
synergy,
multidisciplinary
approach
is
necessary,
involving
scientists,
engineers,
ethicists,
policymakers.
Transparent
accountable
AI
systems
essential
mitigate
biases,
protect
privacy,
avoid
consequences.
By
proactively
addressing
developing
robust
regulatory
frameworks,
we
harness
power
these
technologies
for
betterment
humanity.
