Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)
Published: March 14, 2025
Language: Английский
Science, Journal Year: 2021, Volume and Issue: 374(6571), P. 1070 - 1075
Published: Nov. 25, 2021
Inflammation is an integral part of animal biology. It provides critical protection from adverse environmental factors by enforcing the defense homeostasis and functional structural integrity tissues organs. Recent advances have uncovered a broad range biological processes that involve inflammatory control, calling for renewed framework inflammation beyond its classical roles in infection injury. In this Review, new perspectives on biology are discussed research directions suggested to address fundamental gaps our current understanding.
Language: Английский
Citations
403
Cell, Journal Year: 2022, Volume and Issue: 186(1), P. 194 - 208.e18
Published: Dec. 28, 2022
The diversity and complex organization of cells in the brain have hindered systematic characterization age-related changes its cellular molecular architecture, limiting our ability to understand mechanisms underlying functional decline during aging. Here, we generated a high-resolution cell atlas aging within frontal cortex striatum using spatially resolved single-cell transcriptomics quantified gene expression spatial major types these regions over mouse lifespan. We observed substantially more pronounced state, expression, non-neuronal neurons. Our data revealed signatures glial immune activation aging, particularly enriched subcortical white matter, identified both similarities notable differences cell-activation patterns induced by systemic inflammatory challenge. These results provide critical insights into inflammation brain.
Language: Английский
Citations
239
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
141
BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)
Published: Dec. 27, 2022
Abstract Obesity usually is accompanied by inflammation of fat tissue, with a prominent role visceral fat. Chronic in obese tissue lower grade than acute immune activation for clearing the from an infectious agent. It loss adipocyte metabolic homeostasis that causes resident cells supporting functions and regaining homeostasis. Initially, excess influx lipids glucose context overnutrition met growth proliferation. Eventual lipid overload hypertrophic adipocytes leads to endoplasmic reticulum stress secretion variety signals causing increased sympathetic tone, lipolysis adipocytes, uptake macrophages, matrix remodeling, angiogenesis, cell activation. Pro-inflammatory signaling system release amounts pro-inflammatory other mediators resulting enhanced tissue-protective responses. With chronic overnutrition, these protective actions are insufficient, death as well senescence several types seen. This structural damage expression or immunostimulatory components monocytes many types, contribution stromal cells. Matrix remodeling angiogenesis further intensified possibly detrimental fibrosis. The accumulation senescent also may be via eventual spread state affected neighboring microRNA-containing vesicles. Obese can viewed initially response order cope ambient nutrients restore but contribute at later stage.
Language: Английский
Citations
138
Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(7), P. 395 - 410
Published: Feb. 25, 2022
Language: Английский
Citations
130
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(19)
Published: March 11, 2022
Imaging-guided real-time monitoring of the treatment process inflammatory diseases is important for timely adjustment planning to lower unnecessary side effects and improve outcomes. However, it difficult reflect dynamic changes inflammation in vivo with enough tissue penetration depth. Here a novel nanotheranostic agent (denominated TMSN@PM) platelet membrane (PM)-coated, tempol-grafted, manganese-doped, mesoporous silica nanoparticles developed. The PM endows TMSN@PM ability target sites, which are verified by fluorescence imaging Cyanine5 carboxylic acid (Cy5)-labeled TMSN@PM. Under environment (mild acidity excess reactive oxygen species (ROS)), can scavenge ROS, thereby alleviating inflammation, degrade, release manganese ions enhanced magnetic resonance (MRI). relaxation (ΔR1 ) almost linearly correlated concentration H2 O2 , degree inflammation. This method offers non-invasive imaging-based strategy early prediction therapeutic outcomes therapy, may contribute precision medicine terms prognostic stratification future.
Language: Английский
Citations
98
Annual Review of Immunology, Journal Year: 2022, Volume and Issue: 40(1), P. 15 - 43
Published: Jan. 5, 2022
Our understanding of the functions IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our homeostasis immunity. The early findings that is a potent driver type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy asthma, have been further supported. Yet, as importance response in tissue repair has emerged, so fundamental these processes. In this review, we outline an evolving immunobiology, paying particular attention how directs network ST2 + regulatory T cells, reparative macrophages, innate lymphoid cells are development, homeostasis, repair.
Language: Английский
Citations
95
British Journal of Cancer, Journal Year: 2022, Volume and Issue: 127(2), P. 193 - 201
Published: March 15, 2022
Language: Английский
Citations
84
Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(12), P. 986 - 998
Published: Nov. 6, 2023
Language: Английский
Citations
64
Cell, Journal Year: 2024, Volume and Issue: 187(9), P. 2052 - 2078
Published: April 1, 2024
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense respond with targeted precision to perturbations induced pathogens tissue damage. Here, we review key principles underlying adaptive orchestrated distinct T cell B populations their extensions disease therapies. We discuss the intracellular intercellular processes shaping antigen specificity recognition in immune activation lymphocyte functions mediating effector memory responses. also describe how balance protective autoimmunity immunopathology, including during tolerance, response chronic stimulation, adaptation non-lymphoid tissues coordinating homeostasis. Finally, extracellular signals cell-intrinsic programs underpinning conclude summarizing advances vaccination engineering responses for therapeutic interventions. A deeper understanding of these holds promise uncovering new means improve human health.
Language: Английский
Citations
64