Hemoglobin,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 6
Published: Dec. 10, 2024
Hemoglobin
disorders
are
highly
prevalent
inherited
hematological
defects
in
Southern
China.
The
identification
of
novel
variants
globin
genes
and
accurate
assessment
parameters
play
a
crucial
role
precise
genetic
counseling
clinical
practice.
Peripheral
blood
samples
were
collected
for
analysis,
including
red
cell
hemoglobin
assessment,
while
serum
ferritin
levels
measured
to
detect
iron
depletion.
Thalassemia
carrier
was
conducted
four
subjects
admitted
Jiangxi
Maternal
Child
Health
Hospital
using
next-generation
sequencing
Gap-PCR
due
the
high
prevalence
thalassemia
Province.
identified
rare
or
small
nucleotide
subsequently
validated
through
Sanger
sequencing.
A
total
incidentally
unrelated
subjects,
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(16), P. 18458 - 18468
Published: April 15, 2024
Imbalances
in
hemoglobin
(Hb)
levels
can
lead
to
conditions
such
as
anemia
or
polycythemia,
emphasizing
the
importance
of
precise
Hb
extraction
from
blood.
To
address
this,
a
novel
synthetic
imprinted
polymer
was
meticulously
developed
for
capturing
and
separating
Hb.
Poly(acrylamide-vinylimidazole)
nanopolymer
(poly(AAm-VIM))
synthesized
using
acrylamide
vinyl
imidazole
functional
monomers
through
surfactant-free
emulsion
polymerization.
Characterization
FTIR,
particle
size,
zeta
potential,
SEM
ensured
polymer's
structure.
The
Hb-imprinted
(Hb-poly(AAm-VIM))
demonstrated
notable
specificity,
with
calculated
Hb-specific
adsorption
value
(Qmax)
3.7377
mg/g
medium
containing
2.5
mg/mL
molecularly
(MIP)
exhibited
approximately
5
times
higher
than
nonimprinted
(NIP).
Under
same
conditions,
displayed
2.39
2.17
greater
selectivity
over
competing
proteins
bovine
serum
albumin
(BSA)
lysozyme
(Lys),
respectively.
Also,
SDS-PAGE
analysis
results
confirmed
purification
by
nanopolymer.
These
underscore
heightened
specificity
efficacy
selectively
targeting
atoms
among
other
proteins.
Incorporating
polymers
is
justified
their
affinity,
cost-effectiveness,
facile
production.
This
research
contributes
valuable
insights
into
optimizing
efficient
extraction,
potential
medical
diagnostics
treatment
applications.
Electrophoresis,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
ABSTRACT
Hemoglobinopathies,
hereditary
disorders
affecting
the
structure
or
production
of
hemoglobin,
were
detected
by
routine
HbA
1c
measurements
capillary
electrophoresis
(CE)
at
University
Hospital
Motol,
Prague.
The
potential
ultraviolet–visible
(UV–Vis)
and
Fourier‐transform
infrared
(FTIR)
spectroscopy
for
detection
characterization
hemoglobinopathies
was
investigated.
FTIR
spectra
recorded
with
a
very
high
resolution
(0.5
cm
−1
)
128
scans.
broad
amide
I
peak,
located
1700–1600
,
can
be
formed
superimposition
conformational
structures
hemoglobin.
These
secondary
protein
subjected
to
mathematical
analysis.
application
band
narrowing
techniques,
followed
curve
fitting
integration
processes,
provided
basis
quantitative
estimation
structure.
As
result,
unambiguous
differences
in
UV–Vis
among
patients
presumably
normal
an
HbC
hemoglobin
S/hemoglobin
G
(HbS/HbG)‐Philadelphia
variant
could
not
demonstrated.
However,
indicated
slight
α‐helix,
β‐turns,
β‐sheet,
random
coil
these
mutations.
In
spectral
wavenumber
range
950–850
there
some
obvious
specific
wavenumbers
between
those
variant.
Further
investigations
are
needed
sufficient
number
variants
elucidate
potency
hemoglobinopathies.
