Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121408 - 121408

Published: Sept. 17, 2023

Language: Английский

---

Polymeric biomaterials for wound healing

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: July 27, 2023

Skin indicates a person’s state of health and is so important that it influences emotional psychological behavior. In this context, the effective treatment wounds major concern, since several conventional wound healing materials have not been able to provide adequate healing, often leading scar formation. Hence, development innovative biomaterials for essential. Natural synthetic polymers are used extensively dressings scaffold production. Both natural beneficial properties limitations, they in combination overcome their individual limitations. The use different production has proven be promising alternative wounds, as capacity accelerate process demonstrated many studies. Thus, work focuses on describing currently commercially available solutions management skin such polymeric substitutes. New directions, strategies, technologies design also addressed, providing deep burns, personalized care faster healing.

Language: Английский

---

Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1679 - 1696

Published: Feb. 1, 2025

Background: A paramount issue in the realm of chronic wound healing among diabetic patients is pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays process such wounds. Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within temperature-sensitive injectable hydrogel, presents an intriguing strategy for closure various irregular wounds, modulation responses, and promotion angiogenesis. Methods: Herein, ZIF-8 loaded with curcumin (Cur) combined methylcellulose/carboxymethyl chitosan (MCC) thermosensitive hydrogel was described. The assessment encompassed properties, pH-responsive release, antimicrobial activity, ROS scavenging capabilities MCC@ZIF-8@Cur hydrogel. series studies were conducted to explore its biocompatibility, pro-angiogenic effects, macrophage M2 polarization induction. Additionally, full-thickness skin defect model rat established investigate hydrogel's multifaceted efficacy facilitating repair, mitigating fostering Results: possess attribute being capable situ formation (gelation temperature ≥ 28 °C), establishing effective physical barrier multitude profiles. incorporation ZIF-8@Cur confers exceptional antibacterial properties capability eliminate reactive oxygen species (ROS). Moreover, continuously releases Cur Zn 2+ , inflammation, inducing macrophages, promoting This creates favorable immune microenvironment conducive regeneration, accelerating In vivo have demonstrated markedly accelerated ratio rats group compared Control ( p < 0.001). By 14th day healing, achieved remarkable 97.22%, considerably surpassing (72.98%), showcasing potential treating Conclusion: findings demonstrate successful creation exhibits capabilities. effectively suppresses modulates macrophages towards phenotype, promotes thus regeneration. These attributes collectively augur promising prospects applications Keywords: wound, microenvironment, polarization, angiogenesis

Language: Английский

---

A TA/Cu2+ Nanoparticle Enhanced Carboxymethyl Chitosan-Based Hydrogel Dressing with Antioxidant Properties and Promoting Wound Healing

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 231 - 245

Published: Jan. 1, 2024

Background: As the first line of immune defense and largest organ body, skin is vulnerable to damage caused by surgery, burns, collisions other factors. Wound healing in a long complex physiological process that influenced number different Proper wound care can greatly improve speed reduce generation scars. However, traditional dressings (bandages, gauze, etc.) often used clinical practice have single function, lack active ingredients are limited use. Hydrogels with three-dimensional network structure potential biomedical material because their physical chemical environment similar extracellular matrix. In particular, hydrogel low price, good biocompatibility, degradability, antibacterial angiogenic activity favored public. Methods: Here, carboxymethyl chitosan-based dressing (CMCS-TA/Cu 2+ ) reinforced copper ion crosslinked tannic acid (TA/Cu nanoparticles was developed. This study investigated characteristics, cytotoxicity, angiogenesis TA/Cu CMCS-TA/Cu hydrogels. Furthermore, full-thickness defect model employed assess vivo capacity dressings. Results: The introduction not only could increase mechanical properties but also continuously releases ions promote cell migration (the reach 92% at 48 h) tubule formation, remove free radicals (repair rate 90% 9 days). Conclusion: Experiments proved has cytocompatibility, antioxidant ability, providing an advantageous solution for repair. Keywords: nanoparticles, chitosan, dressing,

