Inferring Multi-Organ Genetic Causal Connections using Imaging and Clinical Data through Mendelian Randomization DOI Creative Commons
Juan Shu, Rong Qin Zheng, Julio A. Chirinos

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 28, 2023

Abstract Understanding the complex causal relationships among major clinical outcomes and interplay multiple organs remains a significant challenge. By using imaging phenotypes, we can characterize functional structural architecture of human organs. Mendelian randomization (MR) provides valuable framework for inferring causality by leveraging genetic variants as instrumental variables. In this study, conducted systematic multi-organ MR analysis involving 402 traits 372 outcomes. Our revealed 184 links 58 diseases 56 across various organs, tissues, systems, including brain, heart, liver, kidney, lung, pancreas, spleen, adipose tissue, skeletal system. We identified intra-organ connections, such bidirectional between Alzheimer’s disease brain function, well inter-organ effects, impact heart on health. Metabolic disorders, diabetes, exhibited effects These findings shed light spanning providing insights into intricate organ functions

Language: Английский

The vagus nerve: An old but new player in brain–body communication DOI Creative Commons
Li Ma,

Hanbing Wang,

Kenji Hashimoto

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

10
Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice DOI Creative Commons
Shutian Zhang, Dajun Zhao, Zhaohua Yang

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 19, 2024

Sympathoexcitation contributes to myocardial remodeling in heart failure (HF). Increased circulating pro-inflammatory mediators directly act on the Subfornical organ (SFO), cardiovascular autonomic center, increase sympathetic outflow. Circulating mitochondria (C-Mito) are novel discovered for inter-organ communication. Cyclic GMP-AMP synthase (cGAS) is sensor of damaged mitochondria.

Language: Английский

Citations

7
Depression as a cardiovascular disorder: central-autonomic network, brain-heart axis, and vagal perspectives of low mood DOI Creative Commons
Gaetano Valenza

Frontiers in Network Physiology, Journal Year: 2023, Volume and Issue: 3

Published: May 16, 2023

If depressive symptoms are not caused by the physiological effects of a substance or other medical neurological conditions, they generally classified as mental disorders that target central nervous system. However, recent evidence suggests peripheral neural dynamics on cardiovascular control play causal role in regulating and processing emotions. In this perspective, we explore Central-Autonomic Network (CAN) related brain-heart interplay (BHI), highlighting their psychophysiological correlates clinical depression. Thus, suggest depression may arise from dysregulated cardiac vagal sympathovagal lead to CAN BHI dysfunctions. Therefore, treatments for should system whole, with particular emphasis dynamics.

Language: Английский

Citations

11
Intracortical brain‐heart interplay: An EEG model source study of sympathovagal changes DOI Creative Commons
Vincenzo Catrambone, Diego Candia‐Rivera, Gaetano Valenza

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(6)

Published: April 15, 2024

Abstract The interplay between cerebral and cardiovascular activity, known as the functional brain‐heart (BHI), its temporal dynamics, have been linked to a plethora of physiological pathological processes. Various computational models axis proposed estimate BHI non‐invasively by taking advantage time resolution offered electroencephalograph (EEG) signals. However, investigations into specific intracortical sources responsible for this limited, which significantly hampers existing studies. This study proposes an analytical modeling framework estimating at source‐brain level. analysis relies on low‐resolution electromagnetic tomography localization from scalp electrophysiological recordings. is then quantified correlation dynamics. Using approach, we aimed evaluate reliability estimates derived source‐localized EEG signals compared with prior findings neuroimaging methods. approach validated using experimental dataset gathered 32 healthy individuals who underwent standard sympathovagal elicitation cold pressor test. Additional resting state data 34 has analysed assess robustness reproducibility methodology. Experimental results not only confirmed previous activation brain structures affecting cardiac dynamics (e.g., insula, amygdala, hippocampus, anterior mid‐cingulate cortices) but also provided insights anatomical bases axis. In particular, show that bidirectional activity pathways communication increases during pressure respect state, mainly targeting neural oscillations in , bands. offers new perspectives investigation could shed light various pathophysiological conditions.

