Aesthetic Surgery Journal,
Journal Year:
2023,
Volume and Issue:
43(10), P. 1063 - 1090
Published: Aug. 28, 2023
Abstract
For
decades,
a
wide
variety
of
natural
and
synthetic
materials
have
been
used
to
augment
human
tissue
improve
aesthetic
outcomes.
Dermal
fillers
are
some
the
most
widely
treatments
throughout
body.
Initially,
primary
function
dermal
was
restore
depleted
volume.
As
biomaterial
research
has
advanced,
however,
biostimulatory
become
staples
in
medicine.
Such
often
contain
carrying
vehicle
material
that
induces
de
novo
synthesis
major
structural
components
extracellular
matrix.
One
such
filler,
Radiesse
(Merz
Aesthetics,
Raleigh,
NC),
is
composed
calcium
hydroxylapatite
microspheres
suspended
carboxymethylcellulose
gel.
In
addition
immediate
volumization,
treatment
results
increases
collagen,
elastin,
vasculature,
proteoglycans,
fibroblast
populations
via
cell-biomaterial–mediated
interaction.
When
injected,
acts
as
cell
scaffold
clinically
manifests
restoration
volume,
improvements
skin
quality
appearance,
regeneration
endogenous
matrices.
This
narrative
review
contextualizes
regenerative
treatment,
summarizes
its
unique
use
cases,
reviews
rheological,
material,
properties,
hypothesizes
future
combination
age
aesthetics.
Level
Evidence:
5
Pharmaceuticals,
Journal Year:
2021,
Volume and Issue:
14(12), P. 1215 - 1215
Published: Nov. 24, 2021
Presently,
notwithstanding
the
progress
regarding
wound-healing
management,
treatment
of
majority
skin
lesions
still
represents
a
serious
challenge
for
biomedical
and
pharmaceutical
industries.
Thus,
attention
researchers
has
turned
to
development
novel
materials
based
on
cellulose
derivatives.
Cellulose
derivatives
are
semi-synthetic
biopolymers,
which
exhibit
high
solubility
in
water
represent
an
advantageous
alternative
water-insoluble
cellulose.
These
biopolymers
possess
excellent
properties,
such
as
biocompatibility,
biodegradability,
sustainability,
non-toxicity,
non-immunogenicity,
thermo-gelling
behavior,
mechanical
strength,
abundance,
low
costs,
antibacterial
effect,
hydrophilicity.
They
have
efficient
ability
absorb
retain
large
quantity
wound
exudates
interstitial
sites
their
networks
can
maintain
optimal
local
moisture.
also
proper
scaffold
incorporate
various
bioactive
agents
with
beneficial
therapeutic
effects
tissue
restoration.
Due
these
suitable
versatile
characteristics,
attractive
captivating
applications.
This
review
presents
extensive
overview
recent
research
promising
derivatives-based
multiple
applications,
dressings,
drug
delivery
devices,
engineering.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(12), P. 6564 - 6564
Published: June 12, 2022
Three-dimensional
(3D)
bioprinting
is
an
innovative
technology
in
the
biomedical
field,
allowing
fabrication
of
living
constructs
through
approach
layer-by-layer
deposition
cell-laden
inks,
so-called
bioinks.
An
ideal
bioink
should
possess
proper
mechanical,
rheological,
chemical,
and
biological
characteristics
to
ensure
high
cell
viability
production
tissue
with
dimensional
stability
shape
fidelity.
Among
several
types
bioinks,
hydrogels
are
extremely
appealing
as
they
have
many
similarities
extracellular
matrix,
providing
a
highly
hydrated
environment
for
proliferation
tunability
terms
mechanical
rheological
properties.
Hydrogels
derived
from
natural
polymers,
polysaccharides,
particular,
excellent
platform
mimic
given
their
low
cytotoxicity,
hydrophilicity,
diversity
structures.
In
fact,
polysaccharide-based
trendy
materials
3D
since
abundant
combine
adequate
physicochemical
biomimetic
features
development
novel
Thus,
this
review
portrays
most
relevant
advances
hydrogel
bioinks
bioprinting,
focusing
on
last
five
years,
emphasis
properties,
advantages,
limitations,
considering
polysaccharide
families
classified
according
source,
namely
seaweed,
higher
plants,
microbial,
animal
(particularly
crustaceans)
origin.
International Journal of Biological Macromolecules,
Journal Year:
2023,
Volume and Issue:
251, P. 126287 - 126287
Published: Aug. 11, 2023
Cellulose
nanocrystals
(CNCs)
have
gained
significant
attraction
from
both
industrial
and
academic
sectors,
thanks
to
their
biodegradability,
non-toxicity,
renewability
with
remarkable
mechanical
characteristics.
