Transcranial direct current stimulation combined with alcohol cue inhibitory control training reduces the risk of early alcohol relapse: A randomized placebo-controlled clinical trial DOI Creative Commons

Macha Dubuson,

Charles Kornreich, Marie‐Anne Vanderhasselt

et al.

Brain stimulation, Journal Year: 2021, Volume and Issue: 14(6), P. 1531 - 1543

Published: Oct. 22, 2021

BackgroundApproximately half of all people with alcohol use disorder (AUD) relapse into reuse in the next few weeks after a withdrawal treatment. Brain stimulation and cognitive training represent recent forms complementary interventions context AUD.ObjectiveTo evaluate clinical efficacy five sessions 2 mA bilateral transcranial direct current (tDCS) for 20 min over dorsolateral prefrontal cortex (DLPFC) (left cathodal/right anodal) combined cue inhibitory control (ICT) as part rehabilitation. The secondary outcomes were executive functioning (e.g. response inhibition) craving intensity, two mechanisms strongly related to abstinence.MethodsA randomized trial patients (n = 125) severe AUD at treatment unit. Each patient was randomly assigned one four conditions, [verum vs. sham tDCS] x [alcohol neutral ICT] factorial design. main outcome abstinence rate or more (up year).ResultsVerum tDCS improved 2-week follow-up compared condition, independently condition (79.7% [95% CI 69.8–89.6] 60.7% 48.3–73.1]; p .02). A priori contrasts analyses revealed higher rates verum associated ICT (86.1% [31/36; 95% 74.6–97.6]) than other three conditions (64% [57/89; 54–74]). These positive effects on did not persist beyond intervention. Neither reduction nor improvement resulted specifically from prefrontal-tDCS ICT.ConclusionsAUD who received applied DLPFC showed significantly during following When specific ICT, brain may provide better outcomes.Trial RegistrationClinicalTrials.gov number NCT03447054 https://clinicaltrials.gov/ct2/show/NCT03447054.

Language: Английский

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On DOI Open Access
Barry J. Everitt, Trevor W. Robbins

Annual Review of Psychology, Journal Year: 2015, Volume and Issue: 67(1), P. 23 - 50

Published: Aug. 8, 2015

A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational use to compulsive drug-seeking habits, neurally underpinned by prefrontal cortical striatal control over seeking and taking well progression the ventral dorsal striatum. Here, in light of burgeoning, supportive evidence, reconsider elaborate this hypothesis, particular refinements our understanding mechanisms underlying goal-directed habitual seeking, influence drug-associated Pavlovian-conditioned stimuli on relapse, evidence for impairments top-down inhibitory behavior. We further review animal human studies have begun define etiological factors individual differences propensity become addicted drugs, leading description endophenotypes, especially cocaine addiction. consider prospect novel treatments promote abstinence relapse use.

Language: Английский

Citations

1040
The transition to compulsion in addiction DOI
Christian Lüscher, Trevor W. Robbins, Barry J. Everitt

et al.

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(5), P. 247 - 263

Published: March 30, 2020

Language: Английский

Citations

383
The neurobiological basis of binge-eating disorder DOI Creative Commons

Robert Kessler,

Peter H. Hutson,

Barry K. Herman

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2016, Volume and Issue: 63, P. 223 - 238

Published: Feb. 2, 2016

Relatively little is known about the neuropathophysiology of binge-eating disorder (BED). Here, evidence from neuroimaging, neurocognitive, genetics, and animal studies are reviewed to synthesize our current understanding pathophysiology BED. Binge-eating may be conceptualized as an impulsive/compulsive disorder, with altered reward sensitivity food-related attentional biases. Neuroimaging suggest there corticostriatal circuitry alterations in BED similar those observed substance abuse, including function prefrontal, insular, orbitofrontal cortices striatum. Human genetics that changes neurotransmitter networks, dopaminergic opioidergic systems, associated behaviors. Overall, suggests related maladaptation regulating motivation impulse control found other disorders. Further needed understand how activity neurocircuitry pharmacotherapies influence these systems reduce symptoms.

Language: Английский

Citations

321
Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum DOI
Robert F. Krueger, Kelsey A. Hobbs, Christopher Conway

et al.

World Psychiatry, Journal Year: 2021, Volume and Issue: 20(2), P. 171 - 193

Published: May 18, 2021

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address limitations traditional mental disorder diagnoses. These include arbitrary boundaries between and normality, co‐occurrence in the modal case, heterogeneity presentation within dis­orders, instability diagnosis patients. This paper reviews evidence on validity utility disinhibited externalizing antagonistic spectra HiTOP, which together constitute a broad superspectrum. are composed elements subsumed variety disorders described recent DSM nosologies, including most notably substance use “Cluster B” personality disorders. superspectrum ranges from normative levels impulse control self‐assertion, maladaptive disinhibition antagonism, extensive polysubstance involvement psychopathology. A rich literature supports superspectrum, spectra. encompasses common genetic influences, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, treatment response. structure these validators mirrors phenotypic with some correlates more specific or spectra, others relevant entire underlining hierarchical domain. Compared diagnostic categories, conceptualization shows improved utility, reliability, explanatory capacity, clinical applicability. one aspect general approach psychopathology offered by HiTOP can make classification useful both research clinic.

