Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 5, 2024
Background
Transcutaneous
auricular
vagus
nerve
stimulation
(taVNS)
has
garnered
attention
for
stroke
rehabilitation,
with
studies
demonstrating
its
benefits
when
combined
motor
rehabilitative
training
or
delivered
before
training.
The
necessity
of
concurrently
applying
taVNS
post-stroke
rehabilitation
remains
unclear.
We
aimed
to
investigate
the
and
advantages
by
an
electromyography
(EMG)-triggered
closed-loop
system
rehabilitation.
Methods
propose
a
double-blinded,
randomized
clinical
trial
involving
150
patients
assigned
one
three
groups:
concurrent
taVNS,
sequential
sham
control
condition.
In
group,
bursts
will
synchronize
upper
extremity
movements
EMG-triggered
during
training,
while
in
session
precede
TaVNS
intensity
be
set
below
pain
threshold
both
conditions
at
zero
primary
outcome
measure
is
Fugl-Meyer
Assessment
Upper
Extremity
(FMA-UE).
Secondary
measures
include
standard
limb
function
assessments,
as
well
EMG
electrocardiogram
(ECG)
features.
Ethics
dissemination
Ethical
approval
been
granted
Medical
Committee,
affiliated
Zhujiang
Hospital
Southern
University
Clinical
Studies
(2023-QX-012-01).
This
study
registered
on
ClinicalTrials
(NCT05943431).
Signed
informed
consent
obtained
from
all
included
participants.
findings
published
peer-reviewed
journals
presented
relevant
stakeholder
conferences
meetings.
Discussion
represents
pioneering
effort
directly
comparing
impact
that
Secondly,
incorporation
enabled
automation
individualization
diverse
tasks—a
novel
approach
not
explored
previous
research.
technological
advancement
holds
promise
delivering
more
precise
tailored
interventions
patients.
However,
it
essential
acknowledge
limitation
this
study,
does
delve
into
examining
neural
mechanisms
underlying
context
Alcohol Clinical and Experimental Research,
Journal Year:
2024,
Volume and Issue:
48(9), P. 1772 - 1783
Published: July 3, 2024
Abstract
Background
Alcohol
craving
is
related
to
problematic
alcohol
use;
therefore,
pharmacotherapies
that
modulate
are
of
interest.
N
‐acetylcysteine,
an
over‐the‐counter
antioxidant,
a
candidate
pharmacotherapy
for
adolescent
use
with
the
potential
impact
craving.
Cue‐reactivity
paradigms
using
functional
magnetic
resonance
imaging
(fMRI)
can
identify
neural
regions
implicated
in
and
serve
as
screening
tool
novel
options.
Methods
This
preliminary
study
examined
effect
‐acetylcysteine
on
reactivity
cues
subjective
among
31
non‐treatment‐seeking
adolescents
(17.6–19.9
years
old,
55%
female)
who
heavily.
In
randomized
cross‐over
design,
participants
completed
three
fMRI
sessions:
baseline
after
10‐day
course
(1200
mg
twice
daily)
matched
placebo.
The
primary
outcome
was
response
versus
non‐alcohol
beverage
placebo,
secondary
self‐reported
Results
full
sample
(
n
=
31),
there
no
placebo
p
s
≥
0.49;
0.00–0.07)
or
acute
0.18,
0.06).
However,
did
reduce
generalized
0.03,
0.15).
subsample
youth
met
criteria
past‐year
disorder
19),
results
remained
unchanged.
Conclusions
may
not
alter
craving;
however,
it
general
consume
IEEE Journal of Biomedical and Health Informatics,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1285 - 1296
Published: Dec. 18, 2023
Motor
learning
plays
a
crucial
role
in
human
life,
and
various
neuromodulation
methods
have
been
utilized
to
strengthen
or
improve
it.
Transcutaneous
auricular
vagus
nerve
stimulation
(taVNS)
has
gained
increasing
attention
due
its
non-invasive
nature,
affordability
ease
of
implementation.
Although
the
potential
taVNS
on
regulating
motor
suggested,
actual
regulatory
effect
yet
fully
explored.
Electroencephalogram
(EEG)
analysis
provides
an
in-depth
understanding
cognitive
processes
involved
so
as
offer
methodological
support
for
regulation
learning.
To
investigate
learning,
this
study
recruited
22
healthy
subjects
participate
single-blind,
sham-controlled,
within-subject
serial
reaction
time
task
(SRTT)
experiment.
Every
subject
two
sessions
at
least
one
week
apart
received
20-minute
active/sham
each
session.
Behavioral
indicators
well
EEG
characteristics
during
state,
were
extracted
analyzed.
The
results
revealed
that
compared
sham
group,
active
group
showed
higher
performance.
Additionally,
indicated
after
taVNS,
motor-related
cortical
amplitudes
alpha-gamma
modulation
index
decreased
significantly
functional
connectivity
based
partial
directed
coherence
towards
frontal
lobe
was
enhanced.
These
findings
suggest
can
mainly
through
enhancing
memory
functions
rather
than
simple
movement
This
confirms
positive
which
is
particularly
promising
it
offers
avenue
skills
facilitating
rehabilitation.
BMJ Open,
Journal Year:
2024,
Volume and Issue:
14(9), P. e083986 - e083986
Published: Sept. 1, 2024
Introduction
Poststroke
shoulder
pain
is
a
common
complication
that
severely
affects
the
recovery
of
upper
limb
motor
function.
