State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches DOI Creative Commons
Hossein Baniasadi

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103527 - 103527

Published: April 1, 2025

Language: Английский

Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin DOI Creative Commons

Monica-Cornelia Sardaru,

Irina Roșca, Simona Morariu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 35 - 35

Published: Jan. 4, 2025

In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating β-cyclodextrin (β-CD) boronic acid linkers into matrix to enhance antibacterial activity against Staphylococcus aureus (S. aureus). We systematically investigated how varying the number free moieties (ranging from two six), along with guanosine β-CD content, influences both structural integrity antimicrobial efficacy these materials. Comprehensive characterization using FTIR, circular dichroism, X-ray diffraction, SEM, AFM, rheological measurements confirmed successful synthesis revealed that higher content correlated stronger, more organized network. The most effective hydrogel displayed an inhibition zone 25 mm in disk diffusion assays, was further explored as drug delivery platform, aim exploit capacity cavity incorporate hydrophobic drugs. Norfloxacin (Nfx), poorly water-soluble antibiotic, successfully encapsulated within through inclusion complex formation β-CD, improving its solubility enabling sustained, targeted release. Nfx-loaded expanded 49 completely eradicated S. cells 24 h, outperforming unloaded Nfx. These results highlight synergistic effect controlled release, underlining potential versatile platforms for localized therapy, such wound dressings or implant coatings. Nevertheless, vivo studies long-term stability assessments are needed fully establish clinical relevance, safety, scalability before systems can be translated routine healthcare applications.

Language: Английский

Citations

0
Chitosan/alginate polyelectrolyte complex hydrogels by additive manufacturing for in vitro 3D ovarian Cancer modeling DOI
Simona Braccini, Gianni Pecorini,

Simone Biagini

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139795 - 139795

Published: Jan. 1, 2025

Language: Английский

Citations

0
Silk Protein-Based Triboelectric Nanogenerators for Energy Harvesting and Self-Powered Sensing DOI
Bo Shang, Chenyu Wang, Xiaoxue Wang

et al.

Sensors and Actuators A Physical, Journal Year: 2025, Volume and Issue: unknown, P. 116449 - 116449

Published: March 1, 2025

Language: Английский

Citations

0
Surprising Multiple Enhancement Effects of Carboxymethyl Chitosan-Co in Ammonium Perchlorate-Based Propellant DOI
Haozhe Li,

Xiandie Zhang,

Heng Xu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches DOI Creative Commons
Hossein Baniasadi

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103527 - 103527

Published: April 1, 2025

Language: Английский

Citations

0