Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7226 - 7226
Published: June 30, 2024
Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.
Language: Английский
Citations
10
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 17, 2025
As breast cancer incidence continues to rise worldwide, there is a pressing need understand the environmental factors that contribute its development. Obesogens, including Bisphenol A (BPA) and Dichlorodiphenyltrichloroethane (DDT), are highly prevalent in environment, have been associated with obesity metabolic dysregulation. BPA DDT, known disrupt hormone signaling epithelial cells, also promote adipogenesis, lipogenesis, adipokine secretion adipose tissue, directly contributing pathogenesis of obesity. While adipose-rich mammary gland may be particularly vulnerable obesogens, scarcity research investigating obesogen-mediated changes adipocytes drive oncogenic transformation cells. Here, we review preclinical clinical evidence linking DDT impaired development risk. We discuss how obesogen-driven mechanisms obesity, secretion, could provide pro-inflammatory, nutrient-rich environment promotes activation pathways Understanding role obesogens risk progression essential for informing public health guidelines aimed at minimizing obesogen exposure, ultimately reduce improve outcomes women.
Language: Английский
Citations
1
Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3898 - 3898
Published: July 31, 2023
The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing levels of macro- micronutrients releasing hormones cytokines that recruit immune cells. Novel dietary interventions such as amino acid restriction periodic fasting mimicking diets can prevent or dampen formation acting systemically on release growth factors, inhibiting proinflammatory cytokines, remodeling vasculature extracellular matrix. Here, we discuss latest research effects these therapeutic immunometabolism response future scenarios pertaining to how could contribute therapy.
Language: Английский
Citations
19
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 199, P. 104389 - 104389
Published: May 10, 2024
Breast cancer (BC) is currently the most common malignant tumour in women and one of leading causes their death around world. New increasingly personalised diagnostic therapeutic tools have been introduced over last few decades, along with significant advances regarding study knowledge related to BC. The microenvironment (TME) refers cell-associated cellular molecular environment which can influence conditions affecting development progression. TME composed immune cells, stromal extracellular matrix (ECM) signalling molecules secreted by these different cell types. Ever deeper understanding composition changes during progression will enable new more innovative strategies become developed for targeting tumours specific stages its evolution. This review summarises role BC-related components on resistance therapy.
Language: Английский
Citations
7
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 14, 2024
Obesity has emerged as a prominent risk factor for the development of malignant tumors. However, existing literature on role adipocytes in tumor microenvironment (TME) to elucidate correlation between obesity and cancer remains insufficient. Here, we aim investigate formation cancer-associated (CAAs) their contribution growth using mouse models harboring dysfunctional adipocytes. Specifically, employ adipocyte-specific BECN1 KO (BaKO) mice, which exhibit lipodystrophy due Our results reveal activation YAP/TAZ signaling both CAAs BECN1-deficient adipocytes, inducing adipocyte dedifferentiation TME. The additional deletion from BaKO mice significantly restores inflammatory phenotypes, leading regression. Furthermore, fed high-fat diet (HFD) decreased increased expression adipose tissues. Treatment with inhibitor, verteporfin, suppresses progression HFD-fed highlighting its efficacy against metabolic dysregulation. Overall, our findings provide insights into key mediators CAA significance developing TME, thereby suggesting viable approach targeting homeostasis suppress growth.
Language: Английский
Citations
6
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112759 - 112759
Published: Aug. 3, 2024
Language: Английский
Citations
4
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 27, 2025
Abstract The role of epithelial membrane protein 1 (EMP1) in tumor microenvironment (TME) remodeling has not yet been elucidated. In addition, the biological function EMP1 triple-negative breast cancer (TNBC) is largely unclear. this study, we examined infiltration landscape cell types TME cancer, and found that expression was positively correlated with stromal microenvironmental scores. Infiltration analysis immunohistochemical (IHC) staining serial sections confirmed critical cancer-associated fibroblast (CAF) infiltration. Cell co-culture assays, xenograft experiments, loss-of-function, gain-of-function, RNA sequencing studies, rescue assays were performed to confirm CAF vitro vivo. These findings revealed depletion TNBC cells resulted considerable inhibition vivo vitro. Mechanistically, knockdown induced a substantial decrease IL6 secretion from through NF-κB signaling pathway, hindering proliferation subsequently inhibiting progression metastasis. cumulative results indicate functions as an oncogene by mediating communication CAFs. Targeted suppressing promising strategy for treatment.
Language: Английский
Citations
0
Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35200 - e35200
Published: July 26, 2024
Breast cancer has been reported to transcend lung as the most commonly diagnosed in women all over world. Adipocytes, serving energy storage and endocrine cells, are major stromal cells breast. Cancer-associated adipocytes (CAAs) adjacent dedifferentiated located at invasive front of human breast tumors. Adipocytes can transform into CAA phenotype with morphological biological changes under remodeling cells. CAAs play an essential role progression, including tumor microenvironment (TME), regulating immunity, interacting possess peculiar secretomes accordingly capable promote proliferation, invasiveness, angiogenesis, metastasis, immune escape, drug resistance There is a complex coordinated crosstalk among CAAs, release variety cytokines, IL-6, IL-8, IL-1β, CCL5, CCL2, VEGF, G-CSF, IGF-1, IGFBP, thereby promoting cell recruitment macrophage polarization, ultimately stimulating malignant behaviors Here, we aim provide comprehensive description CAA-derived their impact on behaviors, regulation, diagnosis, treatment. A deeper understanding performance interactions specific TME populations will better strategies for treatment reconstruction after mastectomy.
Language: Английский
Citations
3
Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 286 - 286
Published: Feb. 15, 2025
In the breast tumor microenvironment (TME), adipocytes exert a selective pressure on behavior of cancer stem cells (BCSCs), which are involved in endocrine therapy resistance. obesity, secrete reduced levels adiponectin, promotes growth and progression ERα-positive (BC). Here, we examined how low adiponectin affect enrichment BCSC subpopulation mechanisms contributing to maintenance resistance BC. Flow cytometry, qRT-PCR, Western blotting analysis were performed assess stemness, cell cycle, apoptosis markers MCF-7 wild-type (WT) tamoxifen-resistant (TR) mammospheres. nLC-MS/MS was employed profile compare proteome BCSCs. Differentially expressed proteins intersected with data from MetacoreTM dataset. Our study demonstrated that increased percentage CD44+/CD24-/ALDH1+ stem-like TR Specifically, contributed bulk through slow cycling rate, supported by decreased Cyclin D1 Ki67 p21 p27 expression, escape apoptosis, sustained ROS production preserved mitochondrial membrane potential. results provide new insights into contribution poor BC outcomes. Deeply understanding adiponectin's role stemness may disclose novel therapeutic approaches treat hormone-resistant obese patients.
Language: Английский
Citations
0