Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 31, 2024

Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering anticancer drugs due to their distinctive characteristics. They have the potential enclose hydrophobic molecules, thereby enhancing solubilities, permeabilities, and bioavailabilities; without use of surfactant, i.e., through surfactant-free solubilization. This allows higher drug concentrations at tumor sites, prevents excessive toxicity imparted by surfactants, could circumvent resistance. Moreover, biomedical engineers formulation scientists can also fabricate chitosan NPs slowly release agents. keeps site longer, makes therapy more effective, lowers frequency dosing. Notably, some types cancer cells (fallopian tube, epithelial tumors ovary, primary peritoneum; lung, kidney, ependymal brain, uterus, breast, colon, malignant pleural mesothelioma) overexpression folate receptors (FRs) on outer surface, which lets folate-drug conjugate–incorporated target kill them effectively. Strikingly, there is evidence suggesting that excessively produced FR&αgr (isoforms FR) stays consistent throughout treatment in ovarian endometrial cancer, indicating resistance conventional treatment; this regard, folate-anchored overcome it improve therapeutic outcomes. Interestingly, overly expressed FRs present only certain types, a biomarker predicting effectiveness FR-targeted therapy. On other hand, folate-modified enhance oral absorption medicines, especially drugs, pave way effective long-term low-dose metronomic scheduling poorly soluble permeable drugs. In review, we talked briefly about techniques used create, characterize, tailor chitosan-based NPs; delved deeper into applications folate-engineered treating various types. Schematic illustration ligand-drug incorporated its advantage cancer. Figure created with BioRender.Com.

Language: Английский

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A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141394 - 141394

Published: Feb. 1, 2025

Language: Английский

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Exploring Protein-Based Carriers in Drug Delivery: A Review

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1172 - 1172

Published: Sept. 5, 2024

Drug delivery systems (DDSs) represent an emerging focus for many researchers and they are becoming progressively crucial in the development of new treatments. Great attention is given to all challenges that a drug has overcome during its journey across barriers tissues pharmacokinetics modulations needed order reach targeting sites. The goal these pathways drugs controlled way, optimizing their bioavailability minimizing side effects. Recent innovations DDSs include various nanotechnology-based approaches, such as nanoparticles, nanofibers micelles, which provide effective targeted sustained release therapeutics. In this context, protein-based gaining significant pharmaceutical field due potential revolutionize efficient delivery. As natural biomolecules, proteins offer distinct advantages, including safety, biocompatibility biodegradability, making them fascinating alternative synthetic polymers. Moreover, carriers, those derived from gelatin, albumin, collagen, gliadin silk proteins, demonstrate exceptional stability under physiological conditions, allow release, enhancing therapeutic efficacy. This review provides comprehensive overview current trends, challenges, future perspectives delivery, focusing on types adopted techniques being developed enhance functionality terms affinity capabilities, underscoring significantly impact modern

Language: Английский

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Exosomes: A Promising Drug Delivery Tool in Hepatic Drug Delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106761 - 106761

Published: March 1, 2025

Language: Английский

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Revealing Three-Dimensional Printing Technology Advances for Oral Drug Delivery: Application to Central-Nervous-System-Related Diseases

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 445 - 445

Published: March 31, 2025

Background/Objectives. Central nervous system (CNS)-related diseases such as Alzheimer’s and Parkinson’s, Attention Deficit Hyperactive Disorder (ADHD), stroke, epilepsy, migraines are leading causes of morbidity disability worldwide. New solutions for drug delivery increasingly needed. In this context, three-dimensional (3D) printing technology has introduced innovative alternatives to produce more efficient medicines with diverse features, patterns, consistencies, particularly oral medications. Even though research in area is growing rapidly, no study thoroughly analyzed 3D progress the CNS. To fill gap pursues determine a technological landscape field. Methods. For aim, Competitive Technology Intelligence (CTI) methodology was applied, examining 747 publications from 1 January 2019 20 May 2024 published Scopus database. Results. The main advances identified comprise six categories: techniques, characteristics applications, materials, design factors, user acceptance, quality processes. FDM technique pharmaceutical use. applications include pills, polypills, caplets, gel caps, multitablets, orodispersible films, tablets, featuring external patterns internal structures one or active substances. Insights show that most utilized materials thermoplastic polymers like PLA, PVA, PCL, ABS, HIPS. A novel factor involves release using compartments varying thicknesses volumes core. Additionally, specialized software have enabled creation highly complex designs. acceptance category, drugs dosages tailored specific needs preferences neurological patients. Finally, aspect, precision Active Pharmaceutical Ingredient (API) dosage controlled-release mechanisms critical, given narrow margin between therapeutic doses toxicity CNS diseases. Conclusions. Revealing these advancements allows researchers, academics, decision-makers identify opportunities allocate resources efficiently, promising enhanced medicaments health well-being individuals suffering disorders.

Language: Английский

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Natural polysaccharide-based nanodrug delivery systems for targeted treatment of rheumatoid arthritis: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143408 - 143408

Published: April 1, 2025

Language: Английский

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Precise tailoring of thermoresponsive characteristics: Revealing ATRP opportunities for controlled poly(ethylene glycol)-based monomers composition in cyclodextrin-containing polymers

Polymer, Journal Year: 2024, Volume and Issue: unknown, P. 127645 - 127645

Published: Sept. 1, 2024

Language: Английский

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