Cellular mechanisms of age-dependent bone remodeling DOI Open Access
Н. Г. Плехова, Polina A. Krivolutskaya, I. N. Chernenko

et al.

Kazan medical journal, Journal Year: 2024, Volume and Issue: 105(4), P. 648 - 660

Published: July 25, 2024

The structural integrity of the skeleton is ensured by constant remodeling bone tissue, which based on functioning and interaction osteolytic cells (osteoclasts) tissue forming (osteoblasts/osteocytes). Despite general understanding that degree mineralization matrix determines fragility skeleton, there currently insufficient information about its age-related changes associated with these cells. purpose review to evaluate existing data functional state mesenchymal stem cells, osteoblasts/osteocytes osteoclasts. Inclusion criteria: randomized or non-randomized controlled studies examining change. A search for in field condition was carried out electronic scientific databases Google Scholar, Medline, PubMed, Scopus, Web Science Cochrane Library keywords their combinations using AMSTAR 2 program. selection publications (59 680 included) randomly, after three authors independently assessed methodological quality. main pathogenetic mechanism involved loss age a decrease formation osteoblasts impairment ability osteogenic differentiation. Osteocytes old are subject excessive prolonged stress, causes unbalanced autophagy apoptosis, leads deposit mineralize extracellular organic matrix. With age, accelerated osteoclastogenesis occurs, mediated osteoblasts, increased expression certain receptors at level stromal osteoblasts. presented literature demonstrate convincing evidence an increase resorption due complex metabolic processes occurs against background number activity osteoclasts, apoptosis activity, as well redistribution differentiation towards adipocytes. results can be used basis developing diagnostic criteria identifying senile osteoporosis risk fractures.

Language: Английский

Microenvironment-targeted strategy steers advanced bone regeneration DOI Creative Commons

Shuyue Hao,

Mingkai Wang,

Zhifeng Yin

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100741 - 100741

Published: July 20, 2023

Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Traditional strategies tissue engineering have focused primarily on mimicking the extracellular matrix (ECM) terms structure composition. However, synergistic effects other cues from microenvironment during regeneration are often neglected. The is sophisticated system that includes physiological (e.g., neighboring cells such as macrophages), chemical oxygen, pH), physical factors mechanics, acoustics) dynamically interact with each other. Microenvironment-targeted increasingly recognized crucial for successful offer promising solutions advancing engineering. This review provides comprehensive overview current microenvironment-targeted challenges further outlines prospective directions approaches construction organoids.

Language: Английский

Citations

31
The critical role of nano-hydroxyapatites as an advanced scaffold in drug delivery towards efficient bone regeneration: Recent progress and challenges DOI Creative Commons

Amir Hatami kaleshtari,

Samira Farjaminejad,

Melika Hasani

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100692 - 100692

Published: Jan. 1, 2025

Language: Английский

Citations

2
Divalent metal ions enhance bone regeneration through modulation of nervous systems and metabolic pathways DOI
Ying Luo, Baoyi Liu,

Yashi Qiu

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 432 - 447

Published: Feb. 12, 2025

Language: Английский

Citations

1
Polyphosphate Nanoparticles: Balancing Energy Requirements in Tissue Regeneration Processes DOI Creative Commons
Wernér E.G. Müller, Meik Neufurth, Shunfeng Wang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(33)

Published: March 12, 2024

Abstract Nanoparticles of a particular, evolutionarily old inorganic polymer found across the biological kingdoms have attracted increasing interest in recent years not only because their crucial role metabolism but also potential medical applicability: it is polyphosphate (polyP). This ubiquitous linear composed 10–1000 phosphate residues linked by high‐energy anhydride bonds. PolyP causes induction gene activity, provides for bone mineralization, and serves as an energy supplier through enzymatic cleavage its acid bonds subsequent ATP formation. The biomedical breakthrough polyP came with development successful fabrication process, depot form, Ca‐ or Mg‐polyP nanoparticles, directly effective polymer, soluble Na‐polyP, regenerative repair healing processes, especially tissue areas insufficient blood supply. Physiologically, platelets are main vehicles nanoparticles circulating blood. To be biomedically active, these particles undergo coacervation. review overview properties applications regeneration bone, cartilage, skin. In addition to studies on animal models, first proof‐of‐concept humans chronic wounds outlined.

Language: Английский

Citations

5
Influence of Cholesterol on the Regulation of Osteoblast Function DOI Creative Commons
Alena Akhmetshina, Dagmar Kratky, Elizabeth Rendina-Ruedy

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(4), P. 578 - 578

Published: April 21, 2023

Bone is a dynamic tissue composed of cells, an extracellular matrix, and mineralized portion. Osteoblasts are responsible for proper bone formation remodeling, function. These processes endergonic require cellular energy in the form adenosine triphosphate (ATP), which derived from various sources such as glucose, fatty acids, amino acids. However, other lipids cholesterol have also been found to play critical role homeostasis can contribute overall bioenergetic capacity osteoblasts. In addition, several epidemiological studies link between elevated cholesterol, cardiovascular disease, enhanced risk osteoporosis, increased metastasis cancer patients. This review focuses on how its derivatives, cholesterol-lowering medications (statins) regulate osteoblast function formation. It highlights molecular mechanisms underlying cholesterol–osteoblast crosstalk.

