Predicting the Risk of nOdal disease with histological and Molecular features in Endometrial cancer: the prospective PROME trial
International Journal of Gynecological Cancer,
Journal Year:
2024,
Volume and Issue:
34(9), P. 1366 - 1372
Published: April 24, 2024
To
assess
the
role
of
histopathological
and
molecular
features
in
predicting
risk
nodal
metastases
apparent
early-stage
endometrial
cancer
patients
undergoing
sentinel
node
mapping.
This
is
a
prospective
trial.
Consecutive
with
cancer,
laparoscopic
hysterectomy,
bilateral
salpingo-oophorectomy,
mapping,
were
enrolled.
Histological
used
to
predict
positivity.
Charts
223
included
this
study.
Four
(1.8%)
excluded
from
study
due
lack
data
about
features.
Additionally,
nine
(4%)
did
not
meet
inclusion
criteria
(due
presence
peritoneal
carcinomatosis
or
bulky
nodes
(the
p53
abnormality
correlated
advanced
stage
disease
(p<0.001)).
The
population
178
(84.8%)
32
(15.2%)
endometrioid
non-endometrioid
respectively.
According
pathological
uterine
factors,
93
(44.3%),
45
(21.4%),
40
(19.1%),
classified
as
low,
intermediate,
intermediate-high,
high-risk,
Using
surrogate
classification,
10
(4.8%),
42
(20%),
57
(27.1%),
101
(48.1%)
POLE
mutated,
abnormal,
MMRd/MSI-H,
NSMP,
Overall,
41
(19.5%)
detected
positive
nodes.
Molecular
associated
having
(OR
1.03,
95%
CI
0.21
5.05,
p=0.969
for
mutated;
OR
0.788,
0.32
1.98,
p=0.602
abnormal;
1.14,
0.53
2.42,
p=0.733
MMRd/MSI-H).
At
multivariable
analysis,
only
deep
myometrial
invasion
3.318,
1.357
8.150,
p=0.009)
lymphovascular
space
6.584,
2.663
16.279,
p<0.001)
increased
Our
suggest
that
classification
does
seem
useful
tailor
need
dissection
cancer.
predicts
at
presentation.
Further
external
validation
needed.
NCT05793333.
Language: Английский
European cancer mortality predictions for the year 2025 with focus on breast cancer
Annals of Oncology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
Fraction of cancers attributable to and prevented by reproductive factors and exogenous hormones use in Italy
European Journal of Obstetrics & Gynecology and Reproductive Biology,
Journal Year:
2024,
Volume and Issue:
301, P. 49 - 54
Published: July 5, 2024
Language: Английский
Robotic-assisted, laparoscopic, and vaginal hysterectomy in morbidly obese patients with endometrial hyperplasia and endometrial cancer
Minimally Invasive Therapy & Allied Technologies,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 7
Published: Sept. 28, 2024
Hysterectomy
for
endometrial
hyperplasia
and
cancer
in
morbidly
obese
patients
is
challenging.
Here,
we
reported
data
regarding
three
minimally
invasive
approaches.
Language: Английский
Cancers attributable to diet in Italy
International Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 24, 2024
Abstract
Cancer
burden
can
be
reduced
by
controlling
modifiable
risk
factors,
including
diet.
We
provided
an
evidence‐based
assessment
of
cancer
cases
and
deaths
attributable
to
diet
in
Italy
2020.
considered
dietary
factor‐cancer
type
pairs
for
which
the
World
Research
Fund/American
Institute
–
Continuous
Update
Project
reported
either
‘convincing’
or
‘probable’
evidence
causal
association.
Relative
risks
were
retrieved
from
recent
meta‐analyses
intakes
(around
2005)
a
national
food
consumption
survey.
Sex‐specific
population
fractions
(PAFs)
computed
comparing
distribution
Italian
against
counterfactual
scenarios
based
on
recommendations.
Using
data
mortality
registries
2020,
we
estimated
number
deaths,
assuming
~15‐year
lag
period.
Unhealthy
accounted
6.3%
(95%
CI:
2.5%–9.9%)
all
men
4.5%
1.7%–7.4%)
women.
PAFs
colorectal
10.5%
7.0%
any
intake
processed
meat,
3.3%
2.0%
high
red
4.8%
4.3%
low
dairy
products,
7.9%
9.0%
fiber
women,
respectively.
non‐starchy
vegetables
fruit
ranged
0.8%
16.5%
0.6%–17.8%
women
cancers
aerodigestive
tract.
The
associated
with
unfavorable
habits
is
considerable,
but
appears
lower
than
other
high‐income
countries,
reflecting
typically
Mediterranean
Language: Английский