Cell fate specification and differentiation in the adult mammalian intestine

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 39 - 53

Published: Sept. 21, 2020

Language: Английский

---

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

Frontiers in Immunology, Journal Year: 2017, Volume and Issue: 8

Published: July 27, 2017

Recent findings point towards diet having a major impact on human health. Diets can either affect the gut microbiota resulting in alterations host's physiological responses or by directly targeting host response. The microbial community mammalian is complex and dynamic system crucial for development maturation of both systemic mucosal immune responses. Therefore, interaction between available nutrients, are central regulators maintaining homeostasis fighting against invading pathogens at sites. Westernized diet, defined as high dietary intake saturated fats sucrose low fibre, represent growing health risk contributing to increased occurrence metabolic diseases e.g. diabetes obesity countries adapting westernized lifestyle. Inflammatory Bowel Diseases (IBD) asthma chronic inflammatory conditions unknown aetiology with increasing prevalence worldwide. These have multifactorial including genetic factors, environmental factors dysregulated Their cannot solely be attributed considerations implying that other such contributor. reports indicate modifications thereof, due consumption fibres, trigger regulating and/or progression conditions. While disease airways, evidence indicates link airways development. Herein, we provide comprehensive review associated nutrients cell how these influence pathology IBD asthma.

Language: Английский

---

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 106, P. 256 - 276

Published: Aug. 4, 2016

In this contribution, we review the molecular and physiological barriers to oral delivery of peptides nanoparticles. We discuss opportunities predictivity various in vitro systems with special emphasis on human intestine Ussing chambers. First, constraints peptide absorption are discussed. Then examined. These include gastric intestinal environment, mucus barrier, tight junctions between epithelial cells, enterocytes epithelium, subepithelial tissue. Recent data from proteome studies used provide information about protein expression profiles different nanoparticle absorption. Strategies that have been employed increase across each Special consideration is given attempts at utilizing endogenous transcytotic pathways. To reliably translate or permeability vivo situation a subject, experimental system needs realistically capture central aspects mentioned barriers. Therefore, characteristics common cell culture discussed compared those tissues. Attempts use tissue models for vitro–in extrapolation reviewed.

Language: Английский

---

ESPEN micronutrient guideline

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(6), P. 1357 - 1424

Published: Feb. 26, 2022

Language: Английский

---

Influence of In Vitro Digestion on Composition, Bioaccessibility and Antioxidant Activity of Food Polyphenols—A Non-Systematic Review

Nutrients, Journal Year: 2020, Volume and Issue: 12(5), P. 1401 - 1401

Published: May 13, 2020

There is increased interest in following a healthy lifestyle and consuming substantial portion of secondary plant metabolites, such as polyphenols, due to their benefits for the human body. Food products enriched with various forms fruits vegetables are sources pro-health components. Nevertheless, many cases, level activities changed vivo conditions. The changes strictly connected processes digestive system that transfigure structure active compounds simultaneously keep or modify biological activities. Much attention has focused on bioavailability, prerequisite further physiological functions. As studies time consuming, costly restricted by ethical concerns, vitro models investigating effects digestion these have been developed predict release from food matrix, well bioaccessibility. Most typically, simulate oral cavity, stomach, small intestine and, occasionally, large intestine. presented review aims discuss impact composition, bioaccessibility antioxidant activity polyphenols. Additionally, we consider influence pH aforementioned substances.

Language: Английский

---

Tissue Homeostasis and Inflammation

Annual Review of Immunology, Journal Year: 2021, Volume and Issue: 39(1), P. 557 - 581

Published: March 2, 2021

There is a growing interest in understanding tissue organization, homeostasis, and inflammation. However, despite an abundance of data, the organizing principles biology remain poorly defined. Here, we present perspective on organization based relationships between cell types functions that they perform. We provide formal definition homeostasis as collection circuits regulate specific variables within environment, describe how functional tissues allows for maintenance both systemic homeostasis. This leads to natural inflammation response deviations from cannot be reversed by homeostatic mechanisms alone. inflammatory signals act same cellular involved normal order coordinate emergency responses perturbations ultimately return system state. Finally, consider hierarchy implications development diseases.

