Molecular Mechanism of Action of Endocrine-Disrupting Chemicals on the Respiratory System DOI Open Access
Francesco Molinari, Gianluca Antonio Franco, Nicla Tranchida

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12540 - 12540

Published: Nov. 22, 2024

Endocrine-disrupting chemicals (EDCs) are a growing health hazard for humankind and respiratory in particular. Such chemical compounds present the environment food may interfere with physiological processes through interference functions of endocrine system, making humans more susceptible to various types diseases. This review aims discuss effects EDCs on system. Exposure during fetal development adulthood increases susceptibility diseases such as asthma, COPD, pulmonary fibrosis. both multiple complex ways they can act. Indeed, these induce oxidative stress, modify cell proliferation differentiation, tissue repair, modulate inflammatory response. Moreover, also break integrity blood-air barrier, allowing noxious substances penetrate into lung thus enhancing opportunity infection. In conclusion, scientific evidence available tends indicate that exposure is strongly linked initiation disease. Further research will be important discovering underlying molecular mechanisms devising preventive therapeutic measures.

Language: Английский

Efficient removal of estrone and 17β-estradiol from aqueous medium using UV irradiation-assisted fenton process DOI

Yaren Dikmen,

Meltem Şaylan, Sude Oflu

et al.

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(13), P. 7477 - 7486

Published: July 16, 2024

Language: Английский

Citations

0

Exposure to bisphenol compounds accelerates the conjugative transfer of antibiotic resistance plasmid DOI
Bingqing Yang, Jingyi Sun, Shuyao Zhu

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120002 - 120002

Published: Sept. 1, 2024

Language: Английский

Citations

0

Which is the current knowledge on man-made endocrine- disrupting chemicals in follicular fluid? An overview of effects on ovarian function and reproductive health DOI Creative Commons
Anna-Mariia Shulhai,

V.V. Bianco,

Valentina Donini

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 2, 2024

The increase in female reproductive disorders, such as polycystic ovary syndrome, endometriosis, and diminished ovarian reserve that lead to subfertility infertility, has encouraged researchers search discover their underlying causes risk factors. One of the crucial factors may influence increasing number issues is environmental pollution, particularly exposure man-made endocrine-disrupting chemicals (EDCs). EDCs can interfere with microenvironment, impacting not only granulosa cell function but also other surrounding cells follicular fluid (FF), which all play essential roles for oocyte development, maturation, overall function. FF surrounds developing oocytes within an follicle represents a dynamic milieu. are usually found biological fluids, therefore interest this respect. This narrative review examines current knowledge on specific classes EDCs, including industrial chemicals, pesticides, plasticizers, known effects hormonal signaling pathways, gene expression, mitochondrial function, oxidative stress induction, inflammation FF. We describe impact development quality, menstrual cycle regulation, effect assisted technique outcomes. potential transgenerational offspring through animal first-human studies been considered also. While significant progress made, understanding EDCs’ humans, remains limited, underscoring need further research clarify actions ovary.

Language: Английский

Citations

0

Exposure to Environmental Chemicals and Infertility Among US Reproductive-Aged Women DOI Open Access
Valérie Martinez, Irene H. Yen, Camila Alvarez

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(12), P. 1541 - 1541

Published: Nov. 21, 2024

Environmental chemical exposure has been rising over the past few decades but its impact on fertility remains uncertain. We assessed exposures to 23 common chemicals across a range of sociodemographic characteristics and their relationship with self-reported infertility. The analytic sample was non-pregnant women aged 18–49 years without history hysterectomy or oophorectomy (n = 2579) from National Health Nutrition Examination Survey (2013–2016). biospecimens dichotomized as high low levels based median. Logistic regression models estimated adjusted odds ratio (aOR) 95% confidence intervals (CIs) for association between infertility, age, race, education level, family income, smoking status. observed associations infertility cadmium [aOR: 1.88; CI: 1.02–3.47] arsenic 1.88 (1.05–3.36)]. Two pesticides hexachlorobenzene [OR: 2.04 (1.05–3.98)] oxychlordane (1.12–3.69)] were also associated in unadjusted analyses. There negative two Per- polyfluoroalkyl substances n-perfluorooctanoic acid 0.51: (0.30–0.86)] n-perfluorooctane sulfonic (0.26–0.97). Specific may contribute risk, highlighting need targeted public health strategies mitigate exposure.

Language: Английский

Citations

0

Molecular Mechanism of Action of Endocrine-Disrupting Chemicals on the Respiratory System DOI Open Access
Francesco Molinari, Gianluca Antonio Franco, Nicla Tranchida

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12540 - 12540

Published: Nov. 22, 2024

Endocrine-disrupting chemicals (EDCs) are a growing health hazard for humankind and respiratory in particular. Such chemical compounds present the environment food may interfere with physiological processes through interference functions of endocrine system, making humans more susceptible to various types diseases. This review aims discuss effects EDCs on system. Exposure during fetal development adulthood increases susceptibility diseases such as asthma, COPD, pulmonary fibrosis. both multiple complex ways they can act. Indeed, these induce oxidative stress, modify cell proliferation differentiation, tissue repair, modulate inflammatory response. Moreover, also break integrity blood-air barrier, allowing noxious substances penetrate into lung thus enhancing opportunity infection. In conclusion, scientific evidence available tends indicate that exposure is strongly linked initiation disease. Further research will be important discovering underlying molecular mechanisms devising preventive therapeutic measures.

Language: Английский

Citations

0