The effect of non-pharmacological interventions on cognitive function in cancer: an overview of systematic reviews

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(2)

Published: Feb. 1, 2025

Abstract Purpose A significant number of cancer survivors experience cancer-related cognitive impairment (CRCI), which can impact their ability to think, reason, make decisions, and perform daily actions. In recent years, non-pharmacological interventions for CRCI have gained attention. These include exercise, behavioural therapy, training/remediation, dietary, mind–body, multi-modal/complex interventions. This umbrella review provides a critical overview inform guidelines current practice, identify the most promising interventions, uncover gaps in research literature. Methods systematic reviews was pre-registered on Open Science Framework PROSPERO. Six databases were searched. Systematic (SR) assessing any improve cognition (any type) included. The followed gold-standard recommendations. results narratively synthesised, descriptive statistics effect size ranges calculated. Results Sixty-four ( n = 64) SRs synthesised into four domains. Cognitive training/rehabilitation had strongest evidence efficacy. Physical activity/exercise showed efficacy; however, variability findings considerable. Mind–body psychological/behavioural therapy limited, but there short-term effectiveness. Multi-modal/complex potential improving poorly defined. Conclusions Overall, demonstrated efficacy cancer. There limited intervention characteristics within domains consistently related Three key recommendations are provided future research: (1) adopt harmonisation reporting guidelines; (2) develop definitional research; (3) assess participant associated with positive versus null/negative findings.

Language: Английский

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The MASCC COG-IMPACT: An unmet needs assessment for cancer-related cognitive impairment impact developed by the Multinational Association of Supportive Care in Cancer

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(2)

Published: Jan. 24, 2025

Abstract Purpose Cancer-related cognitive impairment (CRCI) can have a profound impact on the lives of cancer survivors. A multitude subjective and objective assessment tools exist to assess presence severity CRCI. However, no purpose-built tool exists unmet needs survivors directly relating This paper details development initial validation Multinational Association Supportive Care in Cancer - Unmet Needs Assessment Cancer-Related Cognitive Impairment Impact (the MASCC COG-IMPACT). Methods multistep mixed-methods measurement approach was taken with strong emphasis co-design. Qualitative interviews were conducted ( n = 32) oncology health professionals 19), followed by modified Delphi survey 29). 22) over two rounds then finalise penultimate version for Four-hundred ninety-one 491) completed COG-IMPACT other established measures inform structural, reliability, validity, acceptability, appropriateness, feasibility analyses. Results The final is 55-item eight subscale including indices: “difficulties” “unmet needs”. found structural convergent discriminant internal consistency, test–retest reliability. also be highly acceptable, appropriate, feasible. Conclusion may facilitate optimal care referral line survivor’s CRCI-related difficulties needs. used explore factors contributors Overall, reliable valid both clinical research settings. supporting materials accessed webpage or via Open Science Framework https://osf.io/5zc3a/ ).

Language: Английский

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Reconceptualizing mental health in cancer survivorship

Trends in cancer, Journal Year: 2024, Volume and Issue: 10(8), P. 677 - 686

Published: June 18, 2024

Language: Английский

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Cancer-related cognitive impairment as a key contributor to psychopathology in cancer survivors: implications for prevention, treatment and supportive care

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(7)

Published: July 1, 2024

Abstract A significant proportion of cancer survivors will experience some form mental health compromise across domains including mood, anxiety, psychosis, eating disorders, and substance use. This psychopathology within is related to a range negative outcomes can also have substantial impact on quality life. Along with psychopathology, cognitive impairments are commonly experienced, resulting in deficits memory, reasoning, decision-making, speed processing, concentration, collectively referred as cancer-related impairment (CRCI). Within the non-oncology literature, consistently demonstrated be key transdiagnostic aetiological feature functionally contributing development perpetuation symptoms. Whilst there an acknowledgement role concerns might play perception CRCI, has been limited research exploring potential for CRCI contribute toward beyond simply psychosocial distress. Given theoretical empirical evidence suggesting factor we provide rationale survivors. functional association implications risk identification, prevention, treatment, supportive care approaches regarding survivorship. We conclude by providing directions future this area.

