Orally administrated fucoidan and its low-molecular-weight derivatives are absorbed differentially to alleviate coagulation and thrombosis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 255, P. 128092 - 128092

Published: Nov. 17, 2023

Language: Английский

---

Size exclusion chromatography and asymmetrical flow field-flow fractionation for structural characterization of polysaccharides: A comparative review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134236 - 134236

Published: July 29, 2024

Language: Английский

---

Inhibitory effect of fucoidan on TNF-α-induced inflammation in human retinal pigment epithelium cells

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: April 12, 2023

Sargassum horneri (S. horneri) is a brown seaweed that contains fucose-rich sulfated polysaccharide called fucoidan and known to possess beneficial bioactivities, such as anti-inflammatory, antiviral, antioxidative, antitumoral effects. This study aimed determine the anti-inflammatory effects of AB_SH (hydrothermal extracts from S. its bioactive compound (fucoidan) against tumor necrosis factor alpha (TNF-α)-induced inflammation in human retinal pigment epithelial (RPE) cells. did not exhibit any cytotoxicity, it decreased mRNA expression interleukin (IL)-6 IL-8 production cytokines IL-6 TNF-α. It also suppressed levels phosphorylated nuclear kappa B (NF-κB) mitogen-activated protein kinases (MAPKs), including c-Jun amino-terminal (JNK), p38 (p38), extracellular signal-regulated kinase (ERK) proteins, suggesting inhibits activation NF-kB/MAPK signaling pathway. Since was identified composition analysis AB_SH, additionally shown be required for TNF-α-stimulated RPE In line with results, reduced IL-6, IL-1ß, TNF-α, through downregulation pathway dose-dependent manner. Collectively, ability hydrothermal reduce indicates may good functional ingredient managing ocular disorders.

Language: Английский

---

A Hypertonic Seawater Nasal Irrigation Solution Containing Algal and Herbal Natural Ingredients Reduces Viral Load and SARS-CoV-2 Detection Time in the Nasal Cavity

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(7), P. 1093 - 1093

Published: July 3, 2023

Nasal irrigation is thought to decrease the viral load present in nasal cavity. Our aim was assess effect of a hypertonic seawater solution [with algal and herbal natural ingredients (Sinomarin®)] on nasopharynx patients hospitalized with severe COVID-19 pneumonia. We conducted prospective, randomized, controlled trial from June 2022 December 2022. allocated 56 pneumonia into two groups (28 each group)—the group [nasal irrigations (Sinomarin®) every 4 h for 16 per day, consecutive days] control (no irrigations). A second nasopharyngeal swab collected 48 after baseline (8 last wash group) estimate SARS-CoV-2 as determined by cycle threshold (Ct) values. In group, mean Ct values significantly increased days initial measurement [ΔCt 48−0 = 3.86 ± 3.03 cycles, p < 0.001 (95%CI: 2.69 5.04)]. No significant differences were observed −0.14 4.29, 0.866 −1.80 −1.52)]. At follow-up, 17 had negative test results compared only 9 (p 0.03). containing decreased detection time

Language: Английский

---

The physiological activities of fucoidan and its application in animal breeding

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 147, P. 109458 - 109458

Published: Feb. 16, 2024

Language: Английский

---