Cited by Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails

Unraveling lipopolysaccharide-induced behavioral and molecular effects in Lymnaea stagnalis, an emerging model organism for translational neuroscience DOI

Veronica Rivi, Giovanna Rigillo,

Silvia Alboni

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114418 - 114418

Published: March 15, 2025

Language: Английский

Citations

Chronic tributyltin exposure induces metabolic disruption in an invertebrate model animal, Lymnaea stagnalis DOI

I Fodor, J. Schmidt, Réka Svigruha

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 107404 - 107404

Published: May 1, 2025

Language: Английский

Citations

Different stressors uniquely affect the expression of endocannabinoid‐metabolizing enzymes in the central ring ganglia of Lymnaea stagnalis DOI

Veronica Rivi, Giovanna Rigillo, Anuradha Batabyal

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

The endocannabinoid system (ECS) plays an important role in neuroprotection, neuroplasticity, energy balance, modulation of stress, and inflammatory responses, acting as a critical link between the brain body's peripheral regions, while also offering promising potential for novel therapeutic strategies. Unfortunately, humans, pharmacological inhibitors different ECS enzymes have led to mixed results both preclinical clinical studies. As has been highly conserved throughout eukaryotic lineage, use invertebrate model organisms like pond snail Lymnaea stagnalis may provide flexible tool unravel unexplored functions at cellular, synaptic, behavioral levels. In this study, starting from available genome transcriptome L. stagnalis, we first identified putative transcripts all containing open reading frame. Each predicted protein possessed high degree sequence conservation known orthologues other vertebrate organisms. Sequences were confirmed by qualitative PCR sequencing. Then, investigated transcriptional effects induced stress conditions (i.e., bacterial LPS injection, predator scent, food deprivation, acute heat shock) on expression levels Lymnaea's central ring ganglia. Our suggest that rodents, is involved mediating anxiety-like promoting responding stressors. To our knowledge, study offers most comprehensive analysis so far organism.

Language: Английский

Citations

Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis DOI

Veronica Rivi, Giuseppe Caruso, Filippo Caraci

et al.

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(8)

Published: July 30, 2024

Carnosine is a naturally occurring endogenous dipeptide with well-recognized anti-inflammatory, antioxidant, and neuroprotective effects at the central nervous system level. To date, very few studies have been focused on ability of carnosine to rescue and/or enhance memory. Here, we used well-known invertebrate model system, pond snail Lymnaea stagnalis, well-studied associative learning procedure, operant conditioning aerial respiration, investigate long-term memory (LTM) formation reverse obstruction caused by an immune challenge (i.e., lipopolysaccharide [LPS] injection). Exposing snails 1 mM for h before training in addition enhancing resulted significant upregulation expression levels key neuroplasticity genes glutamate ionotropic receptor N-methyl-d-aspartate [NMDA]-type subunit 1-LymGRIN1, transcription factor cAMP-response element-binding protein 1-LymCREB1) snails' ring ganglia. Moreover, pre-exposure LPS injection reversed deficit brought about inflammation, preventing targets stress response Toll-like 4-LymTLR4, molluscan defense molecule-LymMDM, heat shock 70-LymHSP70). Our data are thus consistent hypothesis that can positive benefits cognitive be able aversive states induced neuroinflammation.

Language: Английский

Citations

How to reduce fear in a snail: Take an aspirin, call me in the morning DOI

Jasper Hollings,

Diana Kagan, Anuradha Batabyal

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 284, P. 109978 - 109978

Published: July 31, 2024

Aspirin (Acetylsalicylic acid, ASA), one of the widely used non-steroid anti-inflammatory drugs can easily end up in sewage effluents and thus it becomes necessary to investigate effects aspirin on behaviour aquatic organisms. Previous studies mammals have shown ASA alter fear anxiety-like behaviours. In great pond snail Lymnaea stagnalis, has been block a 'sickness state' induced by lipopolysaccharide injection which upregulates immune stress-related genes altering behavioural responses. Lymnaea, eliciting physiological stress may enhance memory formation or its retrieval depending stimulus type intensity. Here we examine whether will two forms associative-learning crayfish predator-experienced when exposure accompanies predator-cue-induced during learning procedure. The trainings procedures are: 1) operant conditioning aerial respiration; 2) higher form learning, called configural here is dependent evoking response. We show that alone does not homeostatic respiration, feeding long-term (LTM) operantly conditioned respiration. However, blocked enhancement LTM normally elicited training snails predator cue. also makes use response Thus, alters how responds cognitively detection.

Language: Английский

Citations

Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails DOI

Veronica Rivi, Anuradha Batabyal, Cristina Benatti

et al.

Water Biology and Security, Journal Year: 2024, Volume and Issue: unknown, P. 100315 - 100315

Published: Oct. 1, 2024

Language: Английский

Citations