The Contribution of Silk Fibroin in Biomedical Engineering

Insects, Journal Year: 2022, Volume and Issue: 13(3), P. 286 - 286

Published: March 14, 2022

Silk fibroin (SF) is a natural protein (biopolymer) extracted from the cocoons of Bombyx mori L. (silkworm). It has many properties interest in field biotechnology, most important being biodegradability, biocompatibility and robust mechanical strength with high tensile strength. SF usually dissolved water-based solvents can be easily reconstructed into variety material formats, including films, mats, hydrogels, sponges, by various fabrication techniques (spin coating, electrospinning, freeze-drying, physical or chemical crosslinking). Furthermore, feasible used biomedical applications, tissue engineering (3D scaffolds, wounds dressing), cancer therapy (mimicking tumor microenvironment), controlled drug delivery (SF-based complexes), bone, eye skin regeneration. In this review, we describe structure, composition, general properties, structure–properties relationship SF. addition, main methods for ecological extraction processing that make it green are discussed. Lastly, technological advances use SF-based materials addressed, especially healthcare applications such as therapeutics.

Language: Английский

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Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

ACS Biomaterials Science & Engineering, Journal Year: 2022, Volume and Issue: 8(6), P. 2321 - 2335

Published: May 31, 2022

Large-sized bone defects are a great challenge in clinics and considerably impair the quality of patients' daily life. Tissue engineering strategies using cells, scaffolds, bioactive molecules to regulate microenvironment regeneration is promising approach. Zinc, magnesium, iron ions natural elements tissue participate many physiological processes metabolism therefore have potential for regeneration. In this review, we performed systematic analysis on effects zinc, engineering. We focus role these properties scaffolds (mechanical strength, degradation, osteogenesis, antibacterial properties, etc.). hope that our summary current research achievements notifications improve repair will find new inspiration breakthroughs inspire future research.

Language: Английский

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Smart/stimuli-responsive hydrogels: State-of-the-art platforms for bone tissue engineering

Applied Materials Today, Journal Year: 2022, Volume and Issue: 29, P. 101560 - 101560

Published: June 22, 2022

Language: Английский

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Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(1), P. 585 - 611

Published: Jan. 5, 2024

Numerous surgeries are carried out to replace tissues that have been harmed by an illness or accident. Due various surgical interventions and the requirement of bone substitutes, emerging field tissue engineering attempts repair damaged with help scaffolds. These scaffolds act as template for regeneration controlling development new cells. For creation functional organs, there three elements play very crucial role: cells, signals achievement these aims, types natural polymers, like chitosan, chitin, cellulose, albumin silk fibroin, used preparation Scaffolds produced from polymers many advantages: they less immunogenic well being biodegradable, biocompatible, non-toxic cost effective. The hierarchal structure bone, microscale nanoscale, is mostly made up organic inorganic components nanohydroxyapatite collagen components. This review paper summarizes knowledge updates information about use scaffolds, their application in recent research trends area (BTE). article extensively explores related analyze advancement nanotechnology treatment bone-related diseases repair.

Language: Английский

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Application of Nano-Inspired Scaffolds-Based Biopolymer Hydrogel for Bone and Periodontal Tissue Regeneration

Polymers, Journal Year: 2022, Volume and Issue: 14(18), P. 3791 - 3791

Published: Sept. 10, 2022

This review’s objectives are to provide an overview of the various kinds biopolymer hydrogels that currently used for bone tissue and periodontal regeneration, list advantages disadvantages using them, assess how well they might be nanoscale fabrication biofunctionalization, describe their production processes functionalization with active biomolecules. They applied in conjunction other materials (such as microparticles (MPs) nanoparticles (NPs)) novel techniques replicate physiological generation more faithfully. Enhancing biocompatibility created from blends natural synthetic biopolymers can result creation best scaffold match extracellular matrix (ECM) regeneration. Additionally, adding increase hydrogel stability a number biological effects. In this review, research study polysaccharide will critical creating valuable effective future impact predicted repairing defects.

Language: Английский

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3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 8, 2022

Abstract Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability excellent mechanical properties. Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) CNC extracted Ficus thonningii . Scanning electron microscopy revealed that printed exhibit interconnected pores with an estimated average pore size approximately 400 µm. Incorporating 3% (w/w) into improved PLA properties (Young's modulus increased by ~ 30%) wettability (water contact angle decreased 17%). The mineralization process simulated body fluid was validated nucleation hydroxyapatite confirmed. Additionally, cytocompatibility tests CNC-based non-toxic compatible bone cells. Our design, based on rapid printing PLA/CNC composites, combines ability control architecture provide biological scaffolds, which opens perspectives for applications tissue engineering regenerative medicine.

Language: Английский

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Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System

ACS Nano, Journal Year: 2022, Volume and Issue: 16(8), P. 11755 - 11768

Published: July 14, 2022

Although studies on scaffolds for tissue generation have mainly focused the chemical composition and pore structure, effects of scaffold shape been overlooked. Scaffold determines surface area (SA) at single-scaffold level (i.e., microscopic effects), although it also affects amount interscaffold space in defect whole-system macroscopic effects). To clarify these effects, this study reports osteogenesis abilities three types carbonate apatite granular with different shapes, namely, irregularly shaped dense granules (DGs) two honeycomb (HCGs) seven hexagonal channels (∼255 μm length between opposite sides). The HCGs possessed either 12 protuberances (∼75 length) or no protuberances. Protuberances increased SA each granule by 3.24 mm

Language: Английский

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Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

npj Regenerative Medicine, Journal Year: 2023, Volume and Issue: 8(1)

Published: Feb. 25, 2023

Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural structure as a template, constructing an engineered repair module is important scheme to realize functional regeneration and of maxillofacial tissue. Here, inspired biomineralization process, we constructed composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) dentin (TDM). The dynamic network composed Ca2+·COO- coordination ACPs made loaded with TDM, exhibited self-repairing ability injectability. mechanical properties can be regulated, but activity TDM remains unaffected. Cytological studies animal models show that promote odontogenesis osteogenic differentiation mesenchymal stem cells, adapt irregular defects, in situ defective tooth bone tissues. In summary, this paper shows injectable based on biomimetic mineralization theory induce formation dentin/bone regeneration.

Language: Английский

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Polyphenolic-modified cellulose acetate membrane for bone regeneration through immunomodulation

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 305, P. 120546 - 120546

Published: Jan. 5, 2023

Language: Английский

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A Comprehensive Review on Silk Fibroin as a Persuasive Biomaterial for Bone Tissue Engineering

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2660 - 2660

Published: Jan. 31, 2023

Bone tissue engineering (BTE) utilizes a special mix of scaffolds, cells, and bioactive factors to regulate the microenvironment bone regeneration form three-dimensional simulation structure regenerate tissue. Silk fibroin (SF) is perhaps most encouraging material for BTE given its tunable mechanical properties, controllable biodegradability, excellent biocompatibility. Numerous studies have confirmed significance SF stimulating formation. In this review, we start by introducing characteristics SF. After that, immunological mechanism osteogenesis summarized, various forms biomaterials latest development prospects in are emphatically introduced. Biomaterials based on great potential engineering, review will serve as resource future design research.

Language: Английский

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