Single-cell transcriptomic analysis reveals the landscape of epithelial-mesenchymal transition molecular heterogeneity in esophageal squamous cell carcinoma

Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216723 - 216723

Published: Feb. 10, 2024

Language: Английский

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Exploring the biological mechanism and clinical value of perineural invasion in pancreatic cancer

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217515 - 217515

Published: Jan. 1, 2025

Language: Английский

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Biological characteristics of pancreatic ductal adenocarcinoma: Initiation to malignancy, intracellular to extracellular

Cancer Letters, Journal Year: 2023, Volume and Issue: 574, P. 216391 - 216391

Published: Sept. 15, 2023

Language: Английский

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Biodistribution and therapeutic efficacy of a gold nanoparticle-based targeted drug delivery system against pancreatic cancer

Cancer Letters, Journal Year: 2024, Volume and Issue: 589, P. 216810 - 216810

Published: March 15, 2024

Language: Английский

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Frontiers in pancreatic cancer on biomarkers, microenvironment, and immunotherapy

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217350 - 217350

Published: Nov. 1, 2024

Pancreatic cancer remains one of the most challenging malignancies to treat due its late-stage diagnosis, aggressive progression, and high resistance existing therapies. This review examines latest advancements in early detection, therapeutic strategies, with a focus on emerging biomarkers, tumor microenvironment (TME) modulation, integration artificial intelligence (AI) data analysis. We highlight promising including microRNAs (miRNAs) circulating DNA (ctDNA), that offer enhanced sensitivity specificity for early-stage diagnosis when combined multi-omics panels. A detailed analysis TME reveals how components such as cancer-associated fibroblasts (CAFs), immune cells, extracellular matrix (ECM) contribute therapy by creating immunosuppressive barriers. also discuss interventions target these components, aiming improve drug delivery overcome evasion. Furthermore, AI-driven analyses are explored their potential interpret complex data, enabling personalized treatment strategies real-time monitoring response. conclude identifying key areas future research, clinical validation regulatory frameworks AI applications, equitable access innovative comprehensive approach underscores need integrated, outcomes pancreatic cancer.

Language: Английский

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Breaking the stromal barrier in pancreatic cancer: Advances and challenges

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1879(1), P. 189065 - 189065

Published: Dec. 30, 2023

Language: Английский

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The New Era of Pancreatic Cancer Treatment: Application of Nanotechnology Breaking Through Bottlenecks

Cancer Letters, Journal Year: 2024, Volume and Issue: 594, P. 216979 - 216979

Published: May 23, 2024

Language: Английский

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SIRT7 knockdown promotes gemcitabine sensitivity of pancreatic cancer cell via upregulation of GLUT3 expression

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217109 - 217109

Published: July 14, 2024

Language: Английский

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Macroautophagy/autophagy promotes resistance to KRASG12D-targeted therapy through glutathione synthesis

Cancer Letters, Journal Year: 2024, Volume and Issue: 604, P. 217258 - 217258

Published: Sept. 13, 2024

Language: Английский

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The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216769 - 216769

Published: March 2, 2024

Language: Английский

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