International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12540 - 12540
Published: Nov. 22, 2024
Endocrine-disrupting
chemicals
(EDCs)
are
a
growing
health
hazard
for
humankind
and
respiratory
in
particular.
Such
chemical
compounds
present
the
environment
food
may
interfere
with
physiological
processes
through
interference
functions
of
endocrine
system,
making
humans
more
susceptible
to
various
types
diseases.
This
review
aims
discuss
effects
EDCs
on
system.
Exposure
during
fetal
development
adulthood
increases
susceptibility
diseases
such
as
asthma,
COPD,
pulmonary
fibrosis.
both
multiple
complex
ways
they
can
act.
Indeed,
these
induce
oxidative
stress,
modify
cell
proliferation
differentiation,
tissue
repair,
modulate
inflammatory
response.
Moreover,
also
break
integrity
blood-air
barrier,
allowing
noxious
substances
penetrate
into
lung
thus
enhancing
opportunity
infection.
In
conclusion,
scientific
evidence
available
tends
indicate
that
exposure
is
strongly
linked
initiation
disease.
Further
research
will
be
important
discovering
underlying
molecular
mechanisms
devising
preventive
therapeutic
measures.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 2, 2024
The
increase
in
female
reproductive
disorders,
such
as
polycystic
ovary
syndrome,
endometriosis,
and
diminished
ovarian
reserve
that
lead
to
subfertility
infertility,
has
encouraged
researchers
search
discover
their
underlying
causes
risk
factors.
One
of
the
crucial
factors
may
influence
increasing
number
issues
is
environmental
pollution,
particularly
exposure
man-made
endocrine-disrupting
chemicals
(EDCs).
EDCs
can
interfere
with
microenvironment,
impacting
not
only
granulosa
cell
function
but
also
other
surrounding
cells
follicular
fluid
(FF),
which
all
play
essential
roles
for
oocyte
development,
maturation,
overall
function.
FF
surrounds
developing
oocytes
within
an
follicle
represents
a
dynamic
milieu.
are
usually
found
biological
fluids,
therefore
interest
this
respect.
This
narrative
review
examines
current
knowledge
on
specific
classes
EDCs,
including
industrial
chemicals,
pesticides,
plasticizers,
known
effects
hormonal
signaling
pathways,
gene
expression,
mitochondrial
function,
oxidative
stress
induction,
inflammation
FF.
We
describe
impact
development
quality,
menstrual
cycle
regulation,
effect
assisted
technique
outcomes.
potential
transgenerational
offspring
through
animal
first-human
studies
been
considered
also.
While
significant
progress
made,
understanding
EDCs’
humans,
remains
limited,
underscoring
need
further
research
clarify
actions
ovary.
International Journal of Environmental Research and Public Health,
Journal Year:
2024,
Volume and Issue:
21(12), P. 1541 - 1541
Published: Nov. 21, 2024
Environmental
chemical
exposure
has
been
rising
over
the
past
few
decades
but
its
impact
on
fertility
remains
uncertain.
We
assessed
exposures
to
23
common
chemicals
across
a
range
of
sociodemographic
characteristics
and
their
relationship
with
self-reported
infertility.
The
analytic
sample
was
non-pregnant
women
aged
18–49
years
without
history
hysterectomy
or
oophorectomy
(n
=
2579)
from
National
Health
Nutrition
Examination
Survey
(2013–2016).
biospecimens
dichotomized
as
high
low
levels
based
median.
Logistic
regression
models
estimated
adjusted
odds
ratio
(aOR)
95%
confidence
intervals
(CIs)
for
association
between
infertility,
age,
race,
education
level,
family
income,
smoking
status.
observed
associations
infertility
cadmium
[aOR:
1.88;
CI:
1.02–3.47]
arsenic
1.88
(1.05–3.36)].
Two
pesticides
hexachlorobenzene
[OR:
2.04
(1.05–3.98)]
oxychlordane
(1.12–3.69)]
were
also
associated
in
unadjusted
analyses.
There
negative
two
Per-
polyfluoroalkyl
substances
n-perfluorooctanoic
acid
0.51:
(0.30–0.86)]
n-perfluorooctane
sulfonic
(0.26–0.97).
Specific
may
contribute
risk,
highlighting
need
targeted
public
health
strategies
mitigate
exposure.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12540 - 12540
Published: Nov. 22, 2024
Endocrine-disrupting
chemicals
(EDCs)
are
a
growing
health
hazard
for
humankind
and
respiratory
in
particular.
Such
chemical
compounds
present
the
environment
food
may
interfere
with
physiological
processes
through
interference
functions
of
endocrine
system,
making
humans
more
susceptible
to
various
types
diseases.
This
review
aims
discuss
effects
EDCs
on
system.
Exposure
during
fetal
development
adulthood
increases
susceptibility
diseases
such
as
asthma,
COPD,
pulmonary
fibrosis.
both
multiple
complex
ways
they
can
act.
Indeed,
these
induce
oxidative
stress,
modify
cell
proliferation
differentiation,
tissue
repair,
modulate
inflammatory
response.
Moreover,
also
break
integrity
blood-air
barrier,
allowing
noxious
substances
penetrate
into
lung
thus
enhancing
opportunity
infection.
In
conclusion,
scientific
evidence
available
tends
indicate
that
exposure
is
strongly
linked
initiation
disease.
Further
research
will
be
important
discovering
underlying
molecular
mechanisms
devising
preventive
therapeutic
measures.