Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 327, P. 121673 - 121673
Published: Dec. 9, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10975 - 10975
Published: Sept. 19, 2022
Chitosan, a naturally abundant cationic polymer, is chemically composed of cellulose-based biopolymers derived by deacetylating chitin. It offers several attractive characteristics such as renewability, hydrophilicity, biodegradability, biocompatibility, non-toxicity, and broad spectrum antimicrobial activity towards gram-positive gram-negative bacteria well fungi, etc., because which it receiving immense attention biopolymer for plethora applications including drug delivery, protective coating materials, food packaging films, wastewater treatment, so on. Additionally, its structure carries reactive functional groups that enable reactions electrochemical interactions at the biomolecular level improves chitosan's physicochemical properties functionality. This review article highlights extensive research about properties, extraction techniques, recent developments chitosan-based composites drug, gene, protein, vaccine delivery applications. Its versatile in tissue engineering wound healing are also discussed. Finally, challenges future perspectives chitosan biomedical elucidated.
Language: Английский
Citations
161
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 807 - 807
Published: March 1, 2023
Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It numerous qualities make it attractive biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, many others. Importantly, chitosan can be fabricated into variety of structures including nanoparticles, scaffolds, hydrogels, membranes, which tailored to deliver desirable outcome. Composite chitosan-based biomaterials have been demonstrated stimulate in vivo the repair various tissues organs, but not limited to, bone, cartilage, dental, skin, nerve, cardiac, other tissues. Specifically, de novo formation, resident stem cell differentiation, extracellular matrix reconstruction were observed multiple preclinical models different injuries upon treatment with formulations. Moreover, proven efficient carriers medications, genes, bioactive compounds since they maintain sustained release these therapeutics. In this review, we discuss most recently published organ well delivery
Language: Английский
Citations
118
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 231, P. 123354 - 123354
Published: Jan. 18, 2023
Language: Английский
Citations
98
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 308, P. 120647 - 120647
Published: Feb. 3, 2023
Language: Английский
Citations
82
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 233, P. 123494 - 123494
Published: Feb. 1, 2023
Language: Английский
Citations
78
International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 217, P. 77 - 87
Published: July 9, 2022
Language: Английский
Citations
77
Small, Journal Year: 2023, Volume and Issue: 19(31)
Published: Feb. 17, 2023
Abstract The emergence and global spread of bacterial resistance to conventionally used antibiotics have highlighted the urgent need for new antimicrobial agents that might replace antibiotics. Currently, nanomaterials hold considerable promise as in anti‐inflammatory therapy. Due their distinctive functional physicochemical characteristics exceptional biocompatibility, carbon dots (CDs)‐based composites attracted a lot attention context these nanomaterials. Here, thorough assessment current developments field CDs‐based is provided, starting with brief explanation general synthesis procedures, categorization, composites. many processes driving antibacterial action are then thoroughly described, including physical destruction, oxidative stress, incorporation agents. Finally, obstacles now suffer combating infectious diseases outlined investigated, along potential applications
Language: Английский
Citations
71
BMEMat, Journal Year: 2023, Volume and Issue: 1(3)
Published: June 30, 2023
Abstract Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings three‐dimensional networks hydrophilic polymers absorb retain large amounts water, have been shown to possess excellent biocompatibility, low toxicity, fluid handling properties. In addition, hydrogels create moist wound environment promotes healing by supporting cell proliferation, migration, angiogenesis. Hydrogels, therefore, emerged as promising for promoting DFU healing. this review, we attempt chart the landscape emerging field hydrogel dressing treatment. We will explicitly review assorted preparation methods well detailed discussion various types deployed study. also crystallize key findings, identify remaining challenges, present an outlook on future development enticing field.
Language: Английский
Citations
67
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 321, P. 121318 - 121318
Published: Aug. 23, 2023
Language: Английский
Citations
62
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127882 - 127882
Published: Nov. 10, 2023
Language: Английский
Citations
54