Desirable
characteristics
of
CNCs
include
high
stiffness,
strength,
excellent
flexibility,
large
surface-to-volume
ratio.
Additionally,
the
properties
can
be
tailored
through
chemical
modifications
for
high-end
applications
including
tissue
engineering,
actuating,
biomedical.
Modern
manufacturing
methods
3D/4D
printing
are
highly
advantageous
developing
sophisticated
intricate
geometries.
This
review
highlights
major
developments
additive
manufactured
CNCs,
which
promote
sustainable
solutions
across
a
wide
range
applications.
this
contribution
also
presents
current
challenges
future
research
directions
CNC-based
composites
developed
techniques
myriad
engineering
sectors
wound
healing,
wearable
electronics,
robotics,
anti-counterfeiting
Overall,
will
greatly
help
scientists
chemistry,
materials,
biomedicine,
other
disciplines
comprehend
underlying
principles,
properties,
additively
structures.
Gels,
Journal Year:
2024,
Volume and Issue:
10(4), P. 216 - 216
Published: March 22, 2024
Hydrogels,
being
hydrophilic
polymer
networks
capable
of
absorbing
and
retaining
aqueous
fluids,
hold
significant
promise
in
biomedical
applications
owing
to
their
high
water
content,
permeability,
structural
similarity
the
extracellular
matrix.
Recent
chemical
advancements
have
bolstered
versatility,
facilitating
integration
molecules
guiding
cellular
activities
enabling
controlled
activation
under
time
constraints.
However,
conventional
synthetic
hydrogels
suffer
from
inherent
weaknesses
such
as
heterogeneity
network
imperfections,
which
adversely
affect
mechanical
properties,
diffusion
rates,
biological
activity.
In
response
these
challenges,
hybrid
emerged,
aiming
enhance
strength,
drug
release
efficiency,
therapeutic
effectiveness.
These
hydrogels,
featuring
improved
formulations,
are
tailored
for
tissue
regeneration
across
both
soft
hard
tissues.
The
scientific
community
has
increasingly
recognized
versatile
characteristics
particularly
sector.
This
comprehensive
review
delves
into
recent
hydrogel
systems,
covering
diverse
types,
modification
strategies,
nano/microstructures.
discussion
includes
innovative
fabrication
techniques
click
reactions,
3D
printing,
photopatterning
alongside
elucidation
mechanisms
bioactive
molecules.
By
addressing
underscores
envisages
a
promising
future
various
domains
field.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2156 - 2221
Published: March 20, 2024
Tissue
engineering
for
injured
tissue
replacement
and
regeneration
has
been
a
subject
of
investigation
over
the
last
30
years,
there
considerable
interest
in
using
additive
manufacturing
to
achieve
these
goals.
Despite
such
efforts,
many
key
questions
remain
unanswered,
particularly
area
biomaterial
selection
applications
as
well
quantitative
understanding
process
science.
The
strategic
utilization
biological
macromolecules
provides
versatile
approach
meet
diverse
requirements
3D
printing,
printability,
buildability,
biocompatibility.
These
molecules
play
pivotal
role
both
physical
chemical
cross-linking
processes
throughout
biofabrication,
contributing
significantly
overall
success
printing
process.
Among
several
bioprintable
materials,
gelatin
methacryloyl
(GelMA)
widely
utilized
applications,
with
some
degree
success.
In
this
context,
review
will
discuss
bioengineering
approaches
identify
gelation
strategies
that
are
appropriate
control
rheology,
buildability
inks.
This
focus
on
GelMA
structural
(scaffold)
different
tissues
potential
carrier
vehicle
transport
living
cells
their
maintenance
viability
physiological
system.
Recognizing
importance
printability
toward
shape
fidelity
biophysical
properties,
major
qualitative
impact
factors,
including
microrheological,
viscoelastic,
gelation,
shear
thinning
properties
inks,
parameters,
particular,
reference
extrusion
GelMA-based
Specifically,
we
emphasize
possibilities
regulate
mechanical,
swelling,
biodegradation,
cellular
functionalities
bio(material)
by
hybridization
techniques,
synthetic
natural
biopolymers,
inorganic
nanofillers,
microcarriers.
At
close,
possibility
integration
experimental
data
sets
artificial
intelligence/machine
learning
is
emphasized
predict
fidelity,
or
inks
clinically
relevant
tissues.
