Machine Learning-Enhanced Skull-Universal Acoustic Hologram for Efficient Transcranial Ultrasound Neuromodulation Across Varied Rodent Skulls DOI
Moon Hwan Lee, Kyungsu Lee,

Youngseung Yoo

et al.

IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Journal Year: 2024, Volume and Issue: 72(1), P. 127 - 140

Published: Dec. 2, 2024

Ultrasound neuromodulation (UNM) has gained significant interest in brain science due to its non-invasive nature, precision, and deep stimulation capabilities. However, the skull poses challenges along acoustic path, leading beam distortion necessitating effective aberration correction. Acoustic holograms used with single-element ultrasound transducers offer a promising solution by enabling both correction multi-focal stimulation. A major limitation, however, is that hologram lenses designed for specific skulls may not perform well on other skulls, requiring multiple custom scaled studies. To address this, we introduce Skull-Universal Hologram (SUAH), which enables efficient transcranial UNM across various types. Our generation framework integrates physics-based hologram, differentiable simulation heterogeneous media, gradient accumulation technique. SUAH, trained range of rodent shapes, demonstrated remarkable generalizability robustness, even outperforming Skull-Specific (SSAH). Through comprehensive analyses, showed SUAH performs exceptionally well-even when smaller datasets-significantly training based individual skulls. In conclusion, shows promise as scalable, versatile, accurate tool neuromodulation, representing advancement over conventional single-skull lenses. Its ability adapt different types without need potential greatly facilitate research neuromodulation.

Language: Английский

Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology DOI

Keith R. Murphy,

Jordan S. Farrell, Jonas Bendig

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(19), P. 3252 - 3266.e5

Published: July 29, 2024

Language: Английский

Citations

24
The relationship between parameters and effects in transcranial ultrasonic stimulation. DOI Creative Commons
Tulika Nandi, Benjamin R. Kop,

Kim Butts Pauly

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

11
DORSAL RAPHE NUCLEUS CONTROLS MOTIVATIONAL STATE TRANSITIONS IN MONKEYS DOI Creative Commons

Luke Priestley,

Mark Chiew, Mo Shahdloo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 14, 2024

ABSTRACT The dorsal raphe nucleus (DRN) is an important source of serotonin in the brain but fundamental aspects its function remain elusive. Here, we present a combination minimally invasive recording and disruption studies to show that DRN brings about changes motivation states. We use recently developed methods for identifying temporal patterns behaviour monkeys change their depending on availability rewards environment. Distinctive activity occur when transition between high state occupied are abundant, low engendered by reward scarcity. Disrupting diminishes sensitivity environment perturbs transitions motivational

Language: Английский

Citations

8
Advances in transcranial focused ultrasound neuromodulation for mental disorders DOI
Yu Shi, Wen Wu

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111244 - 111244

Published: Jan. 1, 2025

Language: Английский

Citations

1
Transcranial focused ultrasound stimulation in the infralimbic cortex facilitates extinction of conditioned fear in rats DOI Creative Commons

Jaeyong Lee,

Ye Eun Kim, Jihong Lim

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(2), P. 405 - 412

Published: March 1, 2024

Transcranial focused ultrasound (tFUS) neuromodulation emerges as a promising non-invasive approach for improving neurological conditions. Extinction of conditioned fear has served prime model exposure-based therapies anxiety disorders. We investigated whether tFUS stimulation to critical brain area, the infralimbic subdivision prefrontal cortex (IL), could facilitate extinction using rats. In series experiments, was delivered IL freely-moving rat and compared sham (tFUS vs. SHAM). Initially, Fos expression in measured shortly after stimulation. The results show that significantly increased but not neighboring regions SHAM. Subsequently, two groups rats were subjected conditioning, extinction, retention while receiving during extinction. Rats group froze less than SHAM both tests. Importantly, reduced freezing attributable non-specific effect such auditory noise, demonstrated similar level locomotive activity an open field regardless condition. Finally, we replicated procedure with shortened conditioning-to-extinction interval (15 min) induce immediate deficit. showed facilitated reduction which persisted subsequent session summary, current findings suggest facilitates offering potential therapeutic regimen fear-related psychiatric

Language: Английский

Citations

4
Probing phased-array focused ultrasound transducers using realistic 3D in-silico trabecular skull models: a numerical study DOI Creative Commons
F. Rossano, Salvatore Maria Aglioti, Francesca Apollonio

et al.

