International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13722 - 13722
Published: Dec. 23, 2024
As
the
primary
glial
cells
in
peripheral
nervous
system
(PNS),
Schwann
(SCs)
have
been
proven
to
influence
behavior
of
cancer
profoundly
and
are
involved
progression
through
extensive
interactions
with
other
stromal
cells.
Indeed,
tumor
microenvironment
(TME)
is
a
critical
factor
that
can
significantly
limit
efficacy
immunotherapeutic
approaches.
The
TME
promotes
part
by
reshaping
an
immunosuppressive
state.
result
crosstalk
between
different
immune
cell
subsets,
including
macrophages,
natural
killer
(NK)
cells,
dendritic
(DCs),
lymphocytes,
myeloid-derived
suppressor
(MDSCs),
etc.
They
closely
related
anti-tumor
status
clinical
prognosis
patients.
Increasing
research
demonstrates
SCs
these
reshape
formation
via
secretion
various
cytokines,
chemokines,
effector
molecules,
eventually
facilitating
evasion
progression.
In
this
review,
we
summarize
SC
reprogramming
TME,
emerging
role
microenvironment,
underlying
mechanisms
involved.
We
also
discuss
possible
therapeutic
strategies
selectively
target
SCs,
providing
insights
perspectives
for
future
studies
involving
SC-targeted
treatment.
Briefings in Bioinformatics,
Journal Year:
2025,
Volume and Issue:
26(2)
Published: March 1, 2025
Cancer
cells
acquire
necessary
functional
capabilities
for
malignancy
through
the
influence
of
nervous
system.
We
evaluate
extent
neural
infiltration
within
tumor
microenvironment
(TME)
across
multiple
cancer
types,
highlighting
its
role
as
a
hallmark.
identify
cancer-related
genes
using
40
bulk
RNA-seq
datasets
10
developing
predictive
score
(C-Neural
score).
samples
with
elevated
C-Neural
scores
exhibit
perineural
invasion,
recurrence,
metastasis,
higher
stage
or
grade,
poor
prognosis.
Epithelial
show
highest
among
all
cell
types
in
55
single-cell
RNA
sequencing
datasets.
The
epithelial
high
(epi-highCNs)
characterized
by
increased
copy
number
variation,
reduced
differentiation,
epithelial-mesenchymal
transition
scores,
and
metabolic
level.
Epi-highCNs
frequently
communicate
Schwann
FN1
signaling
pathway.
co-culture
experiment
indicates
that
may
facilitate
progression
upregulation
VDAC1.
Moreover,
positively
correlate
antitumor
immune
cells,
indicating
potential
response
immunotherapy.
Melanoma
patients
benefit
from
trametinib.
These
analyses
illuminate
TME,
suggesting
hallmark
offering
implications
effective
therapeutic
strategies
against
cancer.
