Resources, costs and long-term value: An integrative perspective on serotonin and meta-decision making DOI Open Access
Renée S. Koolschijn, Bertalan Polner,

Julie M Hoomans

et al.

Published: Aug. 30, 2024

Serotonin has been associated with a wide range of neural computations and behaviours, yet an overarching function this neurotransmitter hard to pinpoint. Here, we combine recent theories findings on serotonin, propose framework where serotonin integrates information resource availability state value, represent cost-benefit trade-off at the level. Critically, supports meta-decision making, i.e. flexible allocation resources decision-making. We highlight computational implementation framework, through novel lens interpret empirical in domains controllability persistence.

Language: Английский

Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology DOI

Keith R. Murphy,

Jordan S. Farrell, Jonas Bendig

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(19), P. 3252 - 3266.e5

Published: July 29, 2024

Language: Английский

Citations

17
A distributed subcortical circuit linked to instrumental information-seeking about threat DOI Creative Commons
Hailey A. Trier, Nima Khalighinejad, Sorcha Hamilton

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(3)

Published: Jan. 15, 2025

Daily life for humans and other animals requires switching between periods of threat- reward-oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturalistic task, foraging rewards seeking information about potential threats 7T fMRI healthy humans. Switching was driven by estimates likelihood threat reward. Both tracking to vigilant mode which people sought more were specific but distributed patterns spanning habenula, dorsal raphe nucleus (DRN), anterior cingulate cortex, insula cortex. Different aspects the linked monitoring level, threat, actual detection. A distinct pattern same circuit elsewhere occurred during returns Individual variation DRN reflected individual threats.

Language: Английский

Citations

2
The future of transcranial ultrasound as a precision brain interface DOI Creative Commons

Keith E. Murphy,

Elsa Fouragnan

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(10), P. e3002884 - e3002884

Published: Oct. 29, 2024

Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.

Language: Английский

Citations

4
Friend Request Accepted: Fundamental Features of Social Environments Determine Rate of Social Affiliation DOI Creative Commons
Sankalp Garud, Miruna Rascu, Sorcha Hamilton

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Humans start new friendships and social connections throughout their lives such relationships foster mental physical well-being. While friendship initiation may depend on alignment of subtle complex personal variables, here we investigated whether it also depends basic features environments. This would be analogous to other fundamental behaviours like foraging which the environment as density opportunities likelihood success. In a pre-registered online study (n=783), found people were more likely send friend requests decreased frequency success increased. Further, task-related measures, overall requests, correlated with personality-related factors thriving anhedonia. Next, in an ultra-high-field fMRI (n=24), that both environments – opportunity affected neural activity across network regions linked including dorsal raphe nucleus, substantia nigra, anterior insula. Finally, resting-state data (n=400), showed model predicted estimates anhedonia related functional connectivity between components same network. Thus, humans consider background statistics while making decisions these are ancient subcortical circuits mediating influence environmental aspects behaviour. Moreover, individual differences how behaviour associated variation personality psychiatric traits, offering insights into inter-individual variability functioning.

Language: Английский

Citations

0
Early versus late noise differentially enhances or degrades context-dependent choice DOI Creative Commons
Bo Shen, Duc Nguyen,

J. C. Wilson

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 23, 2025

Language: Английский

Citations

0
Resources, costs and long-term value: an integrative perspective on serotonin and meta-decision making DOI Creative Commons
Renée S. Koolschijn, Bertalan Polner,

Julie M Hoomans

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 60, P. 101453 - 101453

Published: Oct. 4, 2024

Language: Английский

Citations

1
Origins of noise in both improving and degrading decision making DOI Open Access
Bo Shen,

J. C. Wilson,

Duc Nguyen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Abstract Noise is a fundamental problem for information processing in neural systems. In decision-making, noise assumed to have primary role errors and stochastic choice behavior. However, little known about how arising from different sources contributes value coding behaviors, especially when it interacts with computation. Here we examine early versus late the process differentially impacts context-dependent We found model simulations that predict opposing context effects: under noise, contextual enhances accuracy; while degrades accuracy. Furthermore, verified these predictions experimental human Manipulating – by inducing uncertainty option values controlling time pressure produced dissociable positive negative effects. These findings reconcile controversial literature reporting either context-driven impairments or improvements performance, suggesting unified mechanism choice. More broadly, highlight of can interact computations modulate Significance The current study addresses origin reconciling controversies around decision-making impacted context. demonstrate types during evaluation comparison - leads distinct results: accuracy, impairs it. Understanding dynamics offers potential strategies improving noisy environments refining existing computation models. Overall, our advance understanding systems handle essential cognitive tasks, suggest beneficial modulation certain conditions, profound implications structure decision-making.

Language: Английский

Citations

0
Resources, costs and long-term value: An integrative perspective on serotonin and meta-decision making DOI Open Access
Renée S. Koolschijn, Bertalan Polner,

Julie M Hoomans

et al.

Published: Aug. 30, 2024

Serotonin has been associated with a wide range of neural computations and behaviours, yet an overarching function this neurotransmitter hard to pinpoint. Here, we combine recent theories findings on serotonin, propose framework where serotonin integrates information resource availability state value, represent cost-benefit trade-off at the level. Critically, supports meta-decision making, i.e. flexible allocation resources decision-making. We highlight computational implementation framework, through novel lens interpret empirical in domains controllability persistence.

Language: Английский

Citations

0