Molecular Genetics and Metabolism, Journal Year: 2024, Volume and Issue: 143(1-2), P. 108540 - 108540
Published: July 17, 2024
Language: Английский
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 5, 2024
The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting normal cell survival. As tumors progress, gradually becomes place promote progression. Immune have attracted much attention as targets immunotherapy. checkpoint inhibitor (ICI) therapy has potential regulate TME, suppressing factors that facilitate advancement, reactivating immune managing growth, extending advanced cancer. This review presents an outline current studies on distinct cellular elements within detailing their main functions possible signaling pathways. Additionally, we examine immunotherapy rechallenge OC, specific emphasis biological reasons behind resistance ICIs.
Language: Английский
Citations
3
Immunology, Journal Year: 2024, Volume and Issue: 173(1), P. 53 - 75
Published: June 12, 2024
The cross-regulation of immunity and metabolism is currently a research hotspot in life sciences immunology. Metabolic immunology plays an important role cutting-edge fields such as metabolic regulatory mechanisms immune cell development function, targets immune-related disease pathways. Protein post-translational modification (PTM) key epigenetic mechanism that regulates various biological processes highlights metabolite functions. Currently, more than 400 PTM types have been identified to affect the functions several proteins. Among these, PTMs, particularly newly histone or non-histone acylation modifications, can effectively regulate functions, diseases system, well diseases. Thus, drugs aimed at targeted substantial therapeutic potential regulating immunity, indicating new direction for further clinical translational research. This review summarises characteristics seven novel lysine including succinylation, S-palmitoylation, lactylation, crotonylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation malonylation, their association with thereby providing valuable references diagnosis treatment disorders associated modifications.
Language: Английский
Citations
3
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(37), P. 9111 - 9143
Published: Jan. 1, 2024
The unique roles of nanozymes in enhancing immunotherapy through disrupting tumor metabolism and mediating combination therapies.
Language: Английский
Citations
2
Molecular Genetics and Metabolism, Journal Year: 2024, Volume and Issue: 143(1-2), P. 108540 - 108540
Published: July 17, 2024
Language: Английский
Citations
1