Dalton Transactions,
Journal Year:
2024,
Volume and Issue:
53(6), P. 2826 - 2832
Published: Jan. 1, 2024
Bacterial
infections
are
a
big
challenge
in
clinical
treatment,
making
it
urgent
to
develop
innovative
antibacterial
systems
and
therapies
combat
bacterial
infections.
APL Bioengineering,
Journal Year:
2024,
Volume and Issue:
8(2)
Published: April 2, 2024
The
tumor
microenvironment
(TME),
composed
of
and
influenced
by
a
heterogeneous
set
cancer
cells
an
extracellular
matrix,
plays
crucial
role
in
progression.
biophysical
aspects
the
TME
(namely,
its
architecture
mechanics)
regulate
interactions
spatial
distributions
immune
cells.
In
this
review,
we
discuss
factors
TME—notably,
as
well
stromal
cells—that
contribute
to
pro-tumor,
immunosuppressive
response.
We
then
ways
which
innate
adaptive
systems
respond
tumors
from
both
biochemical
perspectives,
with
increased
focus
on
CD8+
CD4+
T
Building
upon
information,
turn
immune-based
antitumor
interventions—specifically,
recent
breakthroughs
aimed
at
improving
CAR-T
cell
therapy.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(14), P. 17080 - 17091
Published: April 1, 2024
Psoriasis
is
a
systemic,
recurrent,
chronic
autoimmune
skin
disease.
However,
psoriasis
drugs
have
poor
permeability
and
high
toxicity,
resulting
in
low
bioavailability
affecting
their
clinical
application.
In
this
study,
we
propose
curcumin-based
ionic
liquid
hydrogel
loaded
with
ilomastat
(Cur-Car-IL@Ilo
hydrogel),
which
can
effectively
maintain
the
sustained
release
of
improve
drugs.
We
used
model
imiquimod-induced
demonstrated
that
local
application
Cur-Car-IL@Ilo
lesions
mice
significantly
reduced
expression
levels
inflammatory
factors,
matrix
metalloproteinase
8,
collagen-I.
The
expressions
iron
death-related
proteins
SLC7A11
ASL4
were
decreased
after
treatment
hydrogel.
Flora
analysis
showed
content
anaerotruncus,
proteus,
UCG-009
bacteria
gut
psoriatic
increased.
paludicola,
parabacteroides,
prevotellaceae_UCG-001,
escherichia-shigella,
aerococcus
decreased,
some
above
tended
to
be
normal
treatment.
Therefore,
as
multifunctional,
nonirritating,
noninvasive,
highly
effective
percutaneous
psoriasis.
