Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(21), P. 6328 - 6353
Published: May 20, 2022
HMOs
(human
milk
oligosaccharides)
are
the
third
most
important
nutrient
in
breast
milk.
As
complex
glycans,
play
an
role
regulating
neonatal
intestinal
immunity,
resisting
viral
and
bacterial
infections,
displaying
anti-inflammatory
characteristics,
promoting
brain
development.
Although
there
have
been
some
previous
reports
of
HMOs,
a
detailed
literature
review
summarizing
structure-activity
relationships
dose-dependent
effects
is
lacking.
Hence,
after
introducing
structures
synthetic
pathways
this
summarizes
categorizes
identified
structure-function
HMOs.
Differential
mechanisms
different
structural
utilization
by
microorganisms
summarized.
This
also
emphasizes
recent
advances
interactions
between
health
benefits
variance
dosage
effect
based
on
vitro
cell
tests,
animal
experiments,
human
intervention
studies.
The
potential
chemical
structure,
selection,
physiological
properties
as
functional
foods
vital
for
further
understanding
their
future
applications.
Foods,
Journal Year:
2024,
Volume and Issue:
13(6), P. 921 - 921
Published: March 18, 2024
The
impact
of
five
human
milk
oligosaccharides
(HMOs)—2′-fucosyllactose
(2FL),
3′-sialyllactose
(3SL),
6′-sialyllactose
(6SL),
lacto-N-tetraose
(LNT),
and
lacto-N-neotetraose
(LNnT)—on
the
gut
microbiota
short-chain
fatty
acid
(SCFA)
metabolites
in
infants
aged
0–6
months
was
assessed
through
vitro
fermentation.
Analyses
influence
different
HMOs
on
composition
distribution
infant
SCFA
levels
were
conducted
using
16S
rRNA
sequencing,
quantitative
real-time
PCR
(qPCR),
gas
chromatography
(GC),
respectively.
findings
indicated
crucial
role
initial
shaping
fermentation
outcomes.
Fermentation
maintained
dominant
genera
species
intestine
but
influenced
their
abundance
distribution.
Most
10
Bifidobacteria
strains
effectively
utilized
or
degradation
products,
particularly
demonstrating
proficiency
utilizing
2FL
sialylated
compared
to
non-fucosylated
neutral
HMOs.
Moreover,
our
study
B.
infantis-dominant
breve-dominant
as
inocula
revealed
varying
acetic
produced
by
upon
HMO
degradation.
Specifically,
strain
yielded
notably
higher
than
(p
=
0.000),
with
minimal
propionic
butyric
production
observed
at
fermentation’s
conclusion.
These
suggest
potential
utilization
developing
microbiota-targeted
foods
for
infants.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 19, 2024
Abstract
Respiratory
viral
infections,
a
major
public
health
concern,
necessitate
continuous
development
of
novel
antiviral
strategies,
particularly
in
the
face
emerging
and
re-emerging
pathogens.
In
this
study,
we
explored
potential
human
milk
oligosaccharides
(HMOs)
as
broad-spectrum
agents
against
key
respiratory
viruses.
By
examining
structural
mimicry
host
cell
receptors
their
known
biological
functions,
including
activities,
assessed
ability
HMOs
to
bind
potentially
inhibit
proteins
crucial
for
entry.
Our
silico
analysis
focused
on
integral
host-virus
interactions,
namely
hemagglutinin
protein
influenza,
fusion
syncytial
metapneumovirus,
spike
SARS-CoV-2.
Using
molecular
docking
simulation
studies,
demonstrated
that
exhibit
varying
binding
affinities
these
proteins,
suggesting
entry
inhibitors.
This
study
identified
several
with
promising
profiles,
highlighting
drug
development.
research
provides
foundation
utilizing
natural
source
designing
new
therapeutics,
offering
approach
fight
infections.
Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(21), P. 6328 - 6353
Published: May 20, 2022
HMOs
(human
milk
oligosaccharides)
are
the
third
most
important
nutrient
in
breast
milk.
As
complex
glycans,
play
an
role
regulating
neonatal
intestinal
immunity,
resisting
viral
and
bacterial
infections,
displaying
anti-inflammatory
characteristics,
promoting
brain
development.
Although
there
have
been
some
previous
reports
of
HMOs,
a
detailed
literature
review
summarizing
structure-activity
relationships
dose-dependent
effects
is
lacking.
Hence,
after
introducing
structures
synthetic
pathways
this
summarizes
categorizes
identified
structure-function
HMOs.
Differential
mechanisms
different
structural
utilization
by
microorganisms
summarized.
This
also
emphasizes
recent
advances
interactions
between
health
benefits
variance
dosage
effect
based
on
vitro
cell
tests,
animal
experiments,
human
intervention
studies.
The
potential
chemical
structure,
selection,
physiological
properties
as
functional
foods
vital
for
further
understanding
their
future
applications.