Language: Английский

Citations

4
Identifying Potential Drug Targets in Coronary Atherosclerosis: Insights from the Druggable Genome and Mendelian Randomization DOI
Ruikang Liu, Changqing Sun, Qingjuan Wu

et al.

Cardiovascular Drugs and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis DOI Creative Commons
Jun Zeng, Yuting Qiu,

Chengying Yang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial DOI Creative Commons
Zhongke Gu, Wenxiang Chen, Qian Lü

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 2, 2022

To investigate whether anodal high-definition transcranial current stimulation (HD-tDCS) over the left dorsolateral pre-frontal cortex (DLPFC) could modulate heart rate (HR) and heart-rate variability (HRV) in healthy young people. Forty people were enrolled this randomized crossover trial. The participants to receive HD-tDCS (n = 20) or sham DLPFC with a washout period of 1 week. Electrocardiogram (ECG) data continuously recorded 20 min before stimulation, during session (20 min), after session. HR time- frequency-domain indices HRV measured activity sympathetic parasympathetic nervous systems. Anodal induced significant decrease increase average normal-to-normal intervals (AVG NN), low-frequency (LF) power, total power (TP), LF/high-frequency (HF) ratio comparison baseline. However, had no effect on HRV. reduce may show some potential for acutely modulating cardiovascular function.

Language: Английский

Citations

15
Gut microbiota connects the brain and the heart: potential mechanisms and clinical implications DOI
Yi Zhang, Kai Huang, Jiahao Duan

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(4), P. 637 - 651

Published: Feb. 26, 2024

Language: Английский

Citations

3
Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction DOI Creative Commons
Weijie Chen, Zengzhang Liu,

Peilin Xiao

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2022, Volume and Issue: 9(6), P. 188 - 188

Published: June 10, 2022

Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that mediated by excessive vagal tone. However, series of urgent questions about CNA remain unanswered. From December 2020 to March 2022, six symptomatic SND who underwent were summarized in this report. Sequential targeting Ao-SVC GP, PMLGP, RAGP, and LSGP was performed patients, guided fractionated intracardiac electrograms dynamically evaluated extracardiac stimulation (ECVS). The results showed GP ablation led significant increase heart rate (HR) the elimination sinus arrest evoked ECVS, while responses atrial ventricular block eliminated PMLGP LSGP. Post-procedure HR increased up 64-86% maximum an atropine test at baseline. median from Holter monitoring 52.8 ± 2.1 bpm baseline 73.0 10.4 after procedure (p = 0.012) 71.3 10.1 six-month follow-up 0.011). Bradycardia-related symptoms disappeared all follow-up. This case reveals feasibility using ECVS-assisted sequential technique indicates critical role ECVS evaluating impact on control SAN AVN.

Language: Английский

Citations

11
Disrupted resting-state functional connectivity of the thalamus in patients with coronary heart disease DOI Creative Commons
Heng‐Le Wei,

Ming-Qiang Ao,

Mengyao Wang

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(2), P. e13423 - e13423

Published: Feb. 1, 2023

Although homeostasis of the cardiovascular system is regulated by cerebral cortex via autonomic nervous system, role abnormal brain functional connectivity (FC) networks in patients with cardiac dysfunction remains unclear. Here, we report thalamus-based FC alterations and their relationship clinical characteristics coronary heart disease (CHD).We employed resting-state magnetic resonance imaging (rs-fMRI) to acquire data twenty-six CHD alongside sixteen healthy controls (HCs). Next, performed a analysis profile patterns whole brain. Subsequently, mean time series regions that survived were used determine correlations parameters CHD.We found no statistically significant differences demographic between HCs. Patients showed decreased bilateral thalami left hemisphere, encompassing supplementary motor area, superior frontal gyrus, parietal inferior middle cingulate cortex, lingual gyrus calcarine sulcus.These findings not only have implications clarifying imbalance but also provide valuable insights guide future evaluation management regulation brain-heart axis.

Language: Английский

Citations

6