Ultrasonics, Journal Year: 2025, Volume and Issue: unknown, P. 107692 - 107692

Published: May 1, 2025

Language: Английский

Citations

0
Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions DOI Creative Commons

Ruijun Wu,

F. Shi, Juan Tao

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(11), P. 3299 - 3299

Published: May 24, 2025

Transcranial focused ultrasound (TcFUS) neuromodulation is hindered by skull-induced acoustic limitations. To enable synergistic multi-region brain stimulation, we designed non-coaxial multi-focal composite Fresnel lenses, including an overlapping lens (OFL) and alternating-segmented (ASFL). These lenses convert planar into multiple foci. Based on theory, fields were analyzed via simulations experiments, validating the generation of four foci (10/30 mm focal lengths) from a 1 MHz wave using both OFL ASFL. The influence parameters pressure distribution was investigated, morphology quantified linear least-squares method. Significant differences in intensity between ASFL provide crucial guidance for optimizing multi-target TcFUS strategies.

Language: Английский

Citations

0
Focused ultrasound to the bilateral thalamus causally modulates human cognitive attention in a frequency- and intensity-dependent manner DOI Creative Commons
Kevin A. Caulfield, Christopher T. Sege, John B. Weaver

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Abstract The centromedian nucleus of the thalamus (CMT) is a core arousal center with potential for enhancing cognitive attention. While emergent focused ultrasound can reach this area, stimulation paradigms which may enhance function in humans remain unknown. Here we performed bilateral CMT using novel neuromodulation wearable device 3 distinct pulse frequencies. We found that brief 25Hz enhanced reaction time directed attention Oddball task at least 40 minutes. Pre-post electrocortical EEG revealed correlation between and prevalence related alpha theta cortical activity. Examination dose dependence bidirectional modulation state, lower intensities preferentially function. Pre- post-MRI scans showed no neuroradiological changes due to stimulation. Collectively, these findings demonstrate targeted LIFU safely healthy individuals carefully designed parameters.

Language: Английский

Citations

0
An Investigation of Parameter-Dependent Cell-Type Specific Effects of Transcranial Focused Ultrasound Stimulation Using an Awake Head-Fixed Rodent Model DOI
Sandhya Ramachandran,

Huan Gao,

Eric A. Yttri

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique able to target shallow and deep brain structures with high precision. Previous studies have demonstrated that tFUS stimulation responses are both cell-type specific controllable through altering parameters. Specifically, can elicit time-locked neural activity in regular spiking units (RSUs) sensitive increases pulse repetition frequency (PRF), while not seen fast (FSUs). These findings suggest unique capability of alter circuit network dynamics specificity; however, these results could be biased by the use anesthesia, which significantly modulates activities. In this study, we develop an awake head-fixed rat model specifically designed for address key question if still has specificity under conditions. Using novel animal model, examined series PRFs burst duty cycles (DCs) determine their effects on neuronal subpopulations without anesthesia. We conclude delayed as well PRF DC sensitivity present despite some differences response, isoflurane anesthesia major confound studying neuromodulation. further that, awake, setting, preferred inducing excitation our pulsed paradigm 1500 Hz 60%, respectively.

Language: Английский

Citations

2
Transcranial Magneto-Acoustic Stimulation Protects Synaptic Rehabilitation from Amyloid-Beta Plaques via Regulation of Microglial Functions DOI Open Access
Chunlan Zhang,

Ruxin Tan,

Xiaoqing Zhou

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4651 - 4651

Published: April 24, 2024

Transcranial magneto-acoustic stimulation (TMAS), which is characterized by high spatiotemporal resolution and penetrability, a non-invasive neuromodulation technology based on the magnetic–acoustic coupling effect. To reveal effects of TMAS treatment amyloid-beta (Aβ) plaque synaptic plasticity in Alzheimer’s disease, we conducted comparative analysis transcranial ultrasound (TUS) acoustic 5xFAD mice BV2 microglia cells. We found that TMAS-TUS effectively reduced amyloid loads plaque-associated neurotoxicity. Additionally, ameliorated impairments long-term memory formation potentiation. Moreover, stimulated microglial proliferation migration while enhancing phagocytosis clearance Aβ. In with induced exhaustion, treatment-mediated Aβ reduction, rehabilitation improvement, increase phospho-AKT levels were diminished. Overall, our study highlights hippocampal can induce anti-cognitive impairment via PI3K-AKT signaling, providing hope for development new strategies an adjuvant therapy disease.

Language: Английский

Citations

0