Language: Английский

Citations

200
Bio-psychosocial factors of children and adolescents with internet gaming disorder: a systematic review DOI Creative Commons
Nagisa Sugaya, Tomohiro Shirasaka, K. Takahashi

et al.

BioPsychoSocial Medicine, Journal Year: 2019, Volume and Issue: 13(1)

Published: Feb. 14, 2019

Previous large-scale studies suggest that internet gaming disorder (IGD) among children and adolescents has become an important public concern. Minors are known to be particularly susceptible problematic use owing age-related underdevelopment of cognitive control. It been shown precursors addictions appear during adolescence; therefore, prevention efforts must established targeting minors who have their first experience with addictive substances behaviors pubescence. Since the DSM-5 classification IGD in 2013, on drastically increased number. Thus, we performed updated review assess clinical implications IGD. The search included all publication years, using PubMed, MEDLINE, PsycINFO. Across studies, presence had a negative effect sleep schoolwork minors. Additionally, family factors, including quality parent-child relationships, were social factors Brain imaging indicate impaired control is associated abnormal function prefrontal cortex striatum. Persistent pathological online game from childhood may aggravate brain function; preventive care early intervention increasingly important. Although extant research supports effectiveness behavioral therapy for IGD, effective psychological urgent issue requires further research. This review, which presents findings minors, expected contribute development future useful practice field child adolescent psychiatry.

Language: Английский

Citations

159
Noninvasive brain stimulation treatments for addiction and major depression DOI Creative Commons
Katharine Dunlop, Colleen A. Hanlon, Jonathan Downar

et al.

Annals of the New York Academy of Sciences, Journal Year: 2016, Volume and Issue: 1394(1), P. 31 - 54

Published: Feb. 5, 2016

Major depressive disorder (MDD) and substance use disorders (SUDs) are prevalent, disabling, challenging illnesses for which new treatment options needed, particularly in comorbid cases. Neuroimaging studies of the functional architecture brain suggest common neural substrates underlying MDD SUDs. Intrinsic activity is organized into a set networks, two relevant to psychiatry. The salience network (SN) crucial cognitive control response inhibition, deficits SN function implicated across wide variety psychiatric disorders, including ventromedial (VMN) corresponds classic reward circuit, pathological VMN drug cues/negative stimuli seen SUDs/MDD. Noninvasive stimulation (NIBS) techniques, rTMS tDCS, have been used enhance cortico–striatal–thalamic through core nodes dorsal anterior cingulate cortex, dorsolateral prefrontal insula. Improvements both SUD symptoms ensue, cases, via enhanced control. Inhibition also appears promising preclinical quenching incentive SUDs MDD. Evolving techniques may further efficacy NIBS cases that unresponsive conventional treatments.

Language: Английский

Citations

155
Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders DOI Creative Commons
Philip Jean-Richard-dit-Bressel, Simon Killcross, Gavan P. McNally

et al.

Neuropsychopharmacology, Journal Year: 2018, Volume and Issue: 43(8), P. 1639 - 1650

Published: March 27, 2018

Punishment involves learning about the relationship between behavior and its adverse consequences. is fundamental to reinforcement learning, decision-making choice, disrupted in psychiatric disorders such as addiction, depression, psychopathy. However, little known brain mechanisms of punishment much what derived from study superficially similar, but fundamentally distinct, forms aversive fear conditioning avoidance learning. Here we outline unique conditions that support punishment, contents behavioral We consider evidence implicating GABA monoamine neurotransmitter systems, well corticostriatal, amygdala, dopamine circuits punishment. show how maladaptive processes are implicated addictions, impulse control disorders, psychopathy, anxiety, depression argue a better understanding cellular, circuit, cognitive will make important contributions next generation therapeutic approaches.

Language: Английский

Citations

147
Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder DOI

Chenxi Cai,

Kai Yuan,

Junsen Yin

et al.

Brain Imaging and Behavior, Journal Year: 2015, Volume and Issue: 10(1), P. 12 - 20

Published: Feb. 26, 2015

Language: Английский

Citations

93
Chronic methamphetamine self-administration disrupts cortical control of cognition DOI

Aurélien P. Bernheim,

Ronald E. See,

Carmela M. Reichel

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2016, Volume and Issue: 69, P. 36 - 48

Published: July 21, 2016

Language: Английский

Citations

93
The Pause-then-Cancel model of human action-stopping: Theoretical considerations and empirical evidence DOI Creative Commons
Darcy A. Diesburg, Jan R. Wessel

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 129, P. 17 - 34

Published: July 19, 2021

Language: Английский

Citations

92