Targeting the tumor stroma for cancer therapy

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: Nov. 2, 2022

Tumors are comprised of both cancer cells and surrounding stromal components. As an essential part the tumor microenvironment, stroma is highly dynamic, heterogeneous commonly tumor-type specific, it mainly includes noncellular compositions such as extracellular matrix unique cancer-associated vascular system well a wide variety cellular components including activated fibroblasts, mesenchymal cells, pericytes. All these elements operate with each other in coordinated fashion collectively promote initiation, progression, metastasis therapeutic resistance. Over past few decades, numerous studies have been conducted to study interaction crosstalk between neoplastic cells. Meanwhile, we also witnessed exponential increase investigation recognition critical roles solid tumors. A series clinical trials targeting launched continually. In this review, introduce discuss current advances understanding various their cancers. We elaborate on potential novel approaches for tumor-stroma-based targeting, aim leap from bench bedside.

Language: Английский

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Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(9)

Published: Sept. 4, 2023

Abstract The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), cellular components include cancer non-malignant such as immune stromal cells. These three types establish complex signals in the body further influence genesis, development, metastasis participate resistance to anti-tumor therapy. It has attracted scholars study TME due significant efficacy checkpoint inhibitors (ICI) chimeric antigen receptor T (CAR-T) solid tumors hematologic tumors. After more than 10 years efforts, role strategy treating based on have developed rapidly. Moreover, ICI been recommended by guidelines first- or second-line treatment strategies a variety At same time, another major class TME, which also play very important metabolism, growth, metastasis, evasion resistance. Stromal can be recruited from neighboring non-cancerous host formed transdifferentiation they development drug secreting various factors exosomes, participating angiogenesis regulating response matrix. However, with deepening understanding cells, people found that not only effect promoting but inhibit some cases. In this review, we will introduce origin well specific mechanism tumorigenesis for We focus tumor-associated fibroblasts (CAFs), mesenchymal stem (MSCs), adipocytes (CAAs), endothelial (TECs) pericytes (PCs)

Language: Английский

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Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 12, 2024

The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate progression anti-tumor immunity. It now evident that the within TME significantly contribute resistance conventional newly developed therapies. Both in play critical roles onset, uncontrolled proliferation, metastasis, evasion, Consequently, molecular cellular components of have emerged as promising therapeutic targets for developing novel treatments. primarily comprises cells, stromal vasculature, infiltrating cells. Currently, numerous clinical trials targeting specific are underway. However, complexity its impact on evasion immunity necessitate further research develop improved multifaceted nature arises from their phenotypic functional plasticity, which endows them both pro during progression. In this review, we discuss current understanding recent advances anti-tumoral functions implications safe effective therapies control progress.

Language: Английский

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Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201

Published: Feb. 10, 2025

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.

Language: Английский

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Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999–2018 study

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

As cardiovascular disease (CVD) morbidity and mortality increase yearly, this study aimed to explore the potential of weight-adjusted-waist index (WWI) its relation long-term in patients with CVD. The diagnosis CVD was based on standardized medical condition questionnaires that incorporated participants' self-reported physician diagnoses. WWI (cm/√kg) is a continuous variable calculated as waist circumference (WC, cm) divided by square root body weight (kg). For analysis purposes, participants were into four groups quartiles (Q1 - Q4) WWI. study's primary outcome all-cause CVD, secondary outcome, sample weights complex survey designs used ensure reliable, accurate results. final included 4,445 participants. In fully adjusted model, highest quartile (WWI > 12.05 cm/√ kg) showed higher rate compared lowest < 11.03 (HR = 1.37, 95% CI: 1.03, 1.82, P 0.05). risk increased linear association congestive heart failure, attack (P-overall 0.05, nonlinear 0.05); nonlinearly associated coronary angina Survival curve further all cause high group (Q4) (P 0.001). time-dependent receiver operating characteristic (ROC) WWI's area under curves (AUC) for 5- 10-year survival rates 0.76 0.792 0.734 0.757 mortality. AUC than those mass (BMI) WC (all 0.01). Our findings indicate positively an Additionally, values strengthen meaningful prognostic marker, underscoring utility clinical practice assessing

Language: Английский

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Cancer-Associated Adipocytes and Breast Cancer: Intertwining in the Tumor Microenvironment and Challenges for Cancer Therapy

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 726 - 726

Published: Jan. 24, 2023

Adipocytes are the main components in breast tissue, and cancer-associated adipocytes (CAAs) one of most important tumor microenvironment cancer (BC). Bidirectional regulation was found between CAAs BC cells. facilitates dedifferentiation adjacent to form with morphological biological changes. increase secretion multiple cytokines adipokines promote tumorigenesis, progression, metastasis by remodeling extracellular matrix, changing aromatase expression, metabolic reprogramming, shaping immune microenvironment. also associated therapeutic response provide potential targets therapy. The present review provides a comprehensive description crosstalk discusses strategies target overcome treatment resistance.

Language: Английский

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Treatment strategies and drug resistance mechanisms in adenocarcinoma of different organs

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101002 - 101002

Published: Aug. 22, 2023

Adenocarcinoma is a common type of malignant tumor, originating from glandular epithelial cells in various organs, such as pancreas, breast, lung, stomach, colon, rectus, and prostate. For patients who lose the opportunity for radical surgery, medication available to provide potential clinical benefits. However, drug resistance big obstacle obtain desired prognosis. In this review, we summary treatment strategies mechanisms adenocarcinoma different including pancreatic cancer, gastric adenocarcinoma, colorectal lung prostate cancer. Although underlying molecular involved vary one organ other, there are several targets that universal targeting these molecules could potentially reverse adenocarcinomas.

Language: Английский

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FABP4 in macrophages facilitates obesity-associated pancreatic cancer progression via the NLRP3/IL-1β axis

Cancer Letters, Journal Year: 2023, Volume and Issue: 575, P. 216403 - 216403

Published: Sept. 21, 2023

Language: Английский

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Updated Clinical Evidence on the Role of Adipokines and Breast Cancer: A Review

Cancers, Journal Year: 2023, Volume and Issue: 15(5), P. 1572 - 1572

Published: March 3, 2023

With the recent leaps in medicine, landscape of our knowledge regarding adipose tissue has changed dramatically: it is now widely regarded as a fully functional endocrine organ. In addition, evidence from observational studies linked pathogenesis diseases like breast cancer with and mainly adipokines that are secreted its microenvironment, catalog continuously expanding. Examples include leptin, visfatin, resistin, osteopontin, more. This review aims to encapsulate current clinical concerning major their link oncogenesis. Overall, there have been numerous meta-analyses contribute evidence, however more targeted larger-scale still expected solidify utility BC prognosis reliability follow-up markers.

Language: Английский

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Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression

Cancer Letters, Journal Year: 2023, Volume and Issue: 569, P. 216306 - 216306

Published: July 11, 2023

Language: Английский

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