A whole-brain Neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry DOI Open Access

Kyle Mark Jensen,

Vince D. Calhoun, Zening Fu

et al.

Published: Oct. 6, 2023

Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature schizophrenia frequently present in other major psychiatric illnesses. Studies individuals with first-episode (FEP) early psychosis (EP) have the potential to interpret aberrant connectivity associated during period minimal influence from medication confounds. The current study uses data-driven approach examine patterns functional network (FNC) multi-site dataset comprising resting-state magnetic resonance images (rs-fMRI) 117 FEP or EP 130 without disorder, as controls. Accounting for age, sex, race, head motion, multiple imaging sites, differences FNC were identified between control participants cortical (namely inferior frontal gyrus, superior medial postcentral supplementary motor area, posterior cingulate cortex, middle temporal gyri), subcortical (the caudate, thalamus, subthalamus, hippocampus), cerebellar regions. dysconnectivity reported here may indicate disruptions cortical-subcortical-cerebellar circuitry involved rudimentary cognitive functions serve reliable biomarkers psychosis.

Language: Английский

Between neurons and networks: investigating mesoscale brain connectivity in neurological and psychiatric disorders DOI Creative Commons

Ana Clara Caznok Silveira,

André Saraiva Leão Marcelo Antunes, Maria Carolina Pedro Athié

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 20, 2024

The study of brain connectivity has been a cornerstone in understanding the complexities neurological and psychiatric disorders. It provided invaluable insights into functional architecture how it is perturbed However, persistent challenge achieving proper spatial resolution, developing computational algorithms to address biological questions at multi-cellular level, scale often referred as mesoscale. Historically, neuroimaging studies have predominantly focused on macroscale, providing inter-regional connections but falling short resolving intricacies neural circuitry cellular or mesoscale level. This limitation hindered our ability fully comprehend underlying mechanisms disorders develop targeted interventions. In light this issue, review manuscript seeks bridge critical gap by delving domain neuroimaging. We aim provide comprehensive overview conditions affected aberrant connections, image acquisition techniques, feature extraction, data analysis methods that are specifically tailored further delineate potential research elucidate complex questions, with particular focus schizophrenia epilepsy. encompasses topics such dendritic spine quantification, single neuron morphology, region connectivity. showcase applicability significance techniques field neuroscience, highlighting their for gaining

Language: Английский

Citations

11
A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry DOI Creative Commons
Kyle M. Jensen, Vince D. Calhoun, Zening Fu

et al.

NeuroImage Clinical, Journal Year: 2024, Volume and Issue: 41, P. 103584 - 103584

Published: Jan. 1, 2024

Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature schizophrenia frequently present in other major psychiatric illnesses. Studies individuals with first-episode (FEP) early psychosis (EP) have the potential to interpret aberrant connectivity associated during period minimal influence from medication confounds. The current study uses data-driven whole-brain approach examine patterns functional network (FNC) multi-site dataset comprising resting-state magnetic resonance images (rs-fMRI) 117 FEP or EP 130 without disorder, as controls. Accounting for age, sex, race, head motion, multiple imaging sites, differences FNC were identified between control participants cortical (namely inferior frontal gyrus, superior medial postcentral supplementary motor area, posterior cingulate cortex, middle temporal gyri), subcortical (the caudate, thalamus, subthalamus, hippocampus), cerebellar regions. prominent pattern reduced especially noteworthy, most studies focus on regions, neglecting cerebellum. dysconnectivity reported here may indicate disruptions cortical-subcortical-cerebellar circuitry involved rudimentary cognitive functions which serve reliable correlates psychosis.

Language: Английский

Citations

8
A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity DOI Creative Commons
Victoria Shevchenko, R. Austin Benn, Robert Scholz

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 22, 2025

Language: Английский

Citations

0
IUPHAR Review: Computational Psychiatry 2.0. A new tool for Supporting Combination therapy of Psychopharmacology with Neuromodulation in Schizophrenia DOI Creative Commons
Hugo Geerts

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107718 - 107718

Published: March 1, 2025

Recent clinical trial successes in schizophrenia with non-dopaminergic agents have rejuvenated the field after a long period of unsuccesfull attempts. At same time, non-invasive neurostimulation has been increasingly applied other mental health disorders while few studies performed schizophrenia. The time arrived to consider combining psychotherapy neuromodulation. However, systematic approach optimize designs is needed. "Computational Psychiatry" defined as computational neuroscience modeling using biophysically and anatomically realistic representations key brain areas based on neuroimaging data biological knowledge. In this position paper, we will expand concept include drug exposure pharmacology combination This can be used impact active platform generates new silico biomarker, "information bandwidth", that might related outcomes assumption information processing capacity human represented by measure entropy quantifies level uncertainty associated processes. Previously shown readout model closed cortical-striatal-thalamocortical loop highly correlated changes positive symptoms antipsychotic treatment. paper present strategy how expanded Computational Psychiatry support optimization design neuromodulation psychopharmacology, well understanding mitigating placebo response.

