Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011–2019 DOI
Salina Tewolde, Samuel B. Rosenberg, Josue Antonio Estrada

et al.

Autism Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

ABSTRACT Alzheimer's disease and related dementias (ADRD) are burdensome lethal conditions that have been hypothesized to be autism through shared genetic etiologies environmental risk factors. Our objective was use longitudinal Medicaid Medicare data describe the epidemiology of ADRD in publicly insured autistic adults. We used all claims encounters from 2011 2019 identify ADRD. calculated prevalence, incidence, age at onset, created survival curves. There were 90,229 adults ≥ 30 years enrolled for least 1 year and/or 267 cases. Prevalence 2.09% (95% CI: 1.99%, 2.20%) 8.11% 7.92%, 8.30%) 2019. Mean onset 59.3 (SD: 14.2). among men 58.3 13.8) 61.0 females. Incidence higher with intellectual disability no difference by sex. is a prevalent condition middle‐ older‐aged identified system. Understanding diagnostic process phenotype will important improve identification treatment.

Language: Английский

Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer’s Disease, Parkinson’s Disease, and Autism Spectrum Disorder DOI Creative Commons
Shilu Deepa Thomas, Sabna Abdalla, Nermin Eissa

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 831 - 831

Published: June 25, 2024

Histamine performs dual roles as an immune regulator and a neurotransmitter in the mammalian brain. The histaminergic system plays vital role regulation of wakefulness, cognition, neuroinflammation, neurogenesis that are substantially disrupted various neurodegenerative neurodevelopmental disorders. H3 receptor (H3R) antagonists inverse agonists potentiate endogenous release brain histamine have been shown to enhance cognitive abilities animal models several Microglial activation subsequent neuroinflammation implicated impacting embryonic adult neurogenesis, contributing development Alzheimer's disease (AD), Parkinson's (PD), autism spectrum disorder (ASD). Acknowledging importance microglia both neurodevelopment, well their by histamine, offers intriguing therapeutic target for these inhibition H3Rs has found facilitate shift from proinflammatory M1 state anti-inflammatory M2 state, leading reduction activity microglial cells. Also, pharmacological studies demonstrated H3R showed positive effects reducing biomarkers, suggesting potential simultaneously modulating crucial neurotransmissions signaling cascades such PI3K/AKT/GSK-3β pathway. In this review, we highlight addressing pathology decline disorders, e.g., AD, PD, ASD, with inflammatory component.

Language: Английский

Citations

9
Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011–2019 DOI
Salina Tewolde, Samuel B. Rosenberg, Josue Antonio Estrada

et al.

Autism Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

ABSTRACT Alzheimer's disease and related dementias (ADRD) are burdensome lethal conditions that have been hypothesized to be autism through shared genetic etiologies environmental risk factors. Our objective was use longitudinal Medicaid Medicare data describe the epidemiology of ADRD in publicly insured autistic adults. We used all claims encounters from 2011 2019 identify ADRD. calculated prevalence, incidence, age at onset, created survival curves. There were 90,229 adults ≥ 30 years enrolled for least 1 year and/or 267 cases. Prevalence 2.09% (95% CI: 1.99%, 2.20%) 8.11% 7.92%, 8.30%) 2019. Mean onset 59.3 (SD: 14.2). among men 58.3 13.8) 61.0 females. Incidence higher with intellectual disability no difference by sex. is a prevalent condition middle‐ older‐aged identified system. Understanding diagnostic process phenotype will important improve identification treatment.

Language: Английский

Citations

1