Experimental Hematology and Oncology,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Nov. 1, 2024
Developing
resistance
to
cancer
treatments
is
a
major
challenge,
often
leading
disease
recurrence
and
metastasis.
Understanding
the
underlying
mechanisms
of
therapeutic
critical
for
developing
effective
strategies.
O-GlcNAcylation,
post-translational
modification
that
adds
GlcNAc
from
donor
UDP-GlcNAc
serine
threonine
residues
proteins,
plays
crucial
role
in
regulating
protein
function
cellular
signaling,
which
are
frequently
dysregulated
cancer.
Similarly,
ubiquitination,
involves
attachment
ubiquitin
degradation,
cell
cycle
control,
DNA
repair.
The
interplay
between
O-GlcNAcylation
ubiquitination
associated
with
progression
treatment.
This
review
discusses
recent
discoveries
regarding
roles
resistance,
their
interactions,
potential
mechanisms.
It
also
explores
how
targeting
these
pathways
may
provide
new
opportunities
overcome
treatment
cancer,
offering
fresh
insights
directions
research
development.
Molecular Medicine Reports,
Journal Year:
2024,
Volume and Issue:
30(2)
Published: June 18, 2024
The
TGF‑β/Smad
signaling
pathway
plays
a
pivotal
role
in
the
onset
of
glomerular
and
tubulointerstitial
fibrosis
chronic
kidney
disease
(CKD).
present
review
delves
into
intricate
post‑translational
modulation
this
its
implications
CKD.
Specifically,
impact
on
various
biological
processes
was
investigated,
encompassing
not
only
renal
tubular
epithelial
cell
apoptosis,
inflammation,
myofibroblast
activation
cellular
aging,
but
also
autophagy.
Various
modifications
(PTMs),
including
phosphorylation
ubiquitination,
play
crucial
modulating
intensity
persistence
pathway.
They
dictate
functionality,
stability
interactions
components.
sheds
light
recent
findings
regarding
PTMs
TGF‑β
receptors
Smads
within
CKD
landscape.
In
summary,
deeper
insight
intricacies
offers
avenues
for
innovative
therapeutic
interventions
to
mitigate
progression.
Ongoing
research
domain
holds
potential
unveil
powerful
antifibrotic
treatments,
aiming
preserve
integrity
function
patients
with
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 4, 2024
Immunotherapy
has
been
developed,
which
harnesses
and
enhances
the
innate
powers
of
immune
system
to
fight
disease,
particularly
cancer.
PD-1
(programmed
death-1)
PD-L1
death
ligand-1)
are
key
components
in
regulation
system,
context
cancer
immunotherapy.
regulated
by
PTMs,
including
phosphorylation,
ubiquitination,
deubiquitination,
acetylation,
palmitoylation
glycosylation.
PROTACs
(Proteolysis
Targeting
Chimeras)
a
type
new
drug
design
technology.
They
specifically
engineered
molecules
that
target
specific
proteins
within
cell
for
degradation.
have
designed
demonstrated
their
inhibitory
activity
against
PD-1/PD-L1
pathway,
showed
ability
degrade
proteins.
In
this
review,
we
describe
how
improve
efficacy
could
be
novel
strategy
combine
with
radiotherapy,
chemotherapy
immunotherapy
patients.
Journal of Biological Chemistry,
Journal Year:
2024,
Volume and Issue:
300(9), P. 107709 - 107709
Published: Aug. 22, 2024
O-linked
N-acetylglucosaminylation
(O-GlcNAcylation)
is
a
dynamic
and
reversible
posttranslational
modification
that
targets
serine
threonine
residues
in
variety
of
proteins.
Uridine
diphospho-N-acetylglucosamine,
which
synthesized
from
glucose
via
the
hexosamine
biosynthesis
pathway,
major
donor
this
modification.
O-GlcNAc
transferase
sole
enzyme
transfers
GlcNAc
onto
protein
substrates,
while
O-GlcNAcase
responsible
for
removing
O-GlcNAcylation
plays
an
important
role
tumorigenesis
progression
through
specific
substrates.
In
review,
we
discuss
tumor-related
biological
functions
summarize
recent
progress
development
pharmaceutical
options
to
manipulate
proteins
as
potential
anticancer
therapies.
Frontiers in Physiology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 10, 2024
O-GlcNAcylation,
as
a
post-translational
modification,
can
modulate
cellular
activities
such
kinase
activity,
transcription-translation,
protein
degradation,
and
insulin
signaling
by
affecting
the
function
of
substrate,
including
localization
proteins,
stability,
protein/protein
interactions.
Accumulating
evidence
suggests
that
dysregulation
O-GlcNAcylation
is
associated
with
disease
progression
cancer,
neurodegeneration,
diabetes.
Recent
studies
suggest
also
involved
in
regulation
osteoblast,
osteoclast
chondrocyte
differentiation,
which
closely
related
to
initiation
development
bone
metabolic
diseases
osteoporosis,
arthritis
osteosarcoma.
However,
potential
mechanisms
regulates
metabolism
are
not
fully
understood.
In
this
paper,
literature
was
summarized
provide
new
therapeutic
strategies
for
treatment
orthopedic
osteoporosis.