World Journal of Clinical Cases,
Journal Year:
2025,
Volume and Issue:
13(15)
Published: Jan. 21, 2025
The
compelling
case
report
by
Xie
et
al
,
published
in
a
renowned
medical
journal,
is
an
excellent
example
of
meticulous
clinical
evaluation,
comprehensive
laboratory
testing,
advanced
imaging,
and
genetic
analysis.
authors
identified
novel
compound
heterozygous
mutations
the
hemojuvelin
gene
patient
diagnosed
with
juvenile
hemochromatosis.
They
suggested
that
long-term,
strategic
phlebotomy
might
offer
therapeutic
strategy
for
severe
hemochromatosis,
challenging
traditional
treatment
paradigms.
Annals of Hematology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Hemoglobinopathies
are
among
the
most
common
inherited
diseases
and
they
believed
to
be
one
of
major
etiologic
factors
contributing
anemia.
Thalassemia
is
characterized
by
an
altered
hemoglobin
(Hb)
chain
synthesis
may
appear
as
alpha-(α-)thalassemia
and/or
beta-(β-)thalassemia.
The
clinical
manifestations
thalassemia
range
from
asymptomatic
severe,
with
potential
ultimately
result
in
death.
search
for
underlying
cause
was
prompted
discovery
patient
Thai
origin
microcytic
anemia
no
iron
deficiency
during
a
routine
hematological
examination.
Genetic
sequencing
results
revealed
Hb
Paksé,
α2
CD
142
[A
>
T]
(HBA2:c.429
A
T)
HbE
β2
26
[G
A]
(HBB:
c.79
G
A).
It
essential
that
identification
knowledge
mutations
facilitate
recognition,
genetic
testing,
counseling
patients
thalassemia.
combination
two
variants,
α-globin
gene
Paksé
β-globin
E,
single
individual
occasionally
described
East
Asia.
first
appearance
combined
heterozygosity
E
Europe
provides
evidence
this
migration-caused
occurrence.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(3), P. 197 - 197
Published: March 20, 2025
This
article
explores
the
development
and
application
of
innovative
piezoelectric
sensors
in
point-of-care
diagnostics.
It
highlights
significance
bedside
tests,
such
as
lateral
flow
electrochemical
providing
rapid
accurate
results
directly
at
patient’s
location.
paper
delves
into
principles
assays,
emphasizing
their
ability
to
detect
disease-related
biomarkers
through
mechanical
stress-induced
electrical
signals.
Various
applications
chemosensors
biosensors
are
discussed,
including
use
detection
cancer
biomarkers,
pathogens,
other
health-related
analytes.
also
addresses
integration
materials
with
advanced
sensing
technologies
improve
diagnostic
accuracy
efficiency,
offering
a
comprehensive
overview
current
advances
future
directions
medical
Indonesian Journal of Computer Science,
Journal Year:
2024,
Volume and Issue:
13(3)
Published: June 15, 2024
This
article
presents
a
comprehensive
systematic
review
of
recent
advancements
in
machine
learning
(ML)
applications
for
diagnosing
Thalassemia,
genetic
hematologic
disorder.
Focusing
on
studies
from
the
last
five
years,
this
highlighted
significant
technological
ML,
including
use
predictive
modeling,
image
analysis,
and
deep
algorithms,
which
have
considerably
improved
accuracy
efficiency
Thalassemia
diagnosis.
The
evaluates
application
various
ML
models
analyzing
extensive
biomedical
data,
significantly
enhances
patient
management
treatment
outcomes.
Key
challenges
such
as
data
diversity,
model
transparency,
need
robust
training
datasets
are
discussed,
along
with
integration
into
existing
clinical
workflows.
potential
transformative
impact
hematology
is
underscored,
critically
evaluating
its
effectiveness
ongoing
developments
field.
aims
to
provide
insights
current
research
trends
future
directions
diagnosis
other
similar
hematological
disorders.
Analytical Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
study
proposes
a
ResNet34
DL
model
for
automated
SCD
diagnosis
using
mIEF
Hb
S,
achieving
90.1%
accuracy
in
classifying
variants.
model's
precision
suggests
it
could
reduce
costs
and
the
reliance
on
need
expert
diagnosis.