Language: Английский

---

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 155 - 155

Published: Jan. 23, 2024

Wound infection due to bacterial invasion at the wound site is one of primary challenges associated with delayed healing. Microorganisms tend form biofilms that protect them from harm, leading their multidrug resistance. The alarming increase in antibiotic resistance poses a threat Hence, urgent need for novel dressing materials capable managing crucial expediting recovery. There considerable interest polymeric dressings embedded bioactive substances, such as metal-based nanoparticles, potential solutions treating microbially infected wounds. Metal-based nanoparticles have been widely used management wounds broad antimicrobial efficacy. This review focuses on polymer-based and loaded like silver, gold, magnesium oxide, or zinc oxide. When compared, oxide-loaded exhibited higher antibacterial activity against Gram-positive strains silver nanoparticle-loaded gram-negative strains. However, infused both displayed synergistic effect bacteria. Furthermore, these antibiofilm generation reactive oxygen species while accelerating closure vitro vivo.

Language: Английский

---

A Tough Janus Hydrogel Patch with Strong Wet Adhesion and Self-Debonding for Oral Ulcer Treatment

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(10), P. 4976 - 4989

Published: May 9, 2024

Oral ulcers (OU) are the most common oral mucosal disease in humans across all geographic regions, seriously affecting patients' quality of life and even leading to irreversible loss function. Existing clinical treatments, such as ointments, sprays, patches, often washed out by saliva within a few hours, posing challenges for dentists. Adhesive hydrogel dressings show promise address these issues, but existing options lack wet adhesion, flexibility, gentle debonding, limiting their application dynamic environments like cavity. To overcome limitations, hydrogen-bond-based Janus patch was developed. N-[Tris(hydroxymethyl)methyl]-acrylamide (THMA) chitosan (CS) were selected composites adhesive layer this hydrogel, high-density hydrogen bonding provided THMA topological adhesion synergy CS greatly enhanced performance hydrogel. A high-tenacity poly(ethylene glycol) diacrylate (PEGDA)-based acts tough layer, providing effective physical barrier. The can instantly adhere wound withstand chewing, biting, other mouth movements; avoid external stimulation; continuously release drugs promote repair diseases. In particular, gently automatically debond after drug delivery, thereby achieving convenient operation excellent therapeutic efficacy.

Language: Английский

---

Cu-MSNs and ZnO nanoparticles incorporated poly(ethylene glycol) diacrylate/sodium alginate double network hydrogel for simultaneous enhancement of osteogenic differentiation

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 236, P. 113804 - 113804

Published: Feb. 17, 2024

Language: Английский

---

Biomimetic Nanostructural Materials Based on Placental Amniotic Membrane-derived Nanofibers for Self-healing and Anti-adhesion during Cesarean Section

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123081 - 123081

Published: Jan. 1, 2025

Language: Английский

---

Growth of Silver Nanoparticles Embedded in a Polyacrylamide—Alginate Hybrid Hydrogel

Crystals, Journal Year: 2025, Volume and Issue: 15(3), P. 211 - 211

Published: Feb. 23, 2025

Hydrogels represent a versatile class of materials with remarkable potential as three-dimensional matrices for nanoparticle integration. This study explores the mechanism silver formation within polyacrylamide–alginate hybrid hydrogel, employing controlled reduction–oxidation reaction between nitrate (AgNO3) and sodium borohydride (NaBH4) across temperature gradient (5–70 °C). Characterization techniques, including Raman, infrared, UV-Vis spectroscopies, X-ray diffraction, scanning electron microscopy, were employed to analyze structural optical properties nanoparticles hydrogel. The results show that, rose, numbers decreased, while their size increased. Consistently octahedral in shape averaging 100–120 nm, these revealed temperature-dependent growth pattern, rare larger crystals emerging more frequently at higher temperatures. findings highlight hydrogels effective incorporation metal nanoparticles, paving way applications drug delivery, biosensing, antimicrobial treatments.

Language: Английский

---

Research progress on antimicrobial hydrogel dressing for wound repair

European Polymer Journal, Journal Year: 2023, Volume and Issue: 197, P. 112372 - 112372

Published: Aug. 19, 2023

Language: Английский

---