Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(8), P. 485 - 498

Published: Feb. 1, 2021

Language: Английский

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Mitochondrial metabolism and cancer

Cell Research, Journal Year: 2017, Volume and Issue: 28(3), P. 265 - 280

Published: Dec. 8, 2017

Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view instrumental development of powerful imaging tools that are still used clinics, it is now clear mitochondria play key role oncogenesis. Besides exerting central bioenergetic functions, provide indeed building blocks tumor anabolism, control redox calcium homeostasis, participate transcriptional regulation, govern cell death. Thus, constitute promising targets novel anticancer agents. However, tumors arise, progress, respond to therapy context an intimate crosstalk with host immune system, many immunological functions rely on intact mitochondrial metabolism. Here, we review cell-intrinsic cell-extrinsic mechanisms through which influence all steps oncogenesis, focus therapeutic potential targeting metabolism therapy.

Language: Английский

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NK cells for cancer immunotherapy

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(3), P. 200 - 218

Published: Jan. 6, 2020

Language: Английский

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The lung microenvironment: an important regulator of tumour growth and metastasis

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 19(1), P. 9 - 31

Published: Dec. 10, 2018

Language: Английский

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The updated landscape of tumor microenvironment and drug repurposing

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Aug. 25, 2020

Abstract Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram initiation, growth, invasion, metastasis, response to therapies. Cancer research treatment have switched from a cancer-centric model TME-centric one, considering the increasing significance of TME cancer biology. Nonetheless, clinical efficacy therapeutic strategies targeting TME, especially specific cells or pathways remains unsatisfactory. Classifying chemopathological characteristics crosstalk among one another greatly benefit further studies exploring effective treating methods. Herein, we present an updated image with emphasis on hypoxic niche, immune microenvironment, metabolism acidic innervated mechanical microenvironment. We then summarize conventional drugs including aspirin, celecoxib, β-adrenergic antagonist, metformin, statin new antitumor application. These are considered as viable candidates for combination therapy due their activity extensive use practice. also provide our outlook directions potential applications theory. This review depicts comprehensive vivid landscape biology treatment.

Language: Английский

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Natural killer cells and other innate lymphoid cells in cancer

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(11), P. 671 - 688

Published: Sept. 12, 2018

Language: Английский

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Nanomaterials for cancer therapy: current progress and perspectives

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: May 31, 2021

Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, electrical properties. used cancer therapy can be classified into several main categories. Targeting cells, tumor microenvironment, immune system, these nanomaterials have been modified for wide range therapies to overcome toxicity enhance drug capacity well bioavailability. Although number studies has increasing, approved nano-drugs not increased much over years. To better improve clinical translation, further research needed targeted delivery by nano-carriers reduce toxicity, permeability retention effects, minimize shielding effect protein corona. This review summarizes novel fabricated use, discusses current limitations obstacles that hinder translation from provides suggestions more efficient adoption therapy.

Language: Английский

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Rhabdomyosarcoma

Nature Reviews Disease Primers, Journal Year: 2019, Volume and Issue: 5(1)

Published: Jan. 7, 2019

Language: Английский

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NK cell-based cancer immunotherapy: from basic biology to clinical development

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: Jan. 6, 2021

Abstract Natural killer (NK) cell is a specialized immune effector type that plays critical role in activation against abnormal cells. Different from events required for T activation, NK governed by the interaction of receptors with target cells, independent antigen processing and presentation. Due to relatively unsophisticated cues has gained significant attention field cancer immunotherapy. Many efforts are emerging developing engineering cell-based In this review, we provide our current understandings biology, ongoing pre-clinical clinical development therapies discuss progress, challenges, future perspectives.

Language: Английский

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The hallmarks of successful anticancer immunotherapy

Science Translational Medicine, Journal Year: 2018, Volume and Issue: 10(459)

Published: Sept. 19, 2018

Various features of the tumor and immune system influence success immunotherapy.

Language: Английский

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