Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(9), P. 1237 - 1246

Published: Aug. 22, 2022

Language: Английский

---

Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(12), P. e0278412 - e0278412

Published: Dec. 1, 2022

Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral atrophy, improves behavioral testing performance in mouse models of AD. Here, we report data from (1) a Phase 1 feasibility study (NCT04042922, ClinicalTrials.gov) cognitively normal volunteers (n = 25), patients with mild AD dementia 16), epilepsy who underwent intracranial electrode monitoring 2) to assess safety single brief GENUS session induce entrainment (2) single-blinded, randomized, placebo-controlled 2A pilot (NCT04055376) probable 15) safety, compliance, entrainment, exploratory clinical outcomes after chronic daily sensory for 3 months. Our showed that was safe effectively induced both cortical regions other subcortical structures the hippocampus, amygdala, insula, gyrus rectus. demonstrated light sound well-tolerated compliance equally high control active groups, participants inaccurate guessing their group assignments prior unblinding. Electroencephalography recordings show our device safely dementia. After months stimulation, receiving (i) lesser ventricular dilation hippocampal (ii) increased functional connectivity default mode network well medial visual network, (iii) better on face-name association delayed recall test, (iv) improved measures activity rhythmicity compared group. These results support further evaluation pivotal trial evaluate its potential novel disease-modifying therapeutic

Language: Английский

---

Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 27(2), P. 189 - 205

Published: Dec. 19, 2022

Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior. Accordingly, tACS has vast potential for cognitive research brain disorder therapies. The generates oscillating electric fields in the that bias spike timing, causing changes local oscillatory power cross-frequency cross-area coherence. affects performance by modulating underlying single or nested rhythms, distal synchronization, metabolic activity. Clinically, tailored to abnormal oscillations shows promising results alleviating psychiatric neurological symptoms. We summarize findings of mechanisms, its use applications, novel developments personalized stimulation.

Language: Английский

---

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee

Clinical Neurophysiology, Journal Year: 2023, Volume and Issue: 150, P. 131 - 175

Published: March 30, 2023

The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. clinical diagnostic utility of transcranial magnetic stimulation: report an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on stimulation (TMS) in neurological diseases. Most TMS measures rely motor cortex and recording evoked potentials. Paired-pulse techniques, incorporating conventional amplitude-based threshold tracking, have established neurodegenerative, movement, episodic (epilepsy, migraines), chronic pain functional Cortical hyperexcitability has emerged as aid amyotrophic lateral sclerosis. Single-pulse are stroke, myelopathy even the absence radiological changes. Short-latency afferent inhibition, related to central cholinergic transmission, is reduced Alzheimer's disease. triple technique (TST) may enhance detect upper neuron involvement. potentials can be used perform mapping or preoperative assessment eloquent brain regions before surgical resection tumors. exhibits assessing lumbosacral/cervical nerve root function, especially demyelinating neuropathies, localizing site facial palsies. also high sensitivity detecting subclinical corticospinal lesions multiple Abnormalities conduction time TST correlate with impairment disability MS. Cerebellar cerebellum cerebello-dentato-thalamo-motor cortical pathways. Combining electroencephalography, novel method measure parameters altered disorders, including excitability, effective connectivity, response complexity.

Language: Английский

---

Increasing Brain Gamma Activity Improves Episodic Memory and Restores Cholinergic Dysfunction in Alzheimer's Disease

Annals of Neurology, Journal Year: 2022, Volume and Issue: 92(2), P. 322 - 334

Published: May 24, 2022

This study aimed to assess whether non-invasive brain stimulation with transcranial alternating current at gamma-frequency (γ-tACS) applied over the precuneus can improve episodic memory and modulate cholinergic transmission by modulating cerebral rhythms in early Alzheimer's disease (AD).In this randomized, double-blind, sham controlled, crossover study, 60 AD patients underwent a clinical neurophysiological evaluation including assessment of pre post minutes treatment γ-tACS targeting or tACS. In subset 10 patients, EEG analysis individualized modelling electric field distribution were carried out. Predictors efficacy evaluated.We observed significant improvement Rey Auditory Verbal Learning (RAVL) test immediate recall (p < 0.001) delayed scores after but not Face-name associations improved Short latency afferent inhibition, an indirect measure transmission, increased only 0.001). ApoE genotype baseline cognitive impairment best predictors response γ-tACS. Clinical correlated increase gamma frequencies posterior regions amount predicted precuneus.Precuneus γ-tACS, able γ-power activity on regions, showed performances, along restoration intracortical excitability measures transmission. Response was dependent genetic factors stage. ANN NEUROL 2022;92:322-334.

