Analytica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
1318, P. 342948 - 342948
Published: July 6, 2024
Cyclodextrins
are
a
well-established
system
which
form
inclusion
complexes
with
many
guest
molecules.
This
property
can
be
easily
exploited
to
develop
drug
delivery
systems.
Additionally,
carbon
dots
(CD)
low-toxic
photoluminescent
product
have
been
used
as
luminescent
tags.
The
combination
of
cyclodextrins
and
allows
obtaining
new
nanoplatform,
biocompatible
material,
both
capabilities,
increasing
well
the
internalization
by
cells
CD,
induced
cyclodextrins.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(9), P. 2761 - 2761
Published: April 25, 2022
In
order
to
improve
the
aqueous
solubility
and
enhance
bioavailability
of
Hyperoside
(Hyp),
three
inclusion
complexes
(ICs)
Hyp
with
2-hydroxypropyl-β-cyclodextrin
(2H-β-CD),
β-cyclodextrin
(β-CD),
methyl-β-cyclodextrin
(M-β-CD)
were
prepared
using
ultrasonic
method.
The
characterization
was
achieved
Fourier-transform
infrared
spectroscopy
(FTIR),
scanning
electronic
microscopy
(SEM),
X-ray
powder
diffraction
(XRPD),
thin-layer
chromatography
(TLC),
1H
nuclear
magnetic
resonance
(1H
NMR).
effects
ICs
on
antioxidant
activity
investigated.
A
Job's
plot
revealed
that
formed
kinds
cyclodextrin
(CD),
all
at
a
1:1
stoichiometric
ratio.
FTIR,
SEM,
XRPD,
TLC,
NMR
results
confirmed
formation
complexes.
water
IC
enhanced
9-fold
compared
original
Hyp.
tests
showed
had
higher
activities
free
in
vitro
H2O2-RAW264.7
cell
model.
Therefore,
encapsulation
CDs
can
not
only
Hyp's
but
also
its
biological
activity,
which
provides
useful
information
for
potential
application
complexation
clinical
context.
Analytica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
1318, P. 342948 - 342948
Published: July 6, 2024
Cyclodextrins
are
a
well-established
system
which
form
inclusion
complexes
with
many
guest
molecules.
This
property
can
be
easily
exploited
to
develop
drug
delivery
systems.
Additionally,
carbon
dots
(CD)
low-toxic
photoluminescent
product
have
been
used
as
luminescent
tags.
The
combination
of
cyclodextrins
and
allows
obtaining
new
nanoplatform,
biocompatible
material,
both
capabilities,
increasing
well
the
internalization
by
cells
CD,
induced
cyclodextrins.