Language: Английский

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It’s about time: mitigating cancer-related cognitive impairments through findings from computational models of the Wisconsin Card Sorting Task

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 4, 2024

Abstract Background Many cancer survivors experience cancer-related cognitive impairment (CRCI), often with significant negative consequences across various life domains. Emerging evidence suggests that allowing additional time to process information before acting may be a useful strategy for those CRCI mitigate some of its impacts. The Wisconsin Card Sorting Task (WCST), measure general cognition, has shown survivors, longer task completion facilitates similar performance outcomes control populations concerning perseveration errors; key metric the WCST. However, assessing if this useful, as well determining whom it regard strengths and weaknesses among select domains, is challenging due factors such problem impurity. Accordingly, study provides an initial computational experimental assessment whether CRCI. Methods We simulated individual differences observed in humans by varying contributions executive functioning components (updating, shifting, inhibition) yield 48 distinct models Our main manipulation was then provide these more or less (at three levels 20, 40 60 cycles) executed action sort given card. compared number errors on WCST produced models. Additionally, we determined comparing human data. Results Additional processing resulted producing significantly fewer errors, supporting our hypothesis. In addition, 8 unique appeared have positive influence primarily mitigating impacts severe inhibition impairments. For global function impairments, substantial amount required most unable adequately impact performance. Conclusion rectify findings implications development practical strategies, workload deadline management occupational settings, which effects

Language: Английский

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Protocol for the Development and Initial Validation of the COG-IMPACT Tool: A Purpose-Built Unmet Needs Assessment for Cancer-Related Cognitive Impairment

Methods and Protocols, Journal Year: 2024, Volume and Issue: 7(4), P. 54 - 54

Published: July 10, 2024

(1)

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Accounting for unmet needs resulting from cancer-related cognitive impairment

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Purpose Cancer-related cognitive impairment (CRCI) causes a wide range of unmet needs for cancer survivors. It is unknown which clinical, demographic, cognitive, and psychological factors underpin account these various needs. This study aimed to ( ) identify associated with CRCI-related needs, b establish the most pertinent that Methods Four hundred fifty-six n = 456) survivors responded demographic clinical questions, as well measures (MASCC COG-IMPACT), perceived (PROMIS-COG), distress (DASS-21). Descriptive statistics, bivariate correlations, feed-forward multiple regression analyses were completed. Results Cognitive severity r 0.39 0.59; p < 0.01), 0.36 0.58; time since diagnosis − 0.11 0.20; 0.05 0.02) significantly across all domains. Age 0.10 0.22; 0.001 0.03), stage at initial 0.13; 0.04), progressed 0.18; sex 0.12; 0.01; females experiencing greater than males), one or more domains need. accounting R 2 0.245, F (3, 487) 48.96, 0.474, 114.81, 0.001), explaining 24.5% 47.4% variance. Conclusion key in Other variables, while did not provide additional predictive utility. Implications Cancer Survivors The results may inform choice supportive care targets, future strategies, improve people cancer-related impairment.

Language: Английский

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Effectiveness of Non-Pharmacological Interventions to Improve Cognition in Cancer: A Protocol For An Overview Of Systematic Reviews

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Abstract Many cancer survivors, including those with a current or previous diagnosis of cancer, experience cancer-related cognitive impairments (CRCI). CRCI can impact their ability to think quickly, clearly, make decisions and perform daily actions. There have been variety non-pharmacological interventions developed trialed the aim reducing mitigating its impact. The this work is provide an overall picture effectiveness improve cognition in survivors by providing overview synthesis systematic reviews. Review Title Effectiveness Non-Pharmacological Interventions Improve Cognition Cancer: An Overview Systematic Reviews

Language: Английский

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Avoiding the pitfalls of the DSM-5: A primer for health professionals

General Hospital Psychiatry, Journal Year: 2024, Volume and Issue: 90, P. 88 - 90

Published: July 20, 2024

Language: Английский

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Application of Artificial Intelligence in Symptom Monitoring in Adult Cancer Survivorship: A Systematic Review

JCO Clinical Cancer Informatics, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 1, 2024

PURPOSE The adoption of artificial intelligence (AI) in health care may afford new avenues for personalized and patient-centered care. This systematic review explored the role AI symptom monitoring adult cancer survivors. METHODS A comprehensive search was performed from inception to November 2023 seven bibliographic databases three clinical trial registries. PROSPERO registered (ID: CRD42023476027) assessed reports empirical research studies use (physical psychological symptoms) across all types adults. RESULTS total 18,530 were identified, which 41 met criteria analyzed. Included predominantly published between 2021 2023, originated United States (39.0%) Japan (14.6%), primarily used cohort designs (80.5%), followed by cross-sectional (12.2%). mean sample size 617.14 (standard deviation = 1,401.37), with most including multiple tumor (31.7%) or breast survivors (26.8%). Machine learning algorithms (43.9%) method, natural language processing (29.3%), AI-driven chatbots (17.1%), decision support tools (9.8%). common inputs textual data, patient-reported symptoms, physiologic measurements. examined pain (34.2% studies), fatigue nausea (17.1% each). Overall, showed increasing technology prediction symptoms. CONCLUSION is being enhance various settings. When considering integration into practice, standardization data capture, analytics, investing infrastructure, end-user experience should be considered successful implementation improvement patient outcomes.

Language: Английский

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