Research progress on cancer-associated fibroblasts in osteosarcoma DOI

Liwen Feng,

Yuting Chen,

W Jin

et al.

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 0(0), P. 1 - 10

Published: Jan. 1, 2024

Osteosarcoma (OS) is a prevalent primary bone malignancy with limited treatment options. Therefore, it imperative to investigate and understand the mechanisms underlying OS pathogenesis. Cancer-associated fibroblasts (CAFs) are markedly abundant in tumor stromal cells essentially involved modulation of occurrence development. In recent years, CAFs have become hotspot as researchers aim elucidate CAF that regulate progression. However, most studies on few common cancers, their association remains elusive. This review describes role current knowledge OS, focusing potential cellular origin, classification, diverse functionality. It was found influenced cell signaling, proliferation, invasion, metastasis, epithelial-mesenchymal transition, stemness maintenance, angiogenesis, ability modify immune system components. Furthermore, findings other cancers indicated effective therapeutic strategies included manipulation activation, targeting CAF-derived components, depletion by biomarkers. provides new insights theoretical basis for research.

Language: Английский

Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Modelling Cancer Pathophysiology: Mechanisms and Changes in the Extracellular Matrix During Cancer Initiation and Early Tumour Growth DOI Open Access
Luis Larrea Murillo, Megan Green, Niall Mahon

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(10), P. 1675 - 1675

Published: May 15, 2025

Cancer initiation and early tumour growth are complex processes influenced by multiple cellular microenvironmental factors. A critical aspect of progression is the dynamic interplay between cancer cells extracellular matrix (ECM), which undergoes significant alterations to support malignancy. The loss cell polarity an hallmark progression, disrupting normal tissue architecture fostering cancerous transformation. Circumstantially, cancer-associated microRNAs (miRNAs) regulate key oncogenic processes, including ECM remodelling, epithelial-to-mesenchymal transition (EMT), tumorigenic vascular development, further driving growth. alterations, particularly changes in stiffness mechanotransduction signals, create a supportive niche for cells, enhancing their survival, proliferation, invasion. EMT its subtype, epithelial-to-endothelial (EET), contribute plasticity, promote generation stem (CSCs), vascularisation. Furthermore, development like vasculogenesis angiogenesis sustaining growth, supplying oxygen nutrients hypoxic malignant within evolving microenvironments. This review explores mechanisms underlying these microenvironments, with emphasis on collective role It will delve into present vitro modelling strategies developed closely mimic pathophysiology. Understanding crucial developing targeted therapies aimed at cancer-promoting pathways improving clinical outcomes.

Language: Английский

Citations

0
Recent advancements and challenges in 3D bioprinting for cancer applications DOI
Swayam Aryam Behera, Binita Nanda, P. Ganga Raju Achary

et al.

Bioprinting, Journal Year: 2024, Volume and Issue: 43, P. e00357 - e00357

Published: Sept. 13, 2024

Language: Английский

Citations

1
Tunable Hybrid Hydrogels of Alginate and Cell‐Derived dECM to Study the Impact of Matrix Alterations on Epithelial‐to‐Mesenchymal Transition DOI Creative Commons
Patrícia Barros da Silva,

Xiaoyu Zhao,

Sílvia J. Bidarra

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Epithelial‐to‐mesenchymal transition (EMT) is crucial for tumor progression, being linked to alterations in the extracellular matrix (ECM). Understanding ECM's role EMT can uncover new therapeutic targets, yet replicating these interactions vitro remains challenging. It shown that hybrid hydrogels of alginate (ALG) and cell‐derived decellularized ECM (dECM), with independently tunable composition stiffness, are useful 3D‐models explore impact breast on EMT. Soft RGD‐ALG (200 Pa), used as neutral bulk material, supported mammary epithelial cells morphogenesis without spontaneous EMT, allowing define gene, protein, biochemical profiles at different TGFβ1‐induced states. To mimic composition, dECM from TGFβ1‐activated fibroblasts (adECM) generated, which shows upregulation tumor‐associated proteins compared ndECM normal fibroblasts. Using adECM‐ALG hydrogels, it presence adECM induces partial cells, amplifes TGF‐β1 effects ALG ndECM‐ALG. Increasing hydrogel stiffness tumor‐like levels (2.5 kPa) have a synergistic effect, promoting more evident These findings shed light complex interplay between underscoring utility dECM‐ALG valuable platform cancer research.

Language: Английский

Citations

0
Research progress in application of alginate gel as tumor drug delivery carrier, for tumor localization and 3D tumor cell model DOI Creative Commons

Lili Huang,

Yicong Lei,

Yu‐Cheng Chen

et al.

Journal of Holistic Integrative Pharmacy, Journal Year: 2024, Volume and Issue: 5(3), P. 174 - 184

Published: Sept. 1, 2024

Language: Английский

Citations

0
Research progress on cancer-associated fibroblasts in osteosarcoma DOI

Liwen Feng,

Yuting Chen,

W Jin

et al.

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 0(0), P. 1 - 10

Published: Jan. 1, 2024

Osteosarcoma (OS) is a prevalent primary bone malignancy with limited treatment options. Therefore, it imperative to investigate and understand the mechanisms underlying OS pathogenesis. Cancer-associated fibroblasts (CAFs) are markedly abundant in tumor stromal cells essentially involved modulation of occurrence development. In recent years, CAFs have become hotspot as researchers aim elucidate CAF that regulate progression. However, most studies on few common cancers, their association remains elusive. This review describes role current knowledge OS, focusing potential cellular origin, classification, diverse functionality. It was found influenced cell signaling, proliferation, invasion, metastasis, epithelial-mesenchymal transition, stemness maintenance, angiogenesis, ability modify immune system components. Furthermore, findings other cancers indicated effective therapeutic strategies included manipulation activation, targeting CAF-derived components, depletion by biomarkers. provides new insights theoretical basis for research.

Language: Английский

Citations

0