Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress DOI Creative Commons
Shahab Ghaderi, Masome Rashno, Alireza Sarkaki

et al.

Brain Research Bulletin, Journal Year: 2023, Volume and Issue: 206, P. 110852 - 110852

Published: Dec. 21, 2023

Lead (Pb) is a well-known toxic pollutant that has negative effects on behavioral functions. Sesamin, phytonutrient of the lignan class, shown neuroprotective in various neurological disorder models. The present study was undertaken to evaluate putative protective sesamin against Pb-induced deficits and identify role oxidative stress male rats. rats were exposed 500 ppm Pb acetate their drinking water simultaneously treated orally with at dose 30 mg/kg/day for eight consecutive weeks. Standard paradigms used assess functions animals during eighth week study. Subsequently, factors evaluated both cerebral cortex hippocampal regions results this showed exposure triggered anxiety-/depression-like behaviors impaired object recognition memory, but locomotor activity indistinguishable from normal control These deficiencies associated suppressed enzymatic non-enzymatic antioxidant levels, enhanced lipid peroxidation investigated brain regions. Notably, correlations detected between generation Pb-exposed Interestingly, treatment mitigated anxio-depressive-like behaviors, ameliorated memory impairment, modulated oxidative-antioxidative status Pb. suggest anti-oxidative properties may be one underlying mechanisms behind its beneficial effect ameliorating exposure.

Language: Английский

Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment DOI
Lokesh Murumulla,

Lakshmi Jaya Madhuri Bandaru,

Suresh Challa

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(4), P. 1411 - 1427

Published: July 18, 2023

Language: Английский

Citations

24
Dynamic Proteome and Phosphoproteome Profiling Reveals Regulatory Mechanisms in LPS-Stimulated Macrophage Inflammatory Responses DOI
Chenyang Huang, Yuying Liang,

Aolin Jiang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151341 - 151341

Published: Jan. 1, 2025

Language: Английский

Citations

2
From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury DOI Creative Commons
Yimin Yuan, Hong Liu,

Ziwei Dai

et al.

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract In the mammalian central nervous system (CNS), astrocytes are ubiquitous glial cells that have complex morphological and molecular characteristics. These fascinating play essential neurosupportive homeostatic roles in healthy CNS undergo morphological, molecular, functional changes to adopt so-called ‘reactive’ states response injury or disease. recent years, interest astrocyte research has increased dramatically some new biological features of physiological pathological conditions been discovered thanks technological advances. Here, we will review discuss well-established emerging astroglial biology functions, with emphasis on their potential as therapeutic targets for injury, including traumatic ischemic injury. This article highlight importance neuropathological process repair

Language: Английский

Citations

7
The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis DOI Creative Commons

Kangqin Yang,

Yang Liu, Min Zhang

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(2), P. 158 - 158

Published: Feb. 4, 2024

Astrocytes displaying reactive phenotypes are characterized by their ability to remodel morphologically, molecularly, and functionally in response pathological stimuli. This process results the loss of typical astrocyte functions acquisition neurotoxic or neuroprotective roles. A growing body research indicates that these astrocytes play a pivotal role pathogenesis amyotrophic lateral sclerosis (ALS), involving calcium homeostasis imbalance, mitochondrial dysfunction, abnormal lipid lactate metabolism, glutamate excitotoxicity, etc. review summarizes characteristics astrocytes, ALS, recent advancements astrocyte-targeting strategies.

Language: Английский

Citations

6
Environmentally Relevant Lead Exposure Alters Cell Morphology and Expression of Neural Hallmarks During SH-SY5Y Neuronal Differentiation DOI Creative Commons
Rachel K. Morgan, Anagha Tapaswi, Katelyn M. Polemi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Lead (Pb) continues to be a public health burden, in the US and around world, yet effects of historical current exposure levels on neurogenesis are not fully understood. Here we examine range environmentally relevant Pb concentrations (0.16μM, 1.26μM, 10μM Pb) relative control neural differentiation SH-SY5Y cell model. began Day 5 continued throughout at 18. We assessed morphological measures related several time points during this process, including expression proteins key (β-tubulin III GAP43), number size, as well development neurites. The bulk detectable changes occurred with exposure, most notably that β-tubulin GAP43 expression. Effects 0.16μM 1.26μM conditions increased progressed, significant reductions nuclear size length projections by Best benchmark concentration (BMC) analysis revealed many these metrics susceptible or below historically levels. This work highlights disruption neurite formation protein potential new mechanisms which impacts morphology perturb cognitive life course.

Language: Английский

Citations

0
Black soybean peptide mediates the AMPK/SIRT1/NF-κB signaling pathway to alleviate Alzheimer's-related neuroinflammation in lead-exposed HT22 cells DOI

Huijie Yang,

Fangyu Wang, Peijun Zhao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138404 - 138404

Published: Dec. 4, 2024

Language: Английский

Citations

2
Mitigating lead acetate-induced histopathologic and physiologic disorders in rats receiving vitamin C and glutathione supplement DOI Creative Commons
Mohamed Gaber Shalan

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41256 - e41256

Published: Dec. 14, 2024

Language: Английский

Citations

2
Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress DOI Creative Commons
Shahab Ghaderi, Masome Rashno, Alireza Sarkaki

et al.

Brain Research Bulletin, Journal Year: 2023, Volume and Issue: 206, P. 110852 - 110852

Published: Dec. 21, 2023

Lead (Pb) is a well-known toxic pollutant that has negative effects on behavioral functions. Sesamin, phytonutrient of the lignan class, shown neuroprotective in various neurological disorder models. The present study was undertaken to evaluate putative protective sesamin against Pb-induced deficits and identify role oxidative stress male rats. rats were exposed 500 ppm Pb acetate their drinking water simultaneously treated orally with at dose 30 mg/kg/day for eight consecutive weeks. Standard paradigms used assess functions animals during eighth week study. Subsequently, factors evaluated both cerebral cortex hippocampal regions results this showed exposure triggered anxiety-/depression-like behaviors impaired object recognition memory, but locomotor activity indistinguishable from normal control These deficiencies associated suppressed enzymatic non-enzymatic antioxidant levels, enhanced lipid peroxidation investigated brain regions. Notably, correlations detected between generation Pb-exposed Interestingly, treatment mitigated anxio-depressive-like behaviors, ameliorated memory impairment, modulated oxidative-antioxidative status Pb. suggest anti-oxidative properties may be one underlying mechanisms behind its beneficial effect ameliorating exposure.

Language: Английский

Citations

5