Taguchi method optimisation for synthesising a novel Fe 3 O 4 @Sodium alginate-g-copolymer for enhanced methylene blue adsorption: optimisation, kinetics, and isotherm analyses DOI
Abbas A. Noor,

Nadher D. Radia

International Journal of Environmental & Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Dec. 11, 2024

This research paper includes a novel hydrogel as an adsorbent prepared via free radical polymerisation of sodium alginate-grafting-poly (N-isopropylacrylamide-co-hydroxy ethyl acrylamide-co-2-Acrylamido-2-methylpropane sulphonic acid) (HGs). Employing the Taguchi method, optimal concentrations monomers, alginate, initiator, and crosslinking agent were determined to achieve maximum swelling ratio for incorporation Fe2+ Fe3+ ions produce Fe3O4/HGS magnetic nanocomposites (MGHs) shown in Scheme 1. HGS MGHs characterised using various techniques, including infrared absorption spectrum (FTIR), field emission scanning electron microscope (FESEM), atomic force (AFM), transmission (TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET), Vibrating‑Sample Magnetometer (VSM). The study compared behaviours at different pH values both adsorbents. point zero charge PZC was studied understand adsorption behaviour, which equal 5.44 adsorbent. Adsorption kinetics exhibited pseudo-second-order behaviour after determining adsorbent's effective weight, is 0.002 g, equilibrium time, 60 min. isotherm showed good agreement with Langmuir Dubinin–Radushkevich models. Thermodynamic parameters calculated temperatures (5–35 °C), indicating physisorption. While removal percent Mb dye 95% Qe = 474.7 mg/g, conditions Response Surface Methodology (RSM) analysed through Analysis Variance (ANOVA). Results demonstrated that increases increasing temperature, confirming endothermic nature process. also investigated Reusability, high efficiency five cycles.

Language: Английский

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years DOI Creative Commons
Magdalena Stevanović, Nenad Filipović

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 670 - 670

Published: May 16, 2024

In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These offer promising strategies for targeted and controlled drug while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, healthcare landscape is constantly evolving, necessitating continual development innovative therapeutic approaches (DDSs). DDSs play a pivotal role enhancing treatment efficacy, minimizing adverse effects, optimizing patient compliance. Among these, nanotechnology-driven garnered due to their unique properties, such as improved solubility, release, delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., versatile platforms tissue engineering applications. Additionally, hold immense promise, leveraging natural or synthetic biopolymers encapsulate drugs enable release. numerous advantages, biocompatibility, biodegradability, low immunogenicity. The utilization polysaccharides, polynucleotides, proteins, polyesters biopolymer matrices further enhances versatility applicability DDSs. Moreover, substances emerged key players combating diseases, offering protection against cellular damage chronic illnesses. nanoformulations represents burgeoning research area, substantial increase publications years. This review provides comprehensive overview developments within this area over past five It discusses various materials, fabrication techniques, stabilizers, factors influencing degradation, it highlights emerging trends, challenges, prospects rapidly evolving field.

Language: Английский

Citations

13
Construction of Fu brick tea polysaccharide-cold plasma modified alginate microgels for probiotic delivery: Enhancing viability and colonization DOI
Rui Sun, Ying Wang,

Zhongyi Lv

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131899 - 131899

Published: April 25, 2024

Language: Английский

Citations

9
Understanding the journey of biopolymeric nanoformulations for oral drug delivery: Conventional to advanced treatment approaches DOI
Ameya Sharma,

Nitin Jangra,

Divya Dheer

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113338 - 113338

Published: July 26, 2024

Language: Английский

Citations

7
Optimization of Pb2+ adsorption onto Fe3O4/sodium alginate-grafted magnetic hydrogel using RSM: synthesis optimization via taguchi method DOI
Abbas A. Noor,

Nadher D. Radia

Journal of Porous Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Language: Английский

Citations

0
Berberine-loaded iron oxide nanoparticles alleviate cuprizone-induced astrocytic reactivity in a rat model of multiple sclerosis DOI Creative Commons
Ghadha Ibrahim Fouad, Mostafa Mabrouk, Sara A. M. El‐Sayed

et al.

BioMetals, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract Berberine (BBN) is a naturally occurring alkaloid as secondary metabolite in many plants and exhibits several benefits including neuroprotective activities. However, data on the neuromodulating potential of nanoformulated BBN are still lacking. In present study, loaded within iron oxide nanoparticles (BBN-IONP) were prepared characterized by transmission electron microscopy FTIR, X-ray photoelectron spectroscopy particle-size distribution, zeta potential, HPLC. The remyelinating BBN-IONP relative to free was evaluated against cuprizone (CPZ)-induced neurotoxicity (rats administered 0.2% CPZ powder (w/w) for five weeks). rats treated with either or IONP-BBN (50 mg/kg/day, orally) 14 days. Cognitive function estimated using Y-maze. Biochemically, total antioxidant capacity lipid peroxides reduced glutathione brain tissue, well as, serum interferon-gamma levels estimated. Moreover, genetic expression contents myelin basic protein Matrix metallopeptidase-9 Tumor necrosis factor-α (TNF-α), S100β measured. histopathological patterns immunohistochemical assessment Glial Fibrillary Acidic Protein both cerebral cortex hippocampus CA1 regions investigated. CPZ-rats demonstrated memory restoring, anti-oxidative, anti-inflammatory, anti-astrocytic, Comparing revealed that latter altered activities BBN, showing superior BBN. conclusion, forms possess potential. use IONPs delivery safety these nano-based need further investigation.

Language: Английский

Citations

2
Taguchi method optimisation for synthesising a novel Fe 3 O 4 @Sodium alginate-g-copolymer for enhanced methylene blue adsorption: optimisation, kinetics, and isotherm analyses DOI
Abbas A. Noor,

Nadher D. Radia

International Journal of Environmental & Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Dec. 11, 2024

This research paper includes a novel hydrogel as an adsorbent prepared via free radical polymerisation of sodium alginate-grafting-poly (N-isopropylacrylamide-co-hydroxy ethyl acrylamide-co-2-Acrylamido-2-methylpropane sulphonic acid) (HGs). Employing the Taguchi method, optimal concentrations monomers, alginate, initiator, and crosslinking agent were determined to achieve maximum swelling ratio for incorporation Fe2+ Fe3+ ions produce Fe3O4/HGS magnetic nanocomposites (MGHs) shown in Scheme 1. HGS MGHs characterised using various techniques, including infrared absorption spectrum (FTIR), field emission scanning electron microscope (FESEM), atomic force (AFM), transmission (TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET), Vibrating‑Sample Magnetometer (VSM). The study compared behaviours at different pH values both adsorbents. point zero charge PZC was studied understand adsorption behaviour, which equal 5.44 adsorbent. Adsorption kinetics exhibited pseudo-second-order behaviour after determining adsorbent's effective weight, is 0.002 g, equilibrium time, 60 min. isotherm showed good agreement with Langmuir Dubinin–Radushkevich models. Thermodynamic parameters calculated temperatures (5–35 °C), indicating physisorption. While removal percent Mb dye 95% Qe = 474.7 mg/g, conditions Response Surface Methodology (RSM) analysed through Analysis Variance (ANOVA). Results demonstrated that increases increasing temperature, confirming endothermic nature process. also investigated Reusability, high efficiency five cycles.

Language: Английский

Citations

0