Language: Английский

Citations

0
Altered Hemispheric Asymmetry of Functional Hierarchy in Schizophrenia DOI Creative Commons

Yi Zhen,

Hongwei Zheng, Yi Zheng

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 313 - 313

Published: March 16, 2025

Background/Objectives: Schizophrenia is a severe psychiatric disorder characterized by deficits in perception and advanced cognitive functions. Prior studies have reported abnormal lateralization cortical morphology functional connectivity schizophrenia. However, it remains unclear whether schizophrenia affects hemispheric asymmetry the hierarchical organization of connectome. Methods: Here, we apply gradient mapping framework to connectome estimate first three gradients, which characterize unimodal-to-transmodal, visual-to-somatomotor, somatomotor/default mode-to-multiple demand hierarchy axes. We then assess between-group differences intra- inter-hemispheric asymmetries these gradients. Results: find that, compared healthy controls, patients with exhibit significantly altered across multiple networks, including dorsal attention, ventral visual, control networks. Region-level analyses further reveal that show several regions prefrontal gyrus, medial superior frontal somatomotor areas. Lastly, gradients can differentiate between controls predict severity positive symptoms Conclusions: Collectively, findings suggest associated hierarchy, providing novel perspectives for understanding atypical brain

Language: Английский

Citations

0
Disrupted Hierarchical Functional Brain Organization in Affective and Psychotic Disorders: Insights from Functional Brain Gradients DOI
Joseph Kambeitz,

H. Häcker,

Linnea Hoheisel

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Patients with psychosis and depression show widespread alterations in brain resting-state functional connectivity (rs-FC), affecting both sensory higher-order regions. In this study, we investigate disruptions the hierarchical organization of networks patients psychotic affective disorders. We derived gradients, low dimensional representations rs-FC that capture cortical hierarchy, a large patient sample including clinical high-risk for (CHR-P) patients, recent-onset (ROP) (ROD) healthy controls (HC). examined regional alterations, network-level differentiation their relationship to symptoms. addition, linked case-control differences receptor expression maps explore underlying neurobiological mechanisms. All groups exhibited visual-to-sensorimotor gradient, while only ROP showed association-to-sensory gradient. CHR-P lower values ventral attention network. Additionally, combined higher somatomotor network, reduced gradient range altered between-network dispersion. ROD within-network dispersion attentional range. Correlational analysis revealed weak associations measures functioning, visual dysfunctions cognition. Furthermore maps, suggesting involvement neurotransmitter systems these disruptions. Our findings reveal transdiagnostic disease-specific organization. These indicate deficits integration across psychiatric diseases, highlighting role disease processes.

Language: Английский

Citations

0
Differences of individual gray matter networks between MCI patients who converted to AD within 3 Years and nonconverters DOI Creative Commons

Baiwan Zhou,

Yueqi Zhao, Xiaojia Wu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28874 - e28874

Published: March 29, 2024

Here we aimed to explore the differences in individual gray matter (GM) networks at baseline mild cognitive impairment patients who converted Alzheimer's disease (AD) within 3 years (MCI-C) and nonconverters (MCI-NC).

Language: Английский

Citations

2
A multiscale characterization of cortical shape asymmetries in early psychosis DOI Creative Commons
Yu‐Chi Chen, Jeggan Tiego, Ashlea Segal

et al.

Brain Communications, Journal Year: 2023, Volume and Issue: 6(1)

Published: Dec. 28, 2023

Psychosis has often been linked to abnormal cortical asymmetry, but prior results have inconsistent. Here, we applied a novel spectral shape analysis characterize asymmetries in patients with early psychosis across different spatial scales. We used the Human Connectome Project for Early dataset (aged 16-35), comprising 56 healthy controls (37 males, 19 females) and 112 (68 44 females). quantified variations of each hemisphere over frequencies general linear model compare differences between psychosis. further canonical correlation examine associations clinical symptoms. Cortical asymmetries, spanning wavelengths from about 22 75 mm, were significantly (Cohen's

Language: Английский

Citations

4
Functional gradient dysfunction in drug-naïve first-episode schizophrenia and its correlation with specific transcriptional patterns and treatment predictions DOI Creative Commons
Guanqun Yao, Jing Luo, Jing Li

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Nov. 18, 2024

First-episode schizophrenia (FES) is a progressive psychiatric disorder influenced by genetics, environmental factors, and brain function. The functional gradient deficits of drug-naïve FES its relationship to gene expression profiles treatment outcomes are unknown.

Language: Английский

Citations

1
Multivariate Association between Functional Connectivity Gradients and Cognition in Schizophrenia Spectrum Disorders DOI
Ju‐Chi Yu, Colin Hawco,

Lucy Bassman

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0