Characterization and Evaluation of Zero-Order Release System Comprising Glycero-(9,10-trioxolane)-trialeate and PLA: Opportunity for Packaging and Biomedicine Applications DOI Open Access
Olga V. Alexeeva, М. Л. Константинова, Valentina Siracusa

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3554 - 3554

Published: Dec. 20, 2024

Glycerol-(9,10-trioxolane) trioleate (OTOA) is a promising material that combines good plasticizing properties for PLA with profound antimicrobial activity, which makes it suitable application in state-of-the-art biomedical and packaging materials added functionality. On the other hand, of OTOA PLA-based antibacterial hindered by lack knowledge on kinetics release. In this work, release glycero-(9,10-trioxolane) from films 50% content was studied during incubation normal saline solution, first time, film evaluated. Morphological, thermal, structural mechanical + were corresponding using differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy tests. It confirmed DSC XRD solution does not lead to significant changes structure polymer matrix. Thus, formation more disturbed α’ crystalline phase due partial hydrolysis amorphous zones and/or most unstable crystallites PLA/OTOA semi-crystalline observed. The degree crystallinity also slightly increased at prolonged stages retained its strength after saline, slight increase elastic modulus tensile strength, accompanied decrease relative elongation break. obtained results showed could be characterized sustained amount released exceeding initial film. profile close zero-order kinetics, beneficial order provide stable drug pattern. Developed strong effect against Raoultella terrigena Escherichia coli, bacterial strains multidrug resistance behavior. resulting used variety applications, including wound dressings food packaging.

Language: Английский

Biodegradable Polymeric Nanoparticle-Based Drug Delivery Systems: Comprehensive Overview, Perspectives and Challenges DOI Open Access
Małgorzata Geszke-Moritz,

Michał Moritz

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2536 - 2536

Published: Sept. 7, 2024

In the last few decades, there has been a growing interest in use of biodegradable polymeric nanoparticles (BPNPs) as carriers for various therapeutic agents drug delivery systems. BPNPs have potential to improve efficacy numerous active by facilitating targeted desired site body. Biodegradable polymers are especially promising nanocarriers substances characterized poor solubility, instability, rapid metabolism, and system elimination. Such molecules can be efficiently encapsulated subsequently released from nanoparticles, which greatly improves their stability bioavailability. Biopolymers seem most suitable candidates used platforms, due biocompatibility biodegradability. Other unique properties include low cost, flexibility, stability, minimal side effects, toxicity, good entrapment potential, long-term controlled release. An overview summarizing research results years field successful fabrication loaded with is provided. The possible challenges involving nanoparticle under physiological conditions possibility scaling up production while maintaining quality, well future possibilities employing BPNPs, also reviewed.

Language: Английский

Citations

28
Anatomically accurate 3D printed prosthetic incus for ossicular chain reconstruction DOI Creative Commons
Masoud Mohseni-Dargah, Christopher J. Pastras, Payal Mukherjee

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: 46, P. e00393 - e00393

Published: Jan. 21, 2025

Language: Английский

Citations

1
Nanomaterials and Nanocomposites From Green Polymers DOI

Tamer M.M. Abdellatief,

Muhammad Tawalbeh

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
3-Dimensional printing and bioprinting in neurological sciences: applications in surgery, imaging, tissue engineering, and pharmacology and therapeutics DOI Creative Commons

S K Dhar,

Faraz Ahmad, Aditi Deshpande

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 9, 2025

Abstract The rapid evolution of three-dimensional printing (3DP) has significantly impacted the medical field. In neurology for instance, 3DP been pivotal in personalized surgical planning and education. Additionally, it facilitated creation implants, microfluidic devices, optogenetic probes, offering substantial implications research applications. 3D printed nasal casts are showing great promise targeted brain drug delivery. also aided creating “phantoms” aligning with advancements neuroimaging, design intricate objects investigating neurobiology sensory perception. Furthermore, emergence bioprinting (3DBP), a fusion cell biology, created new avenues neural tissue engineering. Effective ethical tissue-like biomimetic constructs enabled mechanistic, regenerative, therapeutic evaluations. While individual reviews have explored applications or 3DBP, comprehensive review encompassing success stories across multiple facets both technologies neurosurgery, neuro-regeneration lacking. This aims to consolidate recent achievements 3DBP various neurological science domains encourage interdisciplinary among neurologists, neurobiologists, engineers, order promote further exploration methodologies novel areas practice. Graphical abstract

Language: Английский

Citations

0
State‐of‐the‐Art Synthesis of Porous Polymer Materials and Their Several Fantastic Biomedical Applications: a Review DOI Open Access
Yohannis Wondwosen Ahmed, Alexandrе Loukanov, Hsieh‐Chih Tsai

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Porous polymers, including hydrogels, covalent organic frameworks (COFs), and hyper crosslinked polymers (HCPs), have become essential in biomedical research for their tunable pore architectures, large surface areas, functional versatility. This review provides a comprehensive overview of classification updated synthesis mechanisms, such as 3D printing, electrospinning, molecular imprinting. Their pivotal roles drug delivery, tissue engineering, wound healing, photodynamic/photothermal therapies, focusing on how size, distribution, architecture impact release, cellular interactions, therapeutic outcomes, are explored. Key challenges, biocompatibility, mechanical strength, controlled degradation, scalability, critically assessed alongside emerging strategies to enhance clinical potential. Finally, recent challenges future perspectives, emphasizing the broader applications porous addressed. work valuable insights advancing next-generation innovations through these materials.

Language: Английский

Citations

2
Characterization and Evaluation of Zero-Order Release System Comprising Glycero-(9,10-trioxolane)-trialeate and PLA: Opportunity for Packaging and Biomedicine Applications DOI Open Access
Olga V. Alexeeva, М. Л. Константинова, Valentina Siracusa

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3554 - 3554

Published: Dec. 20, 2024

Glycerol-(9,10-trioxolane) trioleate (OTOA) is a promising material that combines good plasticizing properties for PLA with profound antimicrobial activity, which makes it suitable application in state-of-the-art biomedical and packaging materials added functionality. On the other hand, of OTOA PLA-based antibacterial hindered by lack knowledge on kinetics release. In this work, release glycero-(9,10-trioxolane) from films 50% content was studied during incubation normal saline solution, first time, film evaluated. Morphological, thermal, structural mechanical + were corresponding using differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy tests. It confirmed DSC XRD solution does not lead to significant changes structure polymer matrix. Thus, formation more disturbed α’ crystalline phase due partial hydrolysis amorphous zones and/or most unstable crystallites PLA/OTOA semi-crystalline observed. The degree crystallinity also slightly increased at prolonged stages retained its strength after saline, slight increase elastic modulus tensile strength, accompanied decrease relative elongation break. obtained results showed could be characterized sustained amount released exceeding initial film. profile close zero-order kinetics, beneficial order provide stable drug pattern. Developed strong effect against Raoultella terrigena Escherichia coli, bacterial strains multidrug resistance behavior. resulting used variety applications, including wound dressings food packaging.

Language: Английский

Citations

0