Language: Английский

Citations

11
Biodegradable ultrahigh-purity magnesium and its alloy ZX00 promote osteogenesis in the medullary cavity and glycogenolysis in the liver DOI Creative Commons
Begüm Okutan, Uwe Yacine Schwarze, Hansjörg Habisch

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Magnesium (Mg)-based implants have become an attractive alternative to conventional permanent in the orthopedic field. While biocompatibility, degradation kinetics, and osseointegration of Mg-based been mostly investigated, impact products on bone remodeling potential systemic effects remains unclear. The aim this study was evaluate early mid-term local tissue responses degrading ultrahigh-purity ZX00 (Mg-Zn-Ca alloy) Mg (XHP-Mg) pins a juvenile healthy rat model. differences between implant types (degradable vs. permanent), implantation, age-related changes were investigated using titanium (Ti), sham-operated, control groups (non-intervention), respectively. Degradation XHP-Mg promote osteogenesis medullary cavity by upregulating expression levels Bmp2 Opg within 14 days post-surgery. higher rate resulted accumulation starting from day 3 upregulation different genes, particularly Ccl2 Cepbp. Besides good new formation, we found more parallel hydroxyapatite/collagen orientation along perimeter region compared Ti pins. In liver, reduced glycogen indicated that glycogenolysis, while only group showed serum glucagon level 14. Results suggest stimulate mainly via glycogenolysis genes metabolites. STATEMENT OF SIGNIFICANCE: Bioresorbable magnesium are promising candidates for interventions. Until now, few vivo studies explored how modulate responses. Herein, results demonstrate i) has crucial effect regulating cavity, ii) HAp/collagen matrix pattern group, iii) both liver. Our findings highlight dual role metabolic modulation. Nevertheless, is first report interaction liver metabolism.

Language: Английский

Citations

0
Role of glucose metabolism in amelogenesis DOI
Hiroko Ida‐Yonemochi

Journal of Oral Biosciences, Journal Year: 2025, Volume and Issue: 67(2), P. 100667 - 100667

Published: April 28, 2025

Language: Английский

Citations

0
Cellular metabolism: a link connecting cellular behaviour with the physiochemical properties of biomaterials for bone tissue engineering DOI
Shivani Chaudhary,

Doyel Ghosal,

Pravesh Tripathi

et al.

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(7), P. 2277 - 2291

Published: Jan. 1, 2023

This review highlights the importance of cell metabolism as a missing link connecting cellular behavior and physicochemical properties biomaterials serves guiding principle for designing scaffolds bone tissue engineering.

Language: Английский

Citations

6
Effects of PTH on osteoblast bioenergetics in response to glucose DOI Creative Commons

Victoria DeMambro,

Tian Li,

Vivin Karthik

et al.

Bone Reports, Journal Year: 2023, Volume and Issue: 19, P. 101705 - 101705

Published: July 24, 2023

Parathyroid hormone acts through its receptor, PTHR1, expressed on osteoblasts, to control bone remodeling. Metabolic flexibility for energy generation has been demonstrated in several cell types dependent substrate availability. Recent studies have identified a critical role PTH regulating glucose, fatty acid and amino metabolism thus stimulating both glycolysis oxidative phosphorylation. Therefore, we postulated that stimulates increased energetic output by osteoblasts either increasing or phosphorylation depending To test this hypothesis, undifferentiated differentiated MC3T3E1C4 calvarial pre-osteoblasts were treated with study osteoblast bioenergetics the presence of exogenous glucose. Significant increases acute ∼1 h treatment minimal effects glucose observed. In cells, observed was completely blocked pretreatment Glut1 inhibitor (BAY-876) resulting compensatory increase We then tested effect function complexes I II mitochondrial electron transport chain absence glycolysis. Utilizing novel plasma membrane permeability (PMP) assay, combination complex specific substrates, slight but significant basal maximal oxygen consumption rates 24 cells noted. Taken together, our data demonstrate first time chain, particularly II, during high demands osteoblasts.

Language: Английский

Citations

6
The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion DOI Creative Commons
Joonho Suh, Yun‐Sil Lee

Journal of Bone and Mineral Research, Journal Year: 2024, Volume and Issue: 39(9), P. 1205 - 1214

Published: June 22, 2024

Abstract Mitochondria in osteoblasts have been demonstrated to play multiple crucial functions bone formation from intracellular adenosine triphosphate production extracellular secretion of mitochondrial components. The present review explores the current knowledge about biology osteoblasts, including biogenesis, bioenergetics, oxidative stress generation, and dynamic changes morphology. Special attention is given recent findings, donut which actively generates mitochondrial-derived vesicles (MDVs), followed by small mitochondria MDVs. We also discuss therapeutic effects targeting osteoblast mitochondria, highlighting their potential applications improving health.

Language: Английский

Citations

2