Integrated whole transcriptome profiling of circRNAs reveals a convoluted crosstalk in competing endogenous RNAs regulatory network in Colorectal Cancer DOI Creative Commons

Hasan Mollanoori,

Yaser Ghelmani,

Bita Hassani

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: April 4, 2023

Abstract Recently it has been identified that circRNAs can act as miRNAs sponge to regulate gene expression in various types of cancers associate with cancer initiation and progression. The present study aims identify colorectal cancer-related the underpinning mechanisms circRNA/miRNA/mRNA networks development progress Colorectal Cancer. Differentially expressed circRNAs, miRNAs, mRNAs were GEO microarray datasets using Limma package R. analysis resulted 23 upregulated 31 downregulated circRNAs. CeRNAs constructed by intersecting results predicted experimentally validated databases, circbank miRWalk, DEMs DEGs Cytoscape. Then, functional enrichment was performed for included ceRNA networks. Followed survival analysis, profile validation TCGA data, ROC curve we reached a sub-networks which revealed potential regulatory effect hsa_circ_0001955 hsa_circ_0071681 on survival-related genes, KLF4, MYC, CCNA2, RACGAP1, CD44. Overall, convoluted network likely its action CRC, may contribute developing more effective approaches early diagnosis, prognosis, treatment CRC.

Language: Английский

CircRNAs in colorectal cancer: potential biomarkers and therapeutic targets DOI Creative Commons

Yuying Zhang,

Jingyan Luo,

Weikang Yang

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(6)

Published: June 9, 2023

Abstract Globally, colorectal cancer (CRC) is the third most prevalent and second leading cause of cancer-related deaths. Circular RNAs (circRNAs) are single-stranded RNA with covalently closed-loop structures highly stable, conserved, abundantly expressed in various organs tissues. Recent research found abnormal circRNA expression CRC patients’ blood/serum, cells, tissues, exosomes. Furthermore, mounting data demonstrated that circRNAs crucial to development CRC. CircRNAs have been shown exert biological functions by acting as microRNA sponges, RNA-binding protein regulators gene splicing transcription, protein/peptide translators. These characteristics make potential markers for diagnosis prognosis, therapeutic targets, circRNA-based therapies. However, further studies still necessary improve understanding roles mechanisms In this review, up-to-date on role was examined, focusing their application targeted therapy, which would advance knowledge progression

Language: Английский

Citations

69
The opportunities and challenges in immunotherapy: Insights from the regulation of PD-L1 in cancer cells DOI Creative Commons
Qingyu Lin, Xingwen Wang, Ying Hu

et al.

Cancer Letters, Journal Year: 2023, Volume and Issue: 569, P. 216318 - 216318

Published: July 15, 2023

The immunosuppressive molecule programmed death-ligand 1 (PD-L1) is frequently upregulated in human cancers. Binding of PD-L1 to its receptor, death-1 (PD-1), on activated T cells facilitates cancer evade the host immune system. Antibody-based PD-1/PD-L1 inhibitors can inhibit interaction allowing reactivate cytotoxic eradicate advanced cells. However, majority patients fail respond anti-PD-1/PD-L1 therapies and molecular mechanisms for this remain poorly understood. Recent studies show that expression level tumor affect clinical efficacy checkpoint therapies. Thus, furthering our understanding regulatory will be critical improve response rates Here we review recent studies, primarily focusing regulate at transcriptional, post-transcriptional protein level, with purpose drive development more targeted effective

Language: Английский

Citations

54
circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer DOI
Yue Zhang, Yeru Tan, Jingping Yuan

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 592, P. 216907 - 216907

Published: April 27, 2024

Language: Английский

Citations

11
Circular RNAs in human diseases DOI Creative Commons
Yuanyong Wang, Jin Zhang, Yu‐Chen S. H. Yang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(9)

Published: Sept. 1, 2024

Abstract Circular RNAs (circRNAs) are a unique class of RNA molecules formed through back‐splicing rather than linear splicing. As an emerging field in molecular biology, circRNAs have garnered significant attention due to their distinct structure and potential functional implications. A comprehensive understanding circRNAs’ functions clinical applications remains elusive despite accumulating evidence involvement disease pathogenesis. Recent research highlights roles various human diseases, but reviews on remain scarce. This review provides in‐depth examination circRNAs, focusing first non‐neoplastic diseases such as respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, renal disorders. We then explore tumors, with particular emphasis exosomal circular RNAs, which crucial for cancer initiation, progression, resistance treatment. By detailing biogenesis, functions, impact mechanisms, this underscores the diagnostic biomarkers therapeutic targets. The not only enhances our specific tumor types also novel tools, thereby paving way future investigations interventions.

