Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease DOI Creative Commons
Razan Sheta,

Morgan Bérard,

Dylan Musiol

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 23, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the degeneration of dopamine neurons in substantia nigra pars compacta, leading to motor and non-motor symptoms. While symptoms such as rigidity, tremor, bradykinesia/akinesia, postural instability are well-recognized, including cognitive decline, depression, anxiety also significantly impact patients' quality life. Preclinical research utilizing animal models has been instrumental understanding PD pathophysiology exploring therapeutic interventions. Various approaches, genetic manipulations toxin-induced insults, aim recapitulate both aspects models. However, no single model fully replicates complex spectrum Behavioral assessments play crucial role evaluating impairments models, focusing on manifestation Parkinsonian phenotype. These encompass locomotor activities, behavior abnormalities, induced rotational behavior. Similarly, features assessed through tests behavioral alterations anxiety, impairment. Although numerous have developed, non-human primates mammalian non-mammalian species, this review focuses testing methodologies rodent which most commonly used. Emphasizing mice rats, we highlight key strategies significance each method addressing specific questions interpreting experimental data. By providing comprehensive overview these aims advance foster progress research.

Language: Английский

The monoterpenoids of Paeoniae radix rubra alleviate dopaminergic neuronal injury of Parkinson's disease by inhibiting Bach1 and activating Nrf2/ARE pathway DOI
Xuwen Liu, Xinyuan Li, Mengmeng Li

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 63, P. 105808 - 105808

Published: Jan. 1, 2025

Language: Английский

Citations

2
LINC02282 promotes DNA methylation of TRIM6 by recruiting DNMTs to inhibit the progression of Parkinson's disease DOI Creative Commons
Lu Han, Chuansheng Zhao,

Jin Feng

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111224 - 111224

Published: Jan. 1, 2025

Parkinson's disease (PD) is the second most common neurodegenerative disease. Long non-coding RNAs (lncRNAs) are closely linked to occurrence and development of diseases, while underlying mechanisms remain elusive. The goal present study was elucidate mechanism by which LINC02282, a significantly downregulated lncRNA in GEO database, elicits neuroprotective effects on PD. LINC02282 poorly expressed SH-SY5Y SK-N-AS cells exposed MPP+ mice injected with MPTP. overexpression plasmids inhibited apoptosis promoted proliferation cells. In addition, using an adeno-associated virus reduced neuronal damage PD mice. mainly localized nucleus, methylation tripartite motif-containing protein 6 (TRIM6) promoter inhibit TRIM6 expression. bound DNA methyltransferases (DNMTs) increases binding DNMTs promoter. Overexpression alone induced PD-like symptoms combined upregulation effect both vitro vivo. summary, alleviated injury recruiting region inhibiting

Language: Английский

Citations

2
Using Single-Cell RNA sequencing with Drosophila, Zebrafish, and mouse models for studying Alzheimer’s and Parkinson’s disease DOI Creative Commons

Faye T.C. Lau,

Rebecca Binacchi,

S. Brugnara

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
JM-20 administration to animals with lesion of the nigrostriatal dopamine pathway induced by 6-hydroxydopamine, partially reverses motor damage and oxidative stress DOI
Luis Arturo Fonseca-Fonseca, Laura Reina Taño Portuondo,

Jeney Ramírez-Sánchez

et al.

Neurological Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 11, 2025

Previous studies have shown that JM-20, a new chemical hybrid molecule, protects against rotenone and 6-hydroxydopamine (6-OHDA) neurotoxicity. Also, we demonstrated JM-20 inhibit the formation of toxic alpha-synuclein aggregated species aminochrome cytotoxicity. The present study sought to determine neuroprotective property in animals with partial lesion nigrostriatal dopamine pathway induced by 6-OHDA. For vivo studies, adult male Wistar rats were lesioned right substantia nigra pars compacta (SNpc) 6-OHDA administration. Fifteen days after surgery, animal's asymmetry levels assessed. Those values higher than 50% divided into two groups: did not receive any treatment those administered (40 mg/kg, intragastric via gavage) for 27 days. Every 7 days, analyzed until day 42 surgery. At end experiment, euthanized, SNpc striatum taken out analysis oxidative stress. Our results reveal behavioral function progressively recovered JM-20-treated animals, diminishing percentage motor asymmetry. it improves some stress markers these animals. provides preclinical evidence support long-term potential hemiparkinson rat model, pointing its possible use as disease-modifying agent PD.

