Journal of Food Biochemistry,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
As
widely
used
in
traditional
Chinese
medicine
and
nutritional
food,
Polygonati
Rhizom
is
known
for
its
diverse
pharmacological
properties,
including
hematopoiesis,
immune
enhancement,
antitumor,
anti‐inflammatory,
antioxidant,
antiaging,
antiviral,
hepatoprotection.
polysaccharides
(PRPs)
are
primary
bioactive
compounds
that
water‐soluble
mainly
comprise
fructose
(Fru),
glucose
(Glc),
galactose
(Gal),
arabinose
(Ara),
rhamnose
(Rha),
fucose
(Fuc),
xylose
(Xyl),
glucuronic
acid
(GlcA),
galacturonic
(GalA).
Meanwhile,
different
extraction
methods,
such
as
hot
water
ultrasonic
extractions,
can
significantly
affect
the
yield
of
PRPs,
Additionally,
PRPs
were
also
reported
to
hold
promising
potential
a
drug
carrier.
Herein,
extraction,
structure
elucidation,
biological
activities,
carrier
applications
systematically
summarized,
providing
reference
further
research
development
Rhizom.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116330 - 116330
Published: Feb. 28, 2024
Traditional
Chinese
medicine
polysaccharides
(TCMPs)
have
gained
increasing
attention
in
the
field
of
nanomedicine
due
to
their
diverse
biological
activities
and
favorable
characteristics
as
drug
carriers,
including
biocompatibility,
biodegradability,
safety,
ease
modification.
TCMPs-based
nano-drug
delivery
systems
(NDDSs)
offer
several
advantages,
such
evasion
reticuloendothelial
system
(RES)
phagocytosis,
protection
against
biomolecule
degradation,
enhanced
bioavailability,
potent
therapeutic
effects.
Therefore,
a
comprehensive
review
latest
developments
NDDSs
applications
disease
therapy
is
great
significance.
This
provides
an
overview
structural
TCMPs
relevant
carrier
design,
strategies
employed
for
constructing
NDDSs,
versatile
role
these
systems.
Additionally,
current
challenges
future
prospects
are
discussed,
aiming
provide
valuable
insights
research
clinical
translation.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(3), P. 297 - 297
Published: Feb. 26, 2024
Intestinal
mucositis
(IM)
is
a
common
adverse
effect
of
chemotherapy,
limiting
its
clinical
application.
Codonopsis
pilosula-derived
CP-A
(an
inulin-type
fructan)
an
edible
Chinese
medicine
with
anti-inflammatory
and
gastrointestinal
protective
effects,
which
may
be
useful
for
treating
IM.
Here,
we
explored
CP-A’s
role
in
ameliorating
IM
induced
by
5-fluorouracil
(5-FU)
investigated
the
underlying
mechanism
using
vitro
experiments
rat
models.
Western
blotting,
immunohistochemistry
(IHC),
real-time
PCR
(RT-PCR)
analyses
were
used
to
assess
protein
expression
related
extracellular-regulated
kinases
(ERK)/myosin
light
chain
kinase
(MLCK)/myosin
2
(MLC2)
signaling
pathway
tight
junction
proteins.
Inflammatory
factors
quantified
enzyme-linked
immunosorbent
assays
(ELISAs),
16S
rRNA
amplicon
sequencing
was
employed
cecum
content
analysis.
The
results
indicated
that
restored
body
weight
food
intake
reversed
histopathological
changes
rats.
Further,
abnormal
MLCK
activation
5-FU
attenuated
via
ERK/MLCK/MLC2
pathway.
treatment
improved
levels
reduced
inflammatory
factor
expression.
Moreover,
intervention
regulated
intestinal
microbiota
community
structure,
increasing
abundance
Lactobacillus
decreasing
Shigella.
In
conclusion,
mitigates
5-FU-induced
inhibiting
pathway,
reducing
factors,
improving
mucosal
barrier,
regulating
microbial
community.
This
study
highlights
therapeutic
potential
provides
insights
future
research.