Acupuncture
has
positive
analgesic
effects
in
treating
poststroke
pain,
and
studies
have
demonstrated
efficacy
transcranial
direct
current
stimulation
(tDCS)
patients
with
this
pain.
However,
whether
acupuncture
combined
tDCS
superior
rehabilitation
effect
on
currently
unknown.
We
aimed
to
observe
intervention
explore
its
possible
central
mechanism.
Methods
analysis
This
study
describes
randomised
controlled
trial
using
assessor
blinding.
A
total
135
will
be
randomly
assigned
1:1:1
ratio
group,
group
(acupuncture
plus
tDCS).
All
three
groups
undergo
conventional
treatment.
Participants
receive
M1
area
for
20
min,
while
min
acupuncture.
The
treatment
both.
treatments
performed
five
times
per
week
4
weeks.
primary
outcome
indicator
Visual
Analogue
Scale
score.
Secondary
indicators
include
mobility,
Shoulder
Pain
Disability
Index,
Fugl–Meyer
Motor
Function
Scale,
Modified
Barthel
Index
Self-Rating
Anxiety
Depression
functional
MRI.
scale
results
assessed
at
baseline
2
weeks
weeks,
during
follow-up
1
month,
3
months
6
postdischarge.
repeated
variance
conducted
group×time
interaction
intervention.
Moreover,
MRI
applied
Ethics
dissemination
approval
was
obtained
from
Committee
Affiliated
Rehabilitation
Hospital
Fujian
University
Traditional
Chinese
Medicine
(2023KY-039–001).
published
peer-reviewed
journal
presented
scientific
conferences.
Trial
registration
number
ChiCTR2300078270.
Psychophysiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 20, 2024
Abstract
Vagus
nerve
stimulation
(VNS)
is
the
subject
of
exploration
as
an
adjunct
treatment
for
neurological
disorders
such
epilepsy,
chronic
migraine,
pain,
and
depression.
A
non‐invasive
form
VNS
transcutaneous
auricular
(taVNS).
Combining
animal
models
positron
emission
tomography
(PET)
may
lead
to
a
better
understanding
elusive
mechanisms
taVNS.
We
evaluated
acute
effect
electrical
left
vagus
via
ear
on
brain
synaptic
vesicle
glycoprotein
2A
(SV2A)
measure
presynaptic
density
glucose
metabolism
in
naïve
rats.
Female
Sprague–Dawley
rats
were
imaged
with
[
11
C]UCB‐J
(
n
=
11)
or
18
F]fluorodeoxyglucose
([
F]FDG)
PET
13)
two
separate
days,
(1)
at
baseline,
(2)
after
unilateral
taVNS
sham
(30
min).
calculated
regional
volume
distribution
(V
T
)
standard
uptake
values
(SUV)
F]FDG.
observed
reductions
binding
response
ranging
from
36%
59%.
The
changes
compared
baseline
significantly
larger
than
those
induced
by
stimulation.
differences
bilaterally
frontal
cortex,
striatum,
midbrain.
F]FDG
remained
unchanged
following
values.
This
proof‐of‐concept
study
shows
first
time
that
30
min
can
modulate
vivo
SV2A
cortical
subcortical
regions
healthy
Preclinical
disease
ligands
different
targets
be
powerful
combination
assess
therapeutic
potential
Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research,
Journal Year:
2024,
Volume and Issue:
26(1), P. e46477 - e46477
Published: Oct. 31, 2024
Introdução:
A
neuromodulação
não
invasiva
(NmNI)
abrange
um
conjunto
de
técnicas
que
modulam
a
atividade
neuronal
sem
necessidade
cirurgia
ou
implantes.
O
interesse
nessas
vem
crescendo,
especialmente
em
relação
à
sua
aplicabilidade
e
translação
resultados
protocolos
pesquisa
para
prática
clínica.
Com
isso,
surgem
questões
sobre
segurança
dos
procedimentos,
seus
efeitos
fisiológicos
os
mecanismos
ação
cerebral.
Objetivo:
Discutir
aplicabilidade,
efeitos,
as
barreiras
acesso
ao
tratamento
explorar
direções
futuras
Métodos:
Trata-se
uma
revisão
narrativa
da
literatura,
incluindo
ensaios
clínicos,
revisões
sistemáticas,
meta-análises
artigos
opinião,
com
pesquisas
nas
bases
dados
PubMed,
Scopus,
Google
Scholar
Web
of
Science.
Discussão:
As
NmNI
tendem
ser
menos
invasivas,
mais
seguras
acessíveis
do
intervenções
neurocirúrgicas,
apresentando-se
como
alternativa
às
estratégias
farmacológicas,
poucos
colaterais.
Aspectos
portabilidade,
escalabilidade
custo-benefício,
além
potencial
uso
doméstico,
devem
considerados.
Embora
amplamente
usadas
reabilitação,
ainda
é
necessário
padronizar
parâmetros
aplicação
ampliar
o
toda
população.
Conclusão:
focar
na
padronização
protocolos,
no
aprofundamento
das
neurobiológicas
expansão
novos
contextos
clínicos.
Uma
vez
limitado
por
financeiras,
geográficas
educacionais,
torna-se
essencial
criação
políticas
garantam
inclusão
saúde
pública.
