Macroscale Gradient Dysfunction in Alzheimer's Disease: Patterns With Cognition Terms and Gene Expression Profiles DOI Creative Commons
Dawei Wang, Zhuangzhuang Li, Kun Zhao

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(15)

Published: Oct. 15, 2024

ABSTRACT Macroscale functional gradient techniques provide a continuous coordinate system that extends from unimodal regions to transmodal higher‐order networks. However, the alterations of these gradients in AD and their correlations with cognitive terms gene expression profiles remain be established. In present study, we directly studied MRI data seven scanners. We adopted data‐driven meta‐analytic unveil AD‐associated changes gradients. The principal primary‐to‐transmodal was suppressed AD. Compared NCs, patients exhibited global connectome alterations, including reduced range variation, increased scores somatomotor, ventral attention, frontoparietal regions, decreased default mode network. More importantly, Gene Ontology biological processes were significantly enriched potassium ion transport protein‐containing complex remodeling. Our compelling evidence provides new perspective understanding

Language: Английский

Related factors of cognitive frailty among older adults with type 2 diabetes: a cross‐sectional study DOI Open Access
M. Y. Cheng, Yan Qiao, Bailin Yang

et al.

Psychogeriatrics, Journal Year: 2025, Volume and Issue: 25(2)

Published: Feb. 11, 2025

Abstract Background The correlation between diabetes and cognitive frailty is still controversial. purpose of this study was to explore the related factors in older adults with type 2 diabetes, provide new ideas for realising healthy ageing diabetic patients. Methods survey conducted at Mianyang Central Hospital affiliated University Electronic Science Technology China from January 15 June 30, 2024. subjects were aged 60 years or older. Cognitive assessed using Fried's phenotype Mini‐Mental State Examination. Statistical analysis plotting SPSS 25.0 R 4.3.3. Least absolute shrinkage selection operator (LASSO) regression used reduce dimensionality 30 clinical features collected, unimportant initially screened out. important non‐zero coefficients identified by LASSO included a multivariate logistic influencing Results This 301 persons diabetes. Among them, 91 (30.2%) cases occurred. Related include: age (odds ratio (OR) = 6.417, 95% CI: 1.882−21.876, P 0.003), hypomnesia (OR 2,985, 95%CI: 1.143−7.797, 0.026), depression 9.926, 4.117−23.934, < 0.001), retinopathy 6.489, 1.969−21.384, 0.002), history ketoacidosis 12.024, 1.724−83.872, 0.012). Conclusion prevalence mellitus higher. It closely age, hypomnesia, depression, ketoacidosis. Early detection risk effective intervention can incidence adverse events improve quality life

Language: Английский

Citations

0
Macroscale Gradient Dysfunction in Alzheimer's Disease: Patterns With Cognition Terms and Gene Expression Profiles DOI Creative Commons
Dawei Wang, Zhuangzhuang Li, Kun Zhao

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(15)

Published: Oct. 15, 2024

ABSTRACT Macroscale functional gradient techniques provide a continuous coordinate system that extends from unimodal regions to transmodal higher‐order networks. However, the alterations of these gradients in AD and their correlations with cognitive terms gene expression profiles remain be established. In present study, we directly studied MRI data seven scanners. We adopted data‐driven meta‐analytic unveil AD‐associated changes gradients. The principal primary‐to‐transmodal was suppressed AD. Compared NCs, patients exhibited global connectome alterations, including reduced range variation, increased scores somatomotor, ventral attention, frontoparietal regions, decreased default mode network. More importantly, Gene Ontology biological processes were significantly enriched potassium ion transport protein‐containing complex remodeling. Our compelling evidence provides new perspective understanding

Language: Английский

Citations

2