Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586

Published: Dec. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Language: Английский

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Drug delivery using gold nanoparticles

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 216, P. 115481 - 115481

Published: Nov. 29, 2024

Language: Английский

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Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC)

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.

Language: Английский

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Cascade Ultrasonic Cavitation Enables Microbubble–Nanoparticle Hybrid to Broadly Accumulate and Penetrate into Pancreatic Ductal Adenocarcinoma

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

To address the challenges of limited drug accumulation and penetration in pancreatic ductal adenocarcinoma (PDAC), a cascade ultrasonic cavitation strategy designed to enhance delivery by sequentially overcoming biological barriers is developed. This approach employs macrophage membrane‐modified microbubble–nanoparticle hybrid (MMB@TFHPD) capable cavitation. MMB@TFHPD consists microbubble coating (MMB) mesoporous silica core (TFHPD), coloaded with doxorubicin perfluoropentane. Following intravenous administration, accumulates near tumor endothelial cells via ligand–receptor interaction. Low‐intensity ultrasound (first US) then applied induce primary cavitation, disrupting blood‐tumor barrier enhancing TFHPD NPs accumulate within periphery. Upon exposure acidic microenvironment (TME), surface tannic acid–iron complexes (TA/Fe 3+ ) degrade, exposing structure. High‐intensity US (second subsequently applied, triggering liquid‐to‐gas phase transition PFP microbubbles destruction, which induces extracellular matrix collapse, rapid release, deep into parenchyma. process results potent antitumor effects PDAC therapy. In summary, this study introduces promising overcome key for other solid tumors.

Language: Английский

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Functional gold nanoparticles in diagnosis and treatment of cancer: A systematic review

APL Materials, Journal Year: 2025, Volume and Issue: 13(5)

Published: May 1, 2025

Early diagnosis and prompt treatment of cancer are critical to reducing mortality rates enhancing patient quality life. Nanotechnology-driven emerging approaches widely adopted in early treatment, effectively addressing the high costs, potential radiation risks, sensitivity limitations traditional methods. Among diverse range nanomaterials, gold nanoparticles (Au NPs) have demonstrated remarkable for owing their exceptional physicochemical stability distinctive localized surface plasmon resonance effect. Moreover, small size enables Au NPs target malignant tumor tissues passively through enhanced permeation retention This review begins with a concise overview optical properties NPs, followed by an examination detection mechanism NP-based biosensors markers systematic summary related studies. The latest advances NPs-based therapeutic technology research, including photothermal therapy, photodynamic combination therapy field highlighted. Finally, this provides outlook further applications diagnostic integration.

Language: Английский

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New Nanoparticle-Based Drug: A 2024 Update and Future Prospects

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(3)

Published: May 19, 2025

Language: Английский

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Nanocarrier Design Based on the Tumor Microenvironment Target: A Pivotal Direction in Nano-Drug Delivery Strategies

Diseases & Research, Journal Year: 2024, Volume and Issue: 4(0), P. 1 - 8

Published: Jan. 1, 2024

Language: Английский

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Biomaterials and Nanomedicines: Progress in Cancer Research

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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