Language: Английский

---

Neuromodulation techniques – From non-invasive brain stimulation to deep brain stimulation

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(3), P. e00330 - e00330

Published: Feb. 9, 2024

Over the past 30 years, field of neuromodulation has witnessed remarkable advancements. These developments encompass a spectrum techniques, both non-invasive and invasive, that possess ability to probe influence central nervous system. In many cases therapies have been adopted into standard care treatments. Transcranial magnetic stimulation (TMS), transcranial direct current (tDCS), ultrasound (TUS) are most common methods in use today. Deep brain (DBS), spinal cord (SCS), vagus nerve (VNS), leading surgical for neuromodulation. Ongoing active clinical trials using uncovering novel applications paradigms these interventions.

Language: Английский

---

Modulating Gamma Oscillations Promotes Brain Connectivity to Improve Cognitive Impairment

Cerebral Cortex, Journal Year: 2021, Volume and Issue: 32(12), P. 2644 - 2656

Published: Sept. 14, 2021

Abstract Dementia causes a substantial global economic burden, but effective treatment is lacking. Recently, studies have revealed that gamma-band waves of electrical brain activity, particularly 40 Hz oscillations, are closely associated with high-order cognitive functions and can activate microglia to clear amyloid-β deposition. Here, we found compared sham stimulation, applying 40-Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) over the bilateral angular gyrus in patients probable Alzheimer’s disease (AD; n = 37) resulted up 8 weeks significantly improved function. Power spectral density analysis resting-state electroencephalography (EEG) demonstrated rTMS modulated oscillations left posterior temporoparietal region. Further testing resonance imaging TMS-EEG following: 1) prevented gray matter volume loss, 2) enhanced local functional integration within gyrus, as well middle frontal 3) strengthened information flow from region areas dynamic connectivity between anterior regions. These findings demonstrate modulating effectively improves function AD by promoting local, long-range, brain.

Language: Английский

---

Gamma Oscillations in Alzheimer’s Disease and Their Potential Therapeutic Role

Frontiers in Systems Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Dec. 13, 2021

Despite decades of research, Alzheimer’s Disease (AD) remains a lethal neurodegenerative disorder for which there are no effective treatments. This review examines the latest evidence novel and newly introduced perspective, focuses on restoration gamma oscillations investigates their potential role in treatment AD. Gamma brain activity (∼25–100 Hz) has been well-known its cognitive function, including memory, it is fundamental healthy intra-brain communication. Aberrant have observed both mice AD models human patients. A recent line work demonstrated that entrainment, through auditory visual sensory stimulation, can effectively attenuate pathology improve function disease. The first from patients indicate entrainment therapy reduce loss functional connectivity atrophy, ameliorate several pathological markers Even though research still infancy, suggests gamma-based may disease-modifying effect signified new promising era research.

Language: Английский

---

Evidence of Neuroplastic Changes after Transcranial Magnetic, Electric, and Deep Brain Stimulation

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(7), P. 929 - 929

Published: July 15, 2022

Electric and magnetic stimulation of the human brain can be used to excite or inhibit neurons. Numerous methods have been designed over years for this purpose with various advantages disadvantages that are topic review. Deep (DBS) is most direct focal application electric impulses tissue. Electrodes placed in order modulate neural activity correct parameters pathological oscillation circuits such as their amplitude frequency. Transcranial (TMS) a non-invasive alternative stimulator generating field coil scalp induces an which, turn, interacts ongoing activity. Depending upon parameters, excitation inhibition achieved. (tES) applies fields spread along skull reach brain, thus, limiting current strength avoid skin sensations cranial muscle pain. Therefore, tES only considered subthreshold, i.e., it does not directly elicit neuronal action potentials. In review, we collect hints neuroplastic changes modulation behavior, evolution clinical signs symptoms response stimulation. Possible mechanisms discussed, future paradigms suggested.

Language: Английский

---

The impact of gamma transcranial alternating current stimulation (tACS) on cognitive and memory processes in patients with mild cognitive impairment or Alzheimer's disease: A literature review

Brain stimulation, Journal Year: 2023, Volume and Issue: 16(3), P. 748 - 755

Published: April 5, 2023

Highlights•40 Hz tACS enhances gamma oscillations and memory performance in MCI/AD patients.•Active 40 increases spectral power patients over sham.•Gamma stimulation may aid clearance of tau mouse models AD patients.AbstractBackgroundTranscranial alternating current (tACS)—a noninvasive brain technique that modulates cortical through entrainment—has been demonstrated to alter oscillatory activity enhance cognition healthy adults. TACS is being explored as a tool improve patient populations with mild cognitive impairment (MCI) Alzheimer's disease (AD).ObjectiveTo review the growing body literature findings obtained from application MCI or AD, highlighting effects on function, memory, cognition. Evidence use animal also discussed. Important parameters are underscored for consideration protocols aim apply therapeutic MCI/AD.FindingsThe has shown promising results improvement processes impacted MCI/AD. These data demonstrate potential an interventional stand-alone alongside pharmacological and/or other behavioral interventions MCI/AD.ConclusionsWhile evidenced encouraging results, this function pathophysiology remains be fully determined. This explores highlights need continued research course by reinstating activity, improving processing, delaying progression, remediating abilities

Language: Английский

---