Language: Английский

Citations

0
Biosensors for Early Detection of Parkinson’s Disease: Principles, Applications, and Future Prospects DOI Creative Commons
Panpan Jiang, Nan Gao, Gang Chang

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(5), P. 280 - 280

Published: April 29, 2025

Parkinson’s disease (PD), a neurodegenerative disorder marked by the progressive loss of dopaminergic neurons in substantia nigra, imposes substantial economic burdens, including both direct and indirect costs. The medical community currently lacks definitive cure for disease, early detection is crucial timely intervention management. As innovative diagnostic tools, biosensors have shown great potential detecting PD at its stages. This review comprehensively summarizes recent advances PD, with particular focus on two key biomarkers: dopamine (DA) α-synuclein (α-syn). Furthermore, it illustrates variety nanotechnology-based biosensors, optical, electrochemical, transistor detailing their underlying principles, advantages, limitations, applications detection. Moreover, explores challenges prospects advancing diagnosis.

Language: Английский

Citations

0
Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy DOI Creative Commons
Virginia Gao, Julita Chlebowicz, Kerry Gaskin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 1, 2025

Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein's function and dysfunction in Parkinson's disease other synucleinopathies is thought to be tightly linked vesicle binding. Age the biggest risk factor for synucleinopathy, ~15% proteins have been central nervous system diseases. Yet, age- disease-induced changes vesicles remain unexplored. Via systematic analysis at ultrastructural, protein, lipid levels, we reveal specific populations, proteins, lipids over age wild-type mice α-synuclein knockout with without expression human α-synuclein. Strikingly, find several previously undescribed lacking α-synuclein, suggesting that loss contributes dysfunction. These findings not only provide insights into biology mechanisms but also serve as a baseline further mechanistic exploration disease-related alterations

Language: Английский

Citations

0
A comprehensive review of natural compounds and their structure–activity relationship in Parkinson’s disease: exploring potential mechanisms DOI Creative Commons
Rana M. Merghany, Salma A. El-Sawi,

Asmaa F. Aboul Naser

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopamine-producing cells in Substantia nigra region brain. Complementary and alternative medicine approaches have been utilized as adjuncts to conventional therapies for managing symptoms progression PD. Natural compounds gained attention their potential neuroprotective effects ability target various pathways involved pathogenesis This comprehensive review aims provide an in-depth analysis molecular targets mechanisms natural experimental models will also explore structure–activity relationship (SAR) these assess clinical studies investigating impact on individuals with The insights shared this pave way development innovative therapeutic strategies interventions

Language: Английский

Citations

2
Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease DOI Creative Commons
Razan Sheta,

Morgan Bérard,

Dylan Musiol

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 23, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the degeneration of dopamine neurons in substantia nigra pars compacta, leading to motor and non-motor symptoms. While symptoms such as rigidity, tremor, bradykinesia/akinesia, postural instability are well-recognized, including cognitive decline, depression, anxiety also significantly impact patients' quality life. Preclinical research utilizing animal models has been instrumental understanding PD pathophysiology exploring therapeutic interventions. Various approaches, genetic manipulations toxin-induced insults, aim recapitulate both aspects models. However, no single model fully replicates complex spectrum Behavioral assessments play crucial role evaluating impairments models, focusing on manifestation Parkinsonian phenotype. These encompass locomotor activities, behavior abnormalities, induced rotational behavior. Similarly, features assessed through tests behavioral alterations anxiety, impairment. Although numerous have developed, non-human primates mammalian non-mammalian species, this review focuses testing methodologies rodent which most commonly used. Emphasizing mice rats, we highlight key strategies significance each method addressing specific questions interpreting experimental data. By providing comprehensive overview these aims advance foster progress research.

Language: Английский

Citations

0