Language: Английский

Citations

9
Potential therapeutic strategy for cancer: Multi-dimensional cross-talk between circRNAs and parental genes DOI
Xiaoyu Sun, Xinyi Zhao, Yan Xu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216794 - 216794

Published: March 6, 2024

Language: Английский

Citations

8
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation DOI Creative Commons
Xixi Zeng,

Jielin Tang,

Qian Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes is implicated the pathogenesis of IBD CRC. Circular RNAs (circRNAs) have gained attention for roles various diseases, including However, comprehensive understanding specific circRNAs involved CRC, functional lacking. Here, it found that circHIPK2 (hsa_circRNA_104507) bona fide circRNA consistently upregulated CRC suggesting its potential as biomarker. Furthermore, silencing suppressed growth cells vitro vivo. Interestingly, decreased circHipk2 potentiated dextran sulfate sodium (DSS)-induced colitis but alleviated colitis-associated tumorigenesis. Most significantly, mechanistic investigations further unveil circHIPK2, mediated by FUS, interacting with EIF4A3 to promote translation TAZ, ultimately increasing transcription downstream target genes CCN1 CCN2. Taken together, emerges key player shared mechanisms modulating pathway. CircHIPK2-EIF4A3 axis contributes intestinal epithelial enhancing TAZ translation.

Language: Английский

Citations

7
Circular RNAs: implications of signaling pathways and bioinformatics in human cancer DOI Creative Commons
Fan Hu, Yin Peng,

Xinmin Fan

et al.

Cancer Biology and Medicine, Journal Year: 2023, Volume and Issue: 20(2), P. 104 - 128

Published: March 2, 2023

Circular RNAs (circRNAs) form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic cells. These mediate post-transcriptional control gene expression and have multiple functions biological processes, such as transcriptional regulation splicing. They serve predominantly microRNA sponges, RNA-binding proteins, templates for translation. More importantly, circRNAs involved cancer progression, may promising biomarkers tumor diagnosis therapy. Although traditional experimental methods usually time-consuming laborious, substantial progress has been made exploring potential circRNA-disease associations by using computational models, summarized signaling pathway data, other databases. Here, we review the characteristics circRNAs, including their roles cancer. Specifically, focus on pathways associated with carcinogenesis, status circRNA-associated bioinformatics Finally, explore prognostic

Language: Английский

Citations

15
A review of KLF4 and inflammatory disease: Current status and future perspective DOI Creative Commons

Yidan Liang,

Jiamin Zhao,

T.S. Dai

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107345 - 107345

Published: Aug. 10, 2024

Inflammation is the response of human body to injury, infection, or other abnormal states, which involved in development many diseases. As a member Krüppel-like transcription factors (KLFs) family, KLF4 plays crucial regulatory role physiological and pathological processes due its unique dual domain transcriptional activation inhibition. A growing evidence has demonstrated that pivotal pathogenesis various inflammatory disorders, including bowel disease, osteoarthritis, renal inflammation, pneumonia, neuroinflammation, so on. Consequently, emerged as promising new therapeutic target for This review systematically generalizes molecular network, specific functions, mechanisms elucidate complex roles An in-depth study on biological function anticipated offer novel research perspective potential intervention strategies

Language: Английский

Citations

5
miR-135b: A Key Role in Cancer Biology and Therapeutic Targets DOI Creative Commons

Yingchun Shao,

Shuangshuang Zhang, Yuxin Pan

et al.

Non-coding RNA Research, Journal Year: 2025, Volume and Issue: 12, P. 67 - 80

Published: Feb. 21, 2025

miR-135b, a microRNA, is consistently up-regulated in various cancer tissues and cells, promoting progression. By inhibiting one or more target genes, miR-135b regulates phenotypes such as growth, apoptosis, migration, invasion, drug resistance, angiogenesis, establishing it critical driver of Additionally, regulated by oncogenes therapeutic drugs, highlighting its complexity potential. Significant progress has been made understanding miR-135b's impact on cell behavior, promising biomarker for diagnosis prognosis, well potential future therapies. However, despite the extensive research this topic, there no comprehensive review summarizing role mechanisms across different types. This aims to provide detailed overview biological characteristics regulatory targets, upstream signaling pathways, potential, including influence chemoresistance. The also addresses key controversies surrounding research, aiming deepen role, promote transformation clinical application, theoretical foundation developing effective treatment strategies.

Language: Английский

Citations

0
Biological functions, mechanisms, and clinical significance of circular RNA in colorectal cancer DOI Creative Commons

Guida Fang,

Dalai Xu,

Tao Zhang

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: March 6, 2023

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide due to the lack effective diagnosis and prognosis biomarkers therapeutic targets, resulting in poor patient survival rates. Circular RNA (circRNA) type endogenous non-coding (ncRNA) with closed-loop structure that plays crucial role physiological processes pathological diseases. Recent studies indicate circRNAs are involved diagnosis, prognosis, drug resistance, development tumors, particularly CRC. Therefore, circRNA could be potential new target for improving CRC treatment. This review focuses on origin biological functions circRNA, summarizes recent research circRNA's CRC, discusses use as clinical well targets

Language: Английский

Citations

8