The Roles of Neuroinflammation in l‐DOPA‐Induced Dyskinesia: Dissecting the Roles of NF‐κB and TNF‐α for Novel Pharmacological Therapeutic Approaches
European Journal of Neuroscience,
Journal Year:
2025,
Volume and Issue:
61(5)
Published: March 1, 2025
ABSTRACT
Levodopa‐induced
dyskinesia
(LID)
is
a
common
and
debilitating
complication
of
long‐term
Parkinson's
disease
treatment.
This
review
explores
the
roles
NF‐κB
TNF‐α
signalling
pathways
in
LID
pathophysiology
potential
therapeutic
approaches
targeting
these
mechanisms.
Chronic
levodopa
treatment
leads
to
aberrant
neuroplasticity
neuroinflammation,
involving
activation
increased
production
pro‐inflammatory
cytokines
like
TNF‐α.
glial
cells
contributes
sustained
neuroinflammation
exacerbates
dopaminergic
neuron
loss.
levels
are
elevated
brain
regions
affected
by
correlate
with
severity.
Several
compounds
involved
mitigating
modulating
pathways.
Agmatine
reduces
NMDA
receptor
expression
while
protecting
neurons.
Resveratrol
doxycycline
demonstrate
antidyskinetic
effects
attenuating
production.
The
Rho‐kinase
(ROCK)
inhibitor
fasudil
cannabinoid
2
(CB2)
agonists
also
show
efficacy
reducing
severity
neuroinflammation.
Hydrogen
gas
inhalation
decreases
cytokine
associated
LID.
These
findings
highlight
complex
interplay
between
NF‐κB,
other
neurotransmitter
systems
pathogenesis.
Targeting
through
represents
promising
strategy
for
developing
novel
treatments.
Further
research
needed
fully
elucidate
mechanisms
optimize
Language: Английский
In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders
Egyptian Journal of Medical Human Genetics,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: Jan. 20, 2025
Abstract
Background
Parkinson’s
disease
(PD)
is
a
neurodegenerative
condition
marked
by
the
gradual
degeneration
of
dopaminergic
neurons
in
substantia
nigra,
leading
to
depletion
nigra
as
well
and
decreased
activity
putamen.
This
study
aims
identify
role
putamen
non-motor
PD
symptoms
potential
therapeutic
target
PD.
Methods
Transcriptome
profiles
(dataset
number:
GSE205450,
obtained
from
postmortem
caudate
samples
forty
controls
thirty-five
patients)
were
retrieved
Gene
Expression
Omnibus
(GEO)
database.
Specifically,
we
focused
on
data
for
patients.
Differential
gene
expression
analysis
was
carried
out
using
with
Limma,
filtering
genes
|logFC|>
1
(fold
change)
p
<
0.05
(
-value).
Protein–Protein
Interaction
networks
constructed
stringDB
(combined
score
>
0.7)
analyzed
Cytoscape
hub
based
various
topological
measures
(EPC,
MCC,
MNC,
Degree,
EcCentricity).
Enrichment
conducted
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG).
Also,
transcription
factor
(TF)-hub
networks,
miRNA-hub
association
JASPAR
database,
Tarbase
DisGeNET
via
NetworkAnalyst
platform,
respectively.
Results
Seven
genes,
namely
SST
,
NPY
IL6
PVALB
ALB
NTS
TH
identified
Notable
miRNAs
included
hsa-mir-34a-5p,
hsa-mir-15a-5p,
hsa-mir-424-5p,
hsa-mir-19b-3p
while
key
factors
include
GATA2,
CREB1,
FOXC1,
FOXL1,
TID1,
NFKB1,
YY1,
SPIB,
GATA3,
STAT3
.
Conclusions
Our
findings
revealed
close
associations
between
such
major
depressive
disorder,
mood
disorders
schizophrenia.
These
may
provide
new
direction
developing
therapy
wet
lab
research
encouraged.
Language: Английский
Role of Pollution-Induced Oxidative Stress and Inflammation in Neurodegenerative Diseases, and the Mechanisms of Traditional Chinese Medicine’s Potential Remediation
Reviews of Environmental Contamination and Toxicology,
Journal Year:
2024,
Volume and Issue:
262(1)
Published: April 1, 2024
Language: Английский
Innovative Perspectives on the Use of Herbs and Spices as Illuminators of Health in the Context of Diseases
Jose Prakash Dharmian,
No information about this author
P. Ramakrishnan
No information about this author
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 13, 2024
This
comprehensive
article
embarks
on
a
global
journey
through
the
multifaceted
landscape
of
herbs
and
spices
in
disease
management.
We
explore
traditional
wisdom
emerging
scientific
evidence
behind
utilization
these
botanical
wonders.
Incorporating
detailed
case
studies
from
diverse
regions,
we
unravel
nuanced
interplay
between
cultural
practices,
natural
remedies,
pursuit
holistic
well-being.
The
synthesis
modern
research
offers
insights
into
potential
integration
healthcare
practices.
delves
molecular-level
chemical
constituents
their
applications
management
across
globe.
By
combining
knowledge
cutting-edge
research,
aim
to
intricate
chemistry
understand
how
bioactive
compounds
contribute
therapeutic
effects.
Language: Английский
Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice
Chong Yuan,
No information about this author
Hongtao Ren,
No information about this author
Kexin Hu
No information about this author
et al.
Food & Function,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
As
the
population
ages,
functional
dietary
supplements
are
increasingly
used
to
reduce
age-related
diseases,
especially
in
field
of
cognitive
impairment.
In
this
study,
a
thyroxine
(Th)-induced
aging
model
was
established,
and
effect
proanthocyanidins
(Pc)
on
impairment
mice
evaluated
based
ability,
neuroinflammation
immune
level.
The
results
showed
that
Pc
significantly
reduced
AchE
activity
compared
Model
group,
improving
learning
deficits
spatial
memory
aged
(
Language: Английский