Cells,
Journal Year:
2022,
Volume and Issue:
11(24), P. 4103 - 4103
Published: Dec. 17, 2022
Inflammatory
bowel
diseases,
including
Crohn’s
disease
and
ulcerative
colitis,
are
incurable
autoimmune
diseases
characterized
by
chronic
inflammation
of
the
gastrointestinal
tract.
There
is
increasing
evidence
that
inappropriate
interaction
between
enteric
nervous
system
central
and/or
low
activity
vagus
nerve,
which
connects
systems,
could
play
a
crucial
role
in
their
pathogenesis.
Therefore,
it
has
been
suggested
appropriate
neuroprosthetic
stimulation
nerve
lead
to
modulation
tract
consequent
long-term
control
these
diseases.
In
present
paper,
we
provide
comprehensive
overview
(1)
cellular
molecular
bases
immune
system,
(2)
way
systems
interact
contribute
responses,
(3)
pathogenesis
inflammatory
disease,
(4)
therapeutic
use
stimulation,
particular,
transcutaneous
auricular
branch
nerve.
Then,
expose
working
hypotheses
for
processes
responsible
intestinal
develop
personalized
devices
procedures
favor
patients.
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
199, P. 106573 - 106573
Published: June 18, 2024
Arketamine,
the
(R)-enantiomer
of
ketamine,
exhibits
antidepressant-like
effects
in
mice,
though
precise
molecular
mechanisms
remain
elusive.
It
has
been
shown
to
reduce
splenomegaly
and
depression-like
behaviors
chronic
social
defeat
stress
(CSDS)
model
depression.
This
study
investigated
whether
spleen
contributes
arketamine
CSDS
model.
We
found
that
splenectomy
significantly
inhibited
arketamine's
CSDS-susceptible
mice.
RNA-sequencing
analysis
identified
oxidative
phosphorylation
(OXPHOS)
pathway
prefrontal
cortex
(PFC)
as
a
key
mediator
splenectomy's
impact
on
effects.
Furthermore,
oligomycin
A,
an
inhibitor
OXPHOS
pathway,
reversed
suppressive
Specific
genes
within
pathways,
such
COX11,
UQCR11
ATP5e,
may
contribute
these
inhibitory
Notably,
transforming
growth
factor
(TGF)-β1,
along
with
appears
modulate
Additionally,
SRI-01138,
agonist
TGF-β1
receptor,
alleviated
Subdiaphragmatic
vagotomy
also
counteracted
These
findings
suggest
PFC
play
significant
roles
arketamine,
mediated
through
spleen-brain
axis
via
vagus
nerve.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Aug. 30, 2022
Abstract
Imiquimod
(IMQ)
is
widely
used
as
animal
model
of
psoriasis,
a
chronic
inflammatory
skin
disorder.
Although
topical
application
IMQ
to
back
causes
splenomegaly
in
mice,
how
the
spleen
affects
psoriasis-like
phenotype
IMQ-treated
mice
remains
unclear.
In
this
study,
we
analyzed
cellular
composition
and
measured
metabolites
blood
mice.
We
also
investigated
whether
splenectomy
influences
degree
inflammation
pathology
Flow
cytometry
showed
that
numbers
CD11b
+
Ly6c
neutrophils,
Ter119
proerythroblasts,
B220
B
cells,
F4/80
macrophages,
CD11c
dendritic
cells
were
significantly
higher
compared
control
An
untargeted
metabolomics
analysis
identified
14
metabolites,
including
taurine
2,6-dihydroxybenzoic
acid,
whose
levels
distinguished
two
groups.
The
positively
correlated
with
weight
spleen.
However,
did
not
affect
IMQ-induced
phenotypes
sham-operated
although
increased
expression
interleukin-17A
mRNA
These
data
suggest
does
play
direct
role
development
on
though
splenomegaly.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(9), P. 4951 - 4951
Published: April 29, 2022
It
has
been
found
that
soluble
epoxide
hydrolase
(sEH;
encoded
by
the
EPHX2
gene)
in
metabolism
of
polyunsaturated
fatty
acids
(PUFAs)
plays
a
key
role
inflammation,
which,
turn,
part
pathogenesis
neuropsychiatric
disorders.
Meanwhile,
epoxy
such
as
epoxyeicosatrienoic
(EETs),
epoxyeicosatetraenoic
(EEQs),
and
epoxyeicosapentaenoic
(EDPs)
have
to
exert
neuroprotective
effects
animal
models
disorders
through
potent
anti-inflammatory
actions.
Soluble
expoxide
hydrolase,
an
enzyme
present
all
living
organisms,
metabolizes
into
corresponding
dihydroxy
acids,
which
are
less
active
than
precursors.
In
this
regard,
preclinical
findings
using
sEH
inhibitors
or
Ephx2
knock-out
(KO)
mice
indicated
inhibition
deficiency
can
beneficial
several
Thus,
review
discusses
current
disorders,
including
depression,
autism
spectrum
disorder
(ASD),
schizophrenia,
Parkinson’s
disease
(PD),
stroke,
well
potential
mechanisms
underlying
therapeutic
inhibitors.
Cells,
Journal Year:
2022,
Volume and Issue:
11(24), P. 4103 - 4103
Published: Dec. 17, 2022
Inflammatory
bowel
diseases,
including
Crohn’s
disease
and
ulcerative
colitis,
are
incurable
autoimmune
diseases
characterized
by
chronic
inflammation
of
the
gastrointestinal
tract.
There
is
increasing
evidence
that
inappropriate
interaction
between
enteric
nervous
system
central
and/or
low
activity
vagus
nerve,
which
connects
systems,
could
play
a
crucial
role
in
their
pathogenesis.
Therefore,
it
has
been
suggested
appropriate
neuroprosthetic
stimulation
nerve
lead
to
modulation
tract
consequent
long-term
control
these
diseases.
In
present
paper,
we
provide
comprehensive
overview
(1)
cellular
molecular
bases
immune
system,
(2)
way
systems
interact
contribute
responses,
(3)
pathogenesis
inflammatory
disease,
(4)
therapeutic
use
stimulation,
particular,
transcutaneous
auricular
branch
nerve.
Then,
expose
working
hypotheses
for
processes
responsible
intestinal
develop
personalized
devices
procedures
favor
patients.
