Recent advances in the biosynthesis of fungal glucan structural diversity

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 329, P. 121782 - 121782

Published: Jan. 7, 2024

Language: Английский

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Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116592 - 116592

Published: April 13, 2024

Multiple epigenetic factors play a regulatory role in maintaining the homeostasis of cutaneous components and are implicated aging process skin. They have been associated with activation senescence program, which is primary contributor to age-related decline Senescent species drive series interconnected processes that impact immediate surroundings, leading structural changes, diminished functionality, heightened vulnerability infections. Geroprotective medicines may restore balance represent valid therapeutic alliances against skin aging. Most them well-known Western medications such as metformin, nicotinamide adenine dinucleotide (NAD+), rapamycin, histone deacetylase inhibitors, while others belong Traditional Chinese Medicine (TCM) remedies for scientific literature provides limited information. With help Geroprotectors.org database comprehensive analysis referenced literature, we compiled data on compounds formulae shown potential preventing identified modulators.

Language: Английский

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A comprehensive review on the potential applications of medicine Polygonatum species in the food sector

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104116 - 104116

Published: April 17, 2024

Language: Английский

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Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(3), P. 215 - 215

Published: March 14, 2024

Aging is a complex biological process that influenced by both intrinsic and extrinsic factors. Recently, it has been discovered reactive oxygen species can accelerate the aging process, leading to an increased incidence of age-related diseases are characteristic aging. This review aims discuss potential mushrooms as dietary intervention for anti-aging, focusing on their nutritional perspective. Mushrooms contain various bioactive compounds, including carbohydrates, proteins, fungal lipids, phenolic compounds. These compounds have shown promising effectiveness in combating skin diseases. In vitro vivo studies demonstrated treatments with or extracts significantly extend lifespan improve health span. Furthermore, aimed elucidate precise cellular molecular mechanisms action structure–activity relationship mushroom findings provide strong basis further research, human clinical trials investigations, explore benefits real-life anti-aging practices. By exploring effects mushrooms, this valuable insights contribute development broader strategies healthy

Language: Английский

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Biotechnological potential of yeast cell wall: An overview

Biotechnology Progress, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Abstract The yeast cell wall is a complex structure whose main function to protect the from physical and chemical damage, providing it with rigidity. It composed of matrix covalently linked polysaccharides proteins, including β‐glucans, mannoproteins, chitin, proportion can vary according species environmental conditions. components have relevant properties that expand possibilities use in different industrial sectors, such as pharmaceutical, food, medical, veterinary, cosmetic. Some applications include bioremediation, enzyme immobilization, animal feed, wine production, hydrogel production. In literature description composition model like Saccharomyces cerevisiae Candida albicans , however, important know this or culture medium Thus, understanding structural holds promise an alternative expanding utilization residual bioprocesses. context circular economy, conversion into valuable products attractive prospect for researchers aiming develop sustainable technologies. This review provides overview its significance biotechnological applications, considering prospects increase diversification these compounds industry.

Language: Английский

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β-Glucans obtained from fungus for wound healing: A review

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 327, P. 121662 - 121662

Published: Dec. 4, 2023

Language: Английский

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Combined Strategy Using High Hydrostatic Pressure, Temperature and Enzymatic Hydrolysis for Development of Fibre-Rich Ingredients from Oat and Wheat By-Products

Foods, Journal Year: 2024, Volume and Issue: 13(3), P. 378 - 378

Published: Jan. 24, 2024

Wheat bran (WB) and oat hull (OH) are two interesting undervalued cereal processing sources rich in total dietary fibre (TDF) other associated bioactive compounds, such as β-glucans polyphenols. The aim of this study was to optimise a combination chemical (enzymes) physical (high hydrostatic pressure-temperature) strategies increase the bioaccessibility compounds naturally bound outer layers. WB OH were hydrolysed using food-grade enzymes (UltraFloXL Viscoferm, for OH, respectively) with HPP at different temperatures (40, 50, 60 70 °C) hydrolysis either before or after HPP. Proximal composition, phytic acid, β-glucans, phenolics (TPs) antioxidant activity (TAC) evaluated select conditions optimal nutritional properties final ingredients. application step treatment resulted lower acid levels both matrices (WB OH). On hand, release β-glucan more effective highest temperature (70 used during pressurisation. After treatment, TP content ranged from 756.47 1395.27 µmol GAE 100 g−1 WB, showed values 566.91 930.45 g−1. An interaction effect between timing (applied HPP) observed case OH. Hydrolysis applied efficient releasing TPs (40–50 °C); meanwhile, higher (60–70 °C), yielded when This not where results significantly correlated TAC values. that process (hydrolysis °C WB; OH) can biological value ingredients obtained.

Language: Английский

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Development of a Cascade-Targeting Oral Vaccine via Glycoprotein 2 on Intestinal Microfold Cells for Cancer Immunotherapy

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Oral cancer vaccines are convenient and safe, with the presence of gut-associated lymphoid tissue (GALT) involved intestinal Peyer's patch (PPs) containing microfold (M) cells housing abundant underneath dendritic (DCs). Here, we found that endocytic receptors glycoprotein 2 (GP2) dectin-1 respectively expressed on M DCs high specificity. Then, discovered a gastrointestinal hydrolysis-resistant D-peptide DGPBP-2(1-8) targeting GP2 by phage display screening optimization. was conjugated to β-glucan (dectin-1 ligand)-containing yeast capsules (GP2-YCs) design cascade-targeting oral vaccine platform, which can help antigen efficiently cross subsequently be endocytosed DCs, thus activating CD8+ T cells. More importantly, this evoke not only cellular but also humoral mucosal immune responses. Therefore, could serve as novel platform for immunotherapy infectious disease prevention well.

Language: Английский

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Characterization of ultrasonicated and ozonated oat 1, 4-β-D-glucan

Innovative Food Science & Emerging Technologies, Journal Year: 2025, Volume and Issue: 102, P. 103977 - 103977

Published: Feb. 26, 2025

Language: Английский

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The challenges faced by multifunctional ingredients: A critical review from sourcing to cosmetic applications

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103463 - 103463

Published: Feb. 27, 2025

Language: Английский

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