Language: Английский

---

A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models

Nutrients, Journal Year: 2020, Volume and Issue: 12(3), P. 762 - 762

Published: March 13, 2020

Zinc absorption in the small intestine is one of main mechanisms regulating systemic homeostasis this essential trace element. This review summarizes key aspects human zinc and distribution. In particular, current knowledge on intestinal influence diet-derived factors bioaccessibility bioavailability as well intrinsic luminal basolateral with an impact uptake are discussed. Their investigation increasingly performed using vitro cellular models, which continually being refined keep gaining importance for studying transport via epithelium. The vast majority these models based cell line Caco-2 combination other relevant components epithelium, such mucin-secreting goblet cells digestion applying improved compositions apical media to mimic vivo situation closely possible. Particular emphasis placed summarizing previous applications results comparing their data obtained humans, discussing advantages limitations.

Language: Английский

---

Advances on the antioxidant peptides from edible plant sources

Trends in Food Science & Technology, Journal Year: 2020, Volume and Issue: 99, P. 44 - 57

Published: March 2, 2020

Language: Английский

---

Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(23), P. 9259 - 9259

Published: Dec. 4, 2020

Copper is one of the most abundant basic transition metals in human body. It takes part oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining integrity blood vessels, as well iron homeostasis, antioxidant defense, neurotransmitter synthesis. may also be involved cell signaling participate modulation membrane receptor-ligand interactions, control kinase related phosphatase functions, many cellular pathways. Its role important controlling gene expression nucleus. In nervous system particular, copper myelination, by modulating synaptic activity excitotoxic death cascades induced neurotrophic factors, for various neuronal functions. Current data suggest that both excess levels deficiency can harmful, careful homeostatic important. This knowledge opens up an new area potential therapeutic interventions based on supplementation or removal neurodegenerative diseases including Wilson’s disease (WD), Menkes (MD), Alzheimer’s (AD), Parkinson’s (PD), others. However, much remains to discovered, how regulate homeostasis prevent neurodegeneration, when chelate copper, supplement it.

Language: Английский

---

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

Cell, Journal Year: 2019, Volume and Issue: 178(6), P. 1299 - 1312.e29

Published: Aug. 29, 2019

Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address fundamental question of how gut microbes nutrition, key regulators host physiology, affect effects metformin. Combining two tractable genetic models, bacterium E. coli nematode C. elegans, we developed high-throughput four-way screen define underlying host-microbe-drug-nutrient interactions. show that integrate cues from metformin diet through phosphotransferase signaling pathway converges on transcriptional regulator Crp. A detailed experimental characterization downstream Crp in combination with metabolic modeling microbiota metformin-treated diabetic patients predicts production microbial agmatine, lipid metabolism lifespan. Our screening platform paves way identifying exploitable drug-nutrient-microbiome interactions improve health longevity targeted microbiome therapies.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI3OGQ0MjNhNTMzNGQyZmYxYTZiNTdlNmY2MmYxMzM3ZSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NzgzMjE5fQ.C3wdcP1TL3PapJWq4aI9LqsiS4q6cpUWw-FQ7fy9lgDmKHFywjogOw_G7SPvpjQAddWJFM3HFiFp6aC-1emmlgxKYfkZob882qDP8r0K1SoLm87Cbli3lc1G7hM9SeBcggAoLXUh0eD50eoNMejy-aonZO3owgKn92ybO60X8R38WWtkT-dE_vYa7x1RJIluwBYG7ocgruTrQ13ku0YQCB8I7s963G-jxU4aVCrfH2_2dj3oHNkmUYfkHx-WxMZiw6prSCAo2MxN0khMxAHYyi5KTpJGSVJwcQVLnY4qxocw4p080sYc1DSUlXTBVUq_Z11m6HKwvf0_D0Iarevc_A(mp4, (44.92 MB) Download video

Language: Английский

---