DNA and Cell Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Breast
cancer
(BC)
is
a
significant
contributor
to
cancer-related
deaths
in
women,
and
it
has
complex
connections
with
obesity
aging.
This
review
explores
the
interaction
between
aging
relation
development
progression
of
BC,
focusing
on
controlling
role
microRNAs
(miRNAs).
Obesity,
characterized
by
excess
adipose
tissue,
contributes
proinflammatory
environment
metabolic
dysregulation,
which
are
important
tumor
development.
Aging,
associated
cellular
senescence
systemic
changes,
further
exacerbates
these
conditions.
miRNAs,
small
noncoding
RNAs
that
regulate
gene
expression,
play
key
roles
processes,
impacting
pathways
involved
cell
proliferation,
apoptosis,
metastasis,
either
as
suppressors
or
oncogenes.
Importantly,
specific
miRNAs
implicated
mediating
impact
BC.
Exploring
regulatory
networks
controlled
provides
valuable
information
new
targets
for
therapy
predictive
markers,
demonstrating
potential
using
miRNA-based
interventions
treat
BC
obese
elderly
individuals.
emphasizes
importance
integrated
research
strategies
understand
obesity,
aging,
miRNA
regulation
American Journal of Cancer Research,
Journal Year:
2024,
Volume and Issue:
14(7), P. 3259 - 3279
Published: Jan. 1, 2024
The
tumor
microenvironment
(TME)
plays
a
critical
role
in
high
energy
metabolism
during
tumorigenesis,
progression
and
metastasis.
Among
them,
adipocytes,
as
an
important
component
of
the
TME,
can
transform
into
cancer-associated
adipocytes
(CAAs)
through
dedifferentiation
via
interactions
with
cells.
These
CAAs
provide
nutrients,
growth
factors,
cytokines
metabolites
to
later
transdifferentiate
other
stromal
cells
at
stage
alter
growth,
metastasis
drug
response
ultimately
influence
treatment
prognosis
ovarian
cancer.
This
review
outlines
physiological
functions
discusses
progress
use
therapeutic
targets
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11735 - 11735
Published: Oct. 31, 2024
Gastric
cancer
(GC)
is
one
of
the
most
common
cancers
worldwide.
Most
patients
are
diagnosed
at
progressive
stage
GC,
and
progress
in
development
effective
anti-GC
drugs
has
been
insufficient.
The
tumor
microenvironment
(TME)
regulates
various
functions
cells,
interactions
between
cellular
molecular
components
TME-e.g.,
inflammatory
fibroblasts,
vasculature
innate
adaptive
immune
cells-promote
aggressiveness
cells
dissemination
to
distant
organs.
This
review
summarizes
roles
TME
molecules
regulating
malignant
progression
metastasis
GC.
We
also
address
important
signaling
pathways
mediating
interaction
different
GC
TME.
Finally,
we
discuss
implications
these
mechanisms
for
developing
novel
therapies
targeting
control
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(10), P. 6093 - 6093
Published: May 17, 2022
Insulin
levels,
adipocytokines,
and
inflammatory
mediators
trigger
benign
breast
disease
(BBD)
cancer
(BC).
The
relationship
between
serum
adipocytokines
overweight-obesity,
metabolic
disturbs,
BC
is
unclear.
Methods:
To
analyze
the
levels
of
insulin,
HOMA
IR
in
women
without
disease,
with
BBD
or
BC,
role
these
as
risk
factors
for
cancer.
Results:
Adipsin
values
>
0.91
visfatin
1.18
ng/mL
represent
a
factor
to
develop
NBD
lean
(OR
=
18;
OR
12).
Data
overweight-obese
groups
confirm
observation
due
insulin
2.6
mU/mL
0.78,
60.2
18,
respectively;
adipsin
26.4,
12.
Breast
showed
similar
behavior:
risk,
adjusted
by
56
22.7.
Conclusion:
Adipose
tissue
crucial
premalignant
malignant
transformation
overweight-obesity.
adipocyte−breast
epithelium
interaction
could
continuum,
starting
especially
women.
DNA and Cell Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Breast
cancer
(BC)
is
a
significant
contributor
to
cancer-related
deaths
in
women,
and
it
has
complex
connections
with
obesity
aging.
This
review
explores
the
interaction
between
aging
relation
development
progression
of
BC,
focusing
on
controlling
role
microRNAs
(miRNAs).
Obesity,
characterized
by
excess
adipose
tissue,
contributes
proinflammatory
environment
metabolic
dysregulation,
which
are
important
tumor
development.
Aging,
associated
cellular
senescence
systemic
changes,
further
exacerbates
these
conditions.
miRNAs,
small
noncoding
RNAs
that
regulate
gene
expression,
play
key
roles
processes,
impacting
pathways
involved
cell
proliferation,
apoptosis,
metastasis,
either
as
suppressors
or
oncogenes.
Importantly,
specific
miRNAs
implicated
mediating
impact
BC.
Exploring
regulatory
networks
controlled
provides
valuable
information
new
targets
for
therapy
predictive
markers,
demonstrating
potential
using
miRNA-based
interventions
treat
BC
obese
elderly
individuals.
emphasizes
importance
integrated
research
strategies
understand
obesity,
aging,
miRNA
regulation
