Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 519 - 519

Published: July 12, 2024

Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.

Language: Английский

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Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 650 - 650

Published: Jan. 14, 2025

Sphingolipidomic mass spectrometry has provided valuable information-and surprises-about sphingolipid structures, metabolism, and functions in normal biological processes disease. Nonetheless, many noteworthy compounds are not routinely determined, such as the following: most of sphingoid bases that mammals biosynthesize de novo other than sphingosine (and sometimes sphinganine) or acquire from exogenous sources; infrequently considered metabolites bases, N-(methyl)n-derivatives; "ceramides" common N-acylsphingosines; complex sphingolipids sphingomyelins simple glycosphingolipids, including glucosyl- galactosylceramides, which usually reported "monohexosylceramides". These subspecies discussed, well some circumstances when they likely to be seen (or present missed) due experimental conditions can influence uptake diet microbiome, artifacts produced during extraction analysis. If these factors kept mind design interpretation lipidomic studies, investigators surprised by how often appear thereby advance knowledge about them.

Language: Английский

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The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives

Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: 476(12), P. 1845 - 1861

Published: Oct. 9, 2024

Abstract Chronic kidney disease (CKD) is a multifactorial condition with diverse etiologies, such as diabetes mellitus, hypertension, and genetic disorders, often culminating in end-stage renal (ESRD). A hallmark of CKD progression fibrosis, characterized by the excessive accumulation extracellular matrix components, for which there currently no effective anti-fibrotic therapy. Recent literature highlights critical role sphingosine 1-phosphate (S1P) signaling pathogenesis fibrosis. This review provides an in-depth analysis latest findings on S1P metabolism fibrosis specific CKDs, including diabetic nephropathy (DN), lupus nephritis (LN), focal segmental glomerulosclerosis (FSGS), Fabry (FD), IgA (IgAN). Emerging studies underscore therapeutic potential modulating receptor modulators inhibitors, fingolimod (FTY720) more selective agents like ozanimod cenerimod. Additionally, current knowledge about effects established protective therapies glucocorticoids SGLT2 ACE inhibitors will be summarized. Furthermore, biomarker models, particularly nephropathy. Advanced technologies, spatial transcriptomics, are further refining our understanding S1P’s within compartments. Collectively, these insights emphasize need continued research into pathways promising targets treatment strategies.

Language: Английский

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How Protein Depletion Balances Thrombosis and Bleeding Risk in the Context of Platelet’s Activatory and Negative Signaling

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10000 - 10000

Published: Sept. 17, 2024

Platelets are small cell fragments that play a crucial role in hemostasis, requiring fast response times and fine signaling pathway regulation. For this regulation, platelets require balance between two types: the activatory negative pathways. Activatory mediators positive responses enhance stimuli initiated by receptor platelet membrane. Negative regulates controls downstream of same receptors to roll back or even avoid spontaneous thrombotic events. Several blood-related pathologies can be observed when these processes unregulated, such as massive bleeding inhibition events for inhibition. The study each protein metabolite isolation does not help understand how it contrasted; however, understanding active could develop effective therapies prevent disorders.

Language: Английский

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Moving metabolomics into the routine of clinical laboratories: A forward-thinking strategy

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120012 - 120012

Published: Oct. 1, 2